PCID2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043488Biological processregulation of mRNA stability
GO_2000117Biological processnegative regulation of cysteine-type endopeptidase activity
GO_0006368Biological processtranscription elongation by RNA polymerase II
GO_0045579Biological processpositive regulation of B cell differentiation
GO_0048536Biological processspleen development
GO_0070828Biological processheterochromatin organization
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0090267Biological processpositive regulation of mitotic cell cycle spindle assembly checkpoint
GO_0015031Biological processprotein transport
GO_0000973Biological processpost-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
GO_0016973Biological processpoly(A)+ mRNA export from nucleus
GO_1905457Biological processnegative regulation of lymphoid progenitor cell differentiation
GO_0060633Biological processnegative regulation of transcription initiation by RNA polymerase II
GO_0005634Cellular componentnucleus
GO_0070390Cellular componenttranscription export complex 2
GO_0044615Cellular componentnuclear pore nuclear basket
GO_0005737Cellular componentcytoplasm
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePCID2
Protein namePCI domain-containing protein 2 (CSN12-like protein)
HCG2012301 (PCID2 protein)
SynonymsHT004
hCG_2012301
DescriptionFUNCTION: Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores . Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability . Blocks the activity of the SRCAP chromatin remodeling complex by interacting with SRCAP complex member ZNHIT1 and inhibiting its interaction with the complex (By similarity). This prevents the deposition of histone variant H2AZ1/H2A.Z at the nucleosomes of key lymphoid fate regulator genes which suppresses their expression and restricts lymphoid lineage commitment (By similarity). .

AccessionsENST00000375459.5 [Q5JVF3-2]
ENST00000375479.6 [Q5JVF3-1]
ENST00000622406.4 [Q5JVF3-4]
ENST00000375477.5 [Q5JVF3-1]
Q5JVF3
ENST00000246505.9 [Q5JVF3-4]
ENST00000337344.9 [Q5JVF3-1]
ENST00000375457.2 [Q5JVF3-2]
Q96H21