HSP90AB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030511Biological processpositive regulation of transforming growth factor beta receptor signaling pathway
GO_0006986Biological processresponse to unfolded protein
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0034605Biological processcellular response to heat
GO_0061077Biological processchaperone-mediated protein folding
GO_0032880Biological processregulation of protein localization
GO_0071353Biological processcellular response to interleukin-4
GO_1901799Biological processnegative regulation of proteasomal protein catabolic process
GO_2000010Biological processpositive regulation of protein localization to cell surface
GO_0001890Biological processplacenta development
GO_0031396Biological processregulation of protein ubiquitination
GO_0051131Biological processchaperone-mediated protein complex assembly
GO_0006457Biological processprotein folding
GO_0097435Biological processsupramolecular fiber organization
GO_0007004Biological processtelomere maintenance via telomerase
GO_0045597Biological processpositive regulation of cell differentiation
GO_0043066Biological processnegative regulation of apoptotic process
GO_1905323Biological processtelomerase holoenzyme complex assembly
GO_0050821Biological processprotein stabilization
GO_0045429Biological processpositive regulation of nitric oxide biosynthetic process
GO_0019062Biological processvirion attachment to host cell
GO_0032516Biological processpositive regulation of phosphoprotein phosphatase activity
GO_0051726Biological processregulation of cell cycle
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0043025Cellular componentneuronal cell body
GO_0034774Cellular componentsecretory granule lumen
GO_0120293Cellular componentdynein axonemal particle
GO_0009986Cellular componentcell surface
GO_0101031Cellular componentprotein folding chaperone complex
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0044294Cellular componentdendritic growth cone
GO_0008180Cellular componentCOP9 signalosome
GO_0044295Cellular componentaxonal growth cone
GO_0005737Cellular componentcytoplasm
GO_0034751Cellular componentaryl hydrocarbon receptor complex
GO_1990565Cellular componentHSP90-CDC37 chaperone complex
GO_0042470Cellular componentmelanosome
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0030911Molecular functionTPR domain binding
GO_0141069Molecular functionreceptor ligand inhibitor activity
GO_0070182Molecular functionDNA polymerase binding
GO_0019887Molecular functionprotein kinase regulator activity
GO_0044183Molecular functionprotein folding chaperone
GO_0042277Molecular functionpeptide binding
GO_0019900Molecular functionkinase binding
GO_0045296Molecular functioncadherin binding
GO_0031072Molecular functionheat shock protein binding
GO_0019901Molecular functionprotein kinase binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042802Molecular functionidentical protein binding
GO_0051082Molecular functionunfolded protein binding
GO_0043008Molecular functionATP-dependent protein binding
GO_0030235Molecular functionnitric-oxide synthase regulator activity
GO_0140662Molecular functionATP-dependent protein folding chaperone
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0048156Molecular functiontau protein binding
GO_0023026Molecular functionMHC class II protein complex binding
GO_0046983Molecular functionprotein dimerization activity
GO_0097718Molecular functiondisordered domain specific binding
GO_0005515Molecular functionprotein binding
GO_1990226Molecular functionhistone methyltransferase binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0003725Molecular functiondouble-stranded RNA binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameHSP90AB1
Protein nameHeat shock protein HSP 90-beta
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84)
SynonymsHSP90B
HSPC2
HSPCB
DescriptionFUNCTION: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function . Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle . Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression . Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation . Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery . Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription . Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10 . .; FUNCTION: (Microbial infection) Binding to N.meningitidis NadA stimulates monocytes . Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable). .

AccessionsENST00000620073.4
ENST00000353801.7
P08238
ENST00000371646.10
ENST00000371554.2
Q6PK50