I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| macrophage | 5 studies | 20% ± 4% | |
| monocyte | 3 studies | 16% ± 1% | |
| myeloid cell | 3 studies | 18% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| macrophage | 5 studies | 20% ± 4% | |
| monocyte | 3 studies | 16% ± 1% | |
| myeloid cell | 3 studies | 18% ± 2% |
Insufficient scRNA-seq data for expression of IL10 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 90% | 32.20 | 520 / 578 | 21% | 0.36 | 241 / 1155 |
| ovary | 49% | 8.96 | 89 / 180 | 52% | 1.29 | 223 / 430 |
| spleen | 98% | 84.31 | 235 / 241 | 0% | 0 | 0 / 0 |
| adrenal gland | 86% | 21.56 | 223 / 258 | 9% | 0.23 | 21 / 230 |
| peripheral blood | 93% | 64.87 | 863 / 929 | 0% | 0 | 0 / 0 |
| adipose | 90% | 51.67 | 1082 / 1204 | 0% | 0 | 0 / 0 |
| intestine | 80% | 17.72 | 774 / 966 | 9% | 0.69 | 48 / 527 |
| breast | 73% | 16.52 | 334 / 459 | 16% | 0.36 | 182 / 1118 |
| lymph node | 0% | 0 | 0 / 0 | 86% | 13.49 | 25 / 29 |
| bladder | 71% | 10.43 | 15 / 21 | 15% | 0.28 | 74 / 504 |
| stomach | 59% | 12.88 | 212 / 359 | 16% | 0.32 | 45 / 286 |
| esophagus | 54% | 9.94 | 776 / 1445 | 13% | 0.20 | 24 / 183 |
| blood vessel | 55% | 18.78 | 740 / 1335 | 0% | 0 | 0 / 0 |
| uterus | 32% | 4.78 | 54 / 170 | 23% | 0.54 | 106 / 459 |
| thymus | 45% | 5.43 | 294 / 653 | 4% | 0.08 | 25 / 605 |
| heart | 49% | 13.07 | 419 / 861 | 0% | 0 | 0 / 0 |
| kidney | 30% | 4.53 | 27 / 89 | 14% | 0.25 | 126 / 901 |
| skin | 17% | 1.74 | 311 / 1809 | 27% | 0.60 | 128 / 472 |
| prostate | 42% | 5.23 | 103 / 245 | 1% | 0.02 | 7 / 502 |
| brain | 20% | 2.38 | 518 / 2642 | 17% | 0.47 | 119 / 705 |
| liver | 31% | 6.33 | 71 / 226 | 2% | 0.05 | 7 / 406 |
| pancreas | 16% | 1.38 | 53 / 328 | 13% | 0.23 | 24 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 11% | 0.13 | 5 / 45 |
| muscle | 7% | 0.55 | 58 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0010468 | Biological process | regulation of gene expression |
| GO_0071650 | Biological process | negative regulation of chemokine (C-C motif) ligand 5 production |
| GO_0002639 | Biological process | positive regulation of immunoglobulin production |
| GO_0045347 | Biological process | negative regulation of MHC class II biosynthetic process |
| GO_1903377 | Biological process | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
| GO_1903034 | Biological process | regulation of response to wounding |
| GO_0071392 | Biological process | cellular response to estradiol stimulus |
| GO_1903672 | Biological process | positive regulation of sprouting angiogenesis |
| GO_0014823 | Biological process | response to activity |
| GO_0034115 | Biological process | negative regulation of heterotypic cell-cell adhesion |
| GO_0032701 | Biological process | negative regulation of interleukin-18 production |
| GO_0051045 | Biological process | negative regulation of membrane protein ectodomain proteolysis |
| GO_0050728 | Biological process | negative regulation of inflammatory response |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_1902895 | Biological process | positive regulation of miRNA transcription |
| GO_0032689 | Biological process | negative regulation of type II interferon production |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0032720 | Biological process | negative regulation of tumor necrosis factor production |
| GO_0002904 | Biological process | positive regulation of B cell apoptotic process |
| GO_1904707 | Biological process | positive regulation of vascular associated smooth muscle cell proliferation |
| GO_0030183 | Biological process | B cell differentiation |
| GO_0030889 | Biological process | negative regulation of B cell proliferation |
| GO_0042092 | Biological process | type 2 immune response |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_2000352 | Biological process | negative regulation of endothelial cell apoptotic process |
| GO_0045348 | Biological process | positive regulation of MHC class II biosynthetic process |
| GO_0002875 | Biological process | negative regulation of chronic inflammatory response to antigenic stimulus |
| GO_0030886 | Biological process | negative regulation of myeloid dendritic cell activation |
| GO_0032715 | Biological process | negative regulation of interleukin-6 production |
| GO_2000273 | Biological process | positive regulation of signaling receptor activity |
| GO_0032695 | Biological process | negative regulation of interleukin-12 production |
