TNFSF18 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of TNFSF18 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	91%	20.51	2407 / 2642	66%	4.60	465 / 705
lung	88%	13.76	507 / 578	49%	2.43	570 / 1155
esophagus	87%	32.49	1261 / 1445	46%	2.74	85 / 183
thymus	68%	9.18	444 / 653	45%	1.83	271 / 605
intestine	60%	6.23	581 / 966	23%	0.61	121 / 527
stomach	52%	4.93	185 / 359	31%	0.99	89 / 286
breast	52%	5.28	240 / 459	28%	0.63	318 / 1118
pancreas	29%	1.78	96 / 328	51%	1.51	91 / 178
skin	64%	14.06	1158 / 1809	13%	0.32	63 / 472
spleen	77%	7.54	186 / 241	0%	0	0 / 0
kidney	47%	5.48	42 / 89	27%	0.72	246 / 901
adipose	69%	7.26	831 / 1204	0%	0	0 / 0
prostate	65%	5.69	159 / 245	3%	0.06	17 / 502
tonsil	0%	0	0 / 0	64%	2.73	29 / 45
adrenal gland	47%	5.45	122 / 258	14%	0.33	33 / 230
heart	57%	4.92	487 / 861	0%	0	0 / 0
bladder	33%	2.95	7 / 21	19%	0.59	95 / 504
uterus	22%	1.42	38 / 170	19%	0.82	86 / 459
blood vessel	41%	4.01	545 / 1335	0%	0	0 / 0
ovary	28%	1.86	50 / 180	10%	0.20	43 / 430
liver	25%	1.59	56 / 226	12%	0.22	50 / 406
muscle	27%	1.38	213 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	21%	0.43	6 / 29
peripheral blood	12%	0.78	110 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0042531	Biological process	positive regulation of tyrosine phosphorylation of STAT protein
GO_0007165	Biological process	signal transduction
GO_0042129	Biological process	regulation of T cell proliferation
GO_0045785	Biological process	positive regulation of cell adhesion
GO_0007267	Biological process	cell-cell signaling
GO_0051092	Biological process	positive regulation of NF-kappaB transcription factor activity
GO_0002250	Biological process	adaptive immune response
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0002687	Biological process	positive regulation of leukocyte migration
GO_0002309	Biological process	T cell proliferation involved in immune response
GO_0033209	Biological process	tumor necrosis factor-mediated signaling pathway
GO_0005615	Cellular component	extracellular space
GO_0005886	Cellular component	plasma membrane
GO_0009986	Cellular component	cell surface
GO_0032813	Molecular function	tumor necrosis factor receptor superfamily binding
GO_0042802	Molecular function	identical protein binding
GO_0005102	Molecular function	signaling receptor binding
GO_0005515	Molecular function	protein binding
GO_0005125	Molecular function	cytokine activity

Gene name	TNFSF18
Protein name	Tumor necrosis factor ligand superfamily member 18 (Activation-inducible TNF-related ligand) (AITRL) (Glucocorticoid-induced TNF-related ligand) (hGITRL)
Synonyms	AITRL UNQ149/PRO175 TL6 GITRL
Description	FUNCTION: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 . Promotes leukocyte adhesion to endothelial cells . Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity). .
Accessions	Q9UNG2 ENST00000404377.5

TNFSF18 report