LACRT | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LACRT at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	48%	6.00	875 / 1809	0%	0	0 / 472
breast	15%	3.21	69 / 459	12%	46.79	133 / 1118
adipose	4%	0.35	52 / 1204	0%	0	0 / 0
kidney	3%	0.08	3 / 89	0%	0	0 / 901
stomach	2%	0.04	7 / 359	0%	0.01	1 / 286
pancreas	1%	0.03	4 / 328	1%	0.01	1 / 178
prostate	2%	0.07	4 / 245	0%	0	0 / 502
intestine	1%	0.03	11 / 966	0%	0.01	2 / 527
blood vessel	1%	0.03	15 / 1335	0%	0	0 / 0
lung	1%	0.02	4 / 578	0%	0.00	3 / 1155
heart	1%	0.05	8 / 861	0%	0	0 / 0
thymus	1%	0.02	6 / 653	0%	0	0 / 605
brain	1%	0.02	24 / 2642	0%	0	0 / 705
spleen	1%	0.02	2 / 241	0%	0	0 / 0
esophagus	1%	0.02	10 / 1445	0%	0	0 / 183
uterus	0%	0	0 / 170	1%	0.01	3 / 459
peripheral blood	1%	0.02	6 / 929	0%	0	0 / 0
muscle	0%	0.01	4 / 803	0%	0	0 / 0
adrenal gland	0%	0	0 / 258	0%	0.01	1 / 230
bladder	0%	0	0 / 21	0%	0.03	2 / 504
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
liver	0%	0	0 / 226	0%	0	0 / 406
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
ovary	0%	0	0 / 180	0%	0	0 / 430
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0060054	Biological process	positive regulation of epithelial cell proliferation involved in wound healing
GO_0010669	Biological process	epithelial structure maintenance
GO_0050850	Biological process	positive regulation of calcium-mediated signaling
GO_0019722	Biological process	calcium-mediated signaling
GO_0070075	Biological process	tear secretion
GO_0070886	Biological process	positive regulation of calcineurin-NFAT signaling cascade
GO_0033173	Biological process	calcineurin-NFAT signaling cascade
GO_0034067	Biological process	protein localization to Golgi apparatus
GO_0050679	Biological process	positive regulation of epithelial cell proliferation
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0050731	Biological process	positive regulation of peptidyl-tyrosine phosphorylation
GO_0016239	Biological process	positive regulation of macroautophagy
GO_0042742	Biological process	defense response to bacterium
GO_0031665	Biological process	negative regulation of lipopolysaccharide-mediated signaling pathway
GO_0051281	Biological process	positive regulation of release of sequestered calcium ion into cytosol
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0051047	Biological process	positive regulation of secretion
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0030141	Cellular component	secretory granule
GO_0008083	Molecular function	growth factor activity
GO_0043237	Molecular function	laminin-1 binding
GO_0005518	Molecular function	collagen binding
GO_0005515	Molecular function	protein binding

Gene name	LACRT
Protein name	Extracellular glycoprotein lacritin Lacritin
Synonyms
Description	FUNCTION: Modulates secretion by lacrimal acinar cells.
Accessions	ENST00000547511.5 F8W0V3 ENST00000546721.5 Q9GZZ8 ENST00000257867.5 H0YI00

LACRT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review