YME1L1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	33 studies	26% ± 9%	Explore
natural killer cell	29 studies	26% ± 8%	Explore
macrophage	27 studies	25% ± 7%	Explore
B cell	26 studies	25% ± 8%	Explore
fibroblast	26 studies	25% ± 9%	Explore
CD4-positive, alpha-beta T cell	24 studies	26% ± 9%	Explore
CD8-positive, alpha-beta T cell	23 studies	25% ± 6%	Explore
classical monocyte	20 studies	28% ± 10%	Explore
regulatory T cell	20 studies	27% ± 7%	Explore
T cell	19 studies	26% ± 8%	Explore
mast cell	18 studies	23% ± 7%	Explore
plasmacytoid dendritic cell	17 studies	30% ± 10%	Explore
smooth muscle cell	16 studies	21% ± 6%	Explore
naive B cell	16 studies	24% ± 7%	Explore
non-classical monocyte	16 studies	27% ± 11%	Explore
memory B cell	16 studies	24% ± 5%	Explore
monocyte	15 studies	23% ± 6%	Explore
conventional dendritic cell	15 studies	25% ± 13%	Explore
mature NK T cell	15 studies	26% ± 8%	Explore
gamma-delta T cell	14 studies	31% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	25% ± 9%	Explore
pericyte	13 studies	25% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	27% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	27% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	30% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	26% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	33% ± 10%	Explore
mucosal invariant T cell	11 studies	30% ± 9%	Explore
endothelial cell of lymphatic vessel	10 studies	23% ± 5%	Explore
ciliated cell	10 studies	29% ± 16%	Explore
oligodendrocyte precursor cell	10 studies	29% ± 13%	Explore
myeloid cell	10 studies	27% ± 14%	Explore
epithelial cell	10 studies	37% ± 23%	Explore
astrocyte	10 studies	30% ± 12%	Explore
connective tissue cell	9 studies	22% ± 6%	Explore
oligodendrocyte	9 studies	28% ± 9%	Explore
GABAergic neuron	8 studies	40% ± 20%	Explore
glutamatergic neuron	8 studies	41% ± 27%	Explore
myofibroblast cell	8 studies	24% ± 5%	Explore
basal cell	8 studies	31% ± 9%	Explore
plasma cell	7 studies	24% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	32% ± 8%	Explore
dendritic cell	7 studies	31% ± 18%	Explore
endothelial cell of vascular tree	7 studies	22% ± 5%	Explore
type I pneumocyte	6 studies	21% ± 4%	Explore
hematopoietic precursor cell	6 studies	27% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	23% ± 5%	Explore
leukocyte	6 studies	28% ± 7%	Explore
mononuclear phagocyte	6 studies	24% ± 8%	Explore
capillary endothelial cell	6 studies	20% ± 4%	Explore
abnormal cell	6 studies	26% ± 8%	Explore
interneuron	6 studies	39% ± 22%	Explore
microglial cell	6 studies	25% ± 6%	Explore
lymphocyte	6 studies	27% ± 13%	Explore
precursor B cell	6 studies	29% ± 5%	Explore
adipocyte	6 studies	23% ± 5%	Explore
vein endothelial cell	6 studies	23% ± 8%	Explore
T follicular helper cell	6 studies	29% ± 11%	Explore
innate lymphoid cell	6 studies	30% ± 9%	Explore
goblet cell	6 studies	30% ± 16%	Explore
plasmablast	5 studies	47% ± 19%	Explore
respiratory goblet cell	5 studies	22% ± 8%	Explore
secretory cell	5 studies	26% ± 5%	Explore
pro-B cell	5 studies	26% ± 4%	Explore
pancreatic A cell	4 studies	38% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	33% ± 13%	Explore
exhausted T cell	4 studies	25% ± 9%	Explore
glomerular endothelial cell	4 studies	34% ± 10%	Explore
neuron	4 studies	36% ± 9%	Explore
progenitor cell	4 studies	20% ± 1%	Explore
club cell	4 studies	25% ± 5%	Explore
immature B cell	4 studies	29% ± 3%	Explore
type II pneumocyte	4 studies	24% ± 8%	Explore
retinal pigment epithelial cell	4 studies	35% ± 15%	Explore
endothelial cell of artery	4 studies	22% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	35% ± 9%	Explore
hematopoietic stem cell	4 studies	20% ± 2%	Explore
alveolar macrophage	4 studies	22% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	24% ± 5%	Explore
ionocyte	3 studies	23% ± 4%	Explore
squamous epithelial cell	3 studies	40% ± 24%	Explore
type B pancreatic cell	3 studies	45% ± 21%	Explore
GABAergic interneuron	3 studies	21% ± 4%	Explore
glial cell	3 studies	22% ± 6%	Explore
retina horizontal cell	3 studies	18% ± 1%	Explore
retinal cone cell	3 studies	22% ± 5%	Explore
tissue-resident macrophage	3 studies	20% ± 4%	Explore
Mueller cell	3 studies	18% ± 2%	Explore
rod bipolar cell	3 studies	19% ± 2%	Explore
CD4-positive helper T cell	3 studies	31% ± 11%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	21% ± 4%	Explore
