Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 13 studies | 36% ± 26% | |
| pericyte | 10 studies | 29% ± 24% | |
| Mueller cell | 5 studies | 22% ± 4% | |
| astrocyte | 4 studies | 26% ± 6% | |
| hepatic stellate cell | 3 studies | 42% ± 2% | |
| macrophage | 3 studies | 18% ± 1% |
Insufficient scRNA-seq data for expression of HGF at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 3694.43 | 578 / 578 | 77% | 3.76 | 885 / 1155 |
| prostate | 97% | 1287.50 | 237 / 245 | 77% | 2.98 | 389 / 502 |
| breast | 97% | 1093.56 | 444 / 459 | 72% | 2.36 | 809 / 1118 |
| kidney | 93% | 1401.33 | 83 / 89 | 74% | 6.71 | 667 / 901 |
| adrenal gland | 100% | 2329.95 | 258 / 258 | 47% | 3.07 | 109 / 230 |
| liver | 100% | 1762.61 | 226 / 226 | 46% | 2.56 | 188 / 406 |
| bladder | 95% | 1598.76 | 20 / 21 | 40% | 2.52 | 202 / 504 |
| thymus | 99% | 1335.85 | 647 / 653 | 35% | 0.62 | 211 / 605 |
| stomach | 65% | 354.08 | 233 / 359 | 63% | 2.15 | 181 / 286 |
| uterus | 98% | 1004.09 | 166 / 170 | 29% | 2.85 | 134 / 459 |
| esophagus | 71% | 512.08 | 1023 / 1445 | 55% | 3.00 | 101 / 183 |
| intestine | 74% | 547.41 | 713 / 966 | 48% | 1.31 | 251 / 527 |
| pancreas | 23% | 84.52 | 75 / 328 | 78% | 2.93 | 138 / 178 |
| blood vessel | 99% | 1644.29 | 1326 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 99% | 965.61 | 239 / 241 | 0% | 0 | 0 / 0 |
| adipose | 97% | 1267.70 | 1170 / 1204 | 0% | 0 | 0 / 0 |
| brain | 29% | 159.46 | 761 / 2642 | 56% | 2.60 | 392 / 705 |
| skin | 42% | 740.61 | 760 / 1809 | 37% | 3.24 | 175 / 472 |
| heart | 72% | 472.48 | 617 / 861 | 0% | 0 | 0 / 0 |
| ovary | 39% | 252.99 | 70 / 180 | 18% | 0.59 | 77 / 430 |
| peripheral blood | 56% | 467.50 | 521 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 34% | 0.64 | 10 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 16% | 0.90 | 7 / 45 |
| muscle | 9% | 33.47 | 72 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 6% | 0.15 | 5 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0050673 | Biological process | epithelial cell proliferation |
| GO_0060665 | Biological process | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling |
| GO_0001837 | Biological process | epithelial to mesenchymal transition |
| GO_0000278 | Biological process | mitotic cell cycle |
| GO_0014856 | Biological process | skeletal muscle cell proliferation |
| GO_0032715 | Biological process | negative regulation of interleukin-6 production |
| GO_0050918 | Biological process | positive chemotaxis |
| GO_0035729 | Biological process | cellular response to hepatocyte growth factor stimulus |
| GO_0090201 | Biological process | negative regulation of release of cytochrome c from mitochondria |
| GO_0001889 | Biological process | liver development |
| GO_0032733 | Biological process | positive regulation of interleukin-10 production |
| GO_0001934 | Biological process | positive regulation of protein phosphorylation |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0045669 | Biological process | positive regulation of osteoblast differentiation |
| GO_0050728 | Biological process | negative regulation of inflammatory response |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0051450 | Biological process | myoblast proliferation |
| GO_2000573 | Biological process | positive regulation of DNA biosynthetic process |
| GO_0006508 | Biological process | proteolysis |
| GO_1900744 | Biological process | regulation of p38MAPK cascade |
| GO_1901299 | Biological process | negative regulation of hydrogen peroxide-mediated programmed cell death |
| GO_0010507 | Biological process | negative regulation of autophagy |
| GO_0048012 | Biological process | hepatocyte growth factor receptor signaling pathway |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_1902042 | Biological process | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| GO_0033137 | Biological process | negative regulation of peptidyl-serine phosphorylation |
| GO_0000902 | Biological process | cell morphogenesis |
| GO_0060326 | Biological process | cell chemotaxis |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0016020 | Cellular component | membrane |
| GO_0031093 | Cellular component | platelet alpha granule lumen |
| GO_0004175 | Molecular function | endopeptidase activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0042056 | Molecular function | chemoattractant activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0004252 | Molecular function | serine-type endopeptidase activity |
| Gene name | HGF |
| Protein name | Hepatocyte growth factor (Hepatopoietin-A) (Scatter factor) (SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain] Hepatocyte growth factor |
| Synonyms | HPTA |
| Description | FUNCTION: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types . Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization . Activates MAPK signaling following TMPRSS13 cleavage and activation . . |
| Accessions | ENST00000222390.11 [P14210-1] ENST00000444829.7 [P14210-2] ENST00000421558.1 ENST00000423064.7 [P14210-6] A0A2R8YEI1 C9JS80 C9WSJ3 ENST00000643024.1 C9JDP4 C9WSJ4 ENST00000453411.6 [P14210-5] P14210 ENST00000354224.10 ENST00000465234.2 ENST00000457544.7 [P14210-3] ENST00000412881.5 |