| GO_0043032 | Biological process | positive regulation of macrophage activation |
| GO_0014854 | Biological process | response to inactivity |
| GO_0072577 | Biological process | endothelial cell apoptotic process |
| GO_0050807 | Biological process | regulation of synapse organization |
| GO_0097421 | Biological process | liver regeneration |
| GO_0042130 | Biological process | negative regulation of T cell proliferation |
| GO_1903659 | Biological process | regulation of complement-dependent cytotoxicity |
| GO_0032717 | Biological process | negative regulation of interleukin-8 production |
| GO_0060670 | Biological process | branching involved in labyrinthine layer morphogenesis |
| GO_0071222 | Biological process | cellular response to lipopolysaccharide |
| GO_0001819 | Biological process | positive regulation of cytokine production |
| GO_0045930 | Biological process | negative regulation of mitotic cell cycle |
| GO_0002719 | Biological process | negative regulation of cytokine production involved in immune response |
| GO_0002439 | Biological process | chronic inflammatory response to antigenic stimulus |
| GO_0045787 | Biological process | positive regulation of cell cycle |
| GO_0030097 | Biological process | hemopoiesis |
| GO_0051091 | Biological process | positive regulation of DNA-binding transcription factor activity |
| GO_0002237 | Biological process | response to molecule of bacterial origin |
| GO_0060302 | Biological process | negative regulation of cytokine activity |
| GO_0030595 | Biological process | leukocyte chemotaxis |
| GO_0045191 | Biological process | regulation of isotype switching |
| GO_0007253 | Biological process | cytoplasmic sequestering of NF-kappaB |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0001818 | Biological process | negative regulation of cytokine production |
| GO_0034116 | Biological process | positive regulation of heterotypic cell-cell adhesion |
| GO_0042100 | Biological process | B cell proliferation |
| GO_0046427 | Biological process | positive regulation of receptor signaling pathway via JAK-STAT |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0034465 | Biological process | response to carbon monoxide |
| GO_0032692 | Biological process | negative regulation of interleukin-1 production |
| GO_0032687 | Biological process | negative regulation of interferon-alpha production |
| GO_1904706 | Biological process | negative regulation of vascular associated smooth muscle cell proliferation |
| GO_0042832 | Biological process | defense response to protozoan |
| GO_0035729 | Biological process | cellular response to hepatocyte growth factor stimulus |
| GO_0032868 | Biological process | response to insulin |
| GO_0045019 | Biological process | negative regulation of nitric oxide biosynthetic process |
| GO_0140105 | Biological process | interleukin-10-mediated signaling pathway |
| GO_0051384 | Biological process | response to glucocorticoid |
| GO_0001938 | Biological process | positive regulation of endothelial cell proliferation |
| GO_0042742 | Biological process | defense response to bacterium |
| GO_0010507 | Biological process | negative regulation of autophagy |
| GO_1900100 | Biological process | positive regulation of plasma cell differentiation |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005125 | Molecular function | cytokine activity |
| GO_0046983 | Molecular function | protein dimerization activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0005141 | Molecular function | interleukin-10 receptor binding |
| GO_0008083 | Molecular function | growth factor activity |
| Gene name | IL10 |
| Protein name | Interleukin 10 Interleukin family protein Interleukin-10 (IL-10) (Cytokine synthesis inhibitory factor) (CSIF) |
| Synonyms | hCG_22208 IF2A |
| Description | FUNCTION: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 . In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators . Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha . Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation . In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity). . FUNCTION: Immune regulatory cytokine. . FUNCTION: Immune regulatory cytokine. . FUNCTION: Immune regulatory cytokine. . FUNCTION: Immune regulatory cytokine. . FUNCTION: Immune regulatory cytokine. . FUNCTION: Immune regulatory cytokine. . |
| Accessions | B3VI66 Q71UZ1 A0A590UK12 ENST00000471071.2 ENST00000659065.2 ENST00000659642.2 P22301 Q6LBF4 Q6FGW4 ENST00000423557.1 ENST00000664374.2 Q6FGS9 A0A286YEX3 |