muscle cell	3 studies	32% ± 15%	Explore
pancreatic ductal cell	3 studies	50% ± 21%	Explore
neutrophil	3 studies	20% ± 1%	Explore
enterocyte	3 studies	17% ± 1%	Explore
enteroendocrine cell	3 studies	24% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	44% ± 12%	Explore
transit amplifying cell	3 studies	31% ± 16%	Explore
brush cell	3 studies	21% ± 6%	Explore
T-helper 17 cell	3 studies	26% ± 8%	Explore
T-helper 1 cell	3 studies	30% ± 10%	Explore
double negative thymocyte	3 studies	40% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	15 studies	28% ± 11%	Explore
brain	12 studies	34% ± 19%	Explore
lung	11 studies	25% ± 6%	Explore
intestine	8 studies	21% ± 6%	Explore
eye	7 studies	22% ± 9%	Explore
kidney	4 studies	20% ± 3%	Explore
bone marrow	4 studies	23% ± 4%	Explore
liver	4 studies	29% ± 11%	Explore
adipose	4 studies	21% ± 2%	Explore
pancreas	3 studies	43% ± 18%	Explore
uterus	3 studies	35% ± 14%	Explore
lymph node	3 studies	26% ± 6%	Explore
breast	3 studies	25% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6423.23	1445 / 1445	100%	70.57	183 / 183
lung	100%	6690.69	578 / 578	100%	72.90	1155 / 1155
ovary	100%	7229.08	180 / 180	100%	58.84	430 / 430
breast	100%	6814.09	459 / 459	100%	102.63	1117 / 1118
intestine	100%	6329.16	966 / 966	100%	65.75	526 / 527
prostate	100%	5799.15	245 / 245	100%	72.61	501 / 502
stomach	100%	4905.81	359 / 359	100%	63.16	285 / 286
bladder	100%	6553.95	21 / 21	100%	66.72	502 / 504
uterus	100%	6876.83	170 / 170	100%	69.47	457 / 459
pancreas	100%	4068.83	328 / 328	99%	60.64	177 / 178
thymus	100%	6421.59	653 / 653	99%	68.19	600 / 605
brain	99%	3917.26	2609 / 2642	100%	45.73	705 / 705
kidney	100%	4962.96	89 / 89	98%	56.41	882 / 901
liver	100%	4161.99	226 / 226	98%	42.89	397 / 406
adrenal gland	100%	8354.19	258 / 258	97%	55.43	223 / 230
skin	100%	8396.83	1809 / 1809	97%	64.61	456 / 472
adipose	100%	7247.83	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7072.30	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	57.30	29 / 29
muscle	100%	8860.07	803 / 803	0%	0	0 / 0
spleen	100%	5604.99	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	66.29	45 / 45
ureter	0%	0	0 / 0	100%	22.66	1 / 1
heart	98%	5596.97	841 / 861	0%	0	0 / 0
peripheral blood	97%	6134.82	904 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	94%	40.30	75 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0034982	Biological process	mitochondrial protein processing
GO_0097150	Biological process	neuronal stem cell population maintenance
GO_0008283	Biological process	cell population proliferation
GO_0035694	Biological process	mitochondrial protein catabolic process
GO_0010636	Biological process	positive regulation of mitochondrial fusion
GO_0009267	Biological process	cellular response to starvation
GO_0007005	Biological process	mitochondrion organization
GO_0043066	Biological process	negative regulation of apoptotic process
GO_2000035	Biological process	regulation of stem cell division
GO_0034214	Biological process	protein hexamerization
GO_0006515	Biological process	protein quality control for misfolded or incompletely synthesized proteins
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0016604	Cellular component	nuclear body
GO_0004176	Molecular function	ATP-dependent peptidase activity
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0004222	Molecular function	metalloendopeptidase activity
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	YME1L1
Protein name	YME1-like 1 (S. cerevisiae) YME1 like 1 ATPase (YME1L1 protein) YME1 like 1 ATPase ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1)
Synonyms	FTSH1 YME1L UNQ1868/PRO4304
Description	FUNCTION: ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region . Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism . Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins . Required for normal, constitutive degradation of PRELID1 . Catalyzes the degradation of OMA1 in response to membrane depolarization . Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) . .
Accessions	Q96TA2 R4GNA5 ENST00000396296.7 ENST00000376016.8 [Q96TA2-2] Q5T8D2 Q6PJ89 ENST00000326799.7 [Q96TA2-1] Q5T8D1 ENST00000427324.5 ENST00000613434.4 [Q96TA2-3] ENST00000477432.1 ENST00000491542.6 Q96I63

YME1L1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review