AKR1B1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044597Biological processdaunorubicin metabolic process
GO_0003091Biological processrenal water homeostasis
GO_0044598Biological processdoxorubicin metabolic process
GO_0019853Biological processL-ascorbic acid biosynthetic process
GO_0035809Biological processregulation of urine volume
GO_0072205Biological processmetanephric collecting duct development
GO_0005975Biological processcarbohydrate metabolic process
GO_0006700Biological processC21-steroid hormone biosynthetic process
GO_0002070Biological processepithelial cell maturation
GO_0071475Biological processcellular hyperosmotic salinity response
GO_0001523Biological processretinoid metabolic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0042572Biological processretinol metabolic process
GO_0006693Biological processprostaglandin metabolic process
GO_0046370Biological processfructose biosynthetic process
GO_0005615Cellular componentextracellular space
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0047655Molecular functionallyl-alcohol dehydrogenase activity
GO_0004032Molecular functionaldose reductase (NADPH) activity
GO_0043795Molecular functionglyceraldehyde oxidoreductase activity
GO_0009055Molecular functionelectron transfer activity
GO_0001758Molecular functionretinal dehydrogenase activity
GO_0036130Molecular functionprostaglandin H2 endoperoxidase reductase activity
GO_0052650Molecular functionall-trans-retinol dehydrogenase (NADP+) activity
GO_0047939Molecular functionL-glucuronate reductase activity
GO_0047956Molecular functionglycerol dehydrogenase (NADP+) activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAKR1B1
Protein nameAldo-keto reductase family 1 member B1 (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) (EC 1.1.1.21)
Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (Aldose reductase)
SynonymsALR2
ALDR1
DescriptionFUNCTION: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia . Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal . Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides . Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) . .

AccessionsE9PEF9
E9PCX2
ENST00000426422.1
ENST00000434222.5
P15121
ENST00000285930.9