DNAJA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905259Biological processnegative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
GO_0006986Biological processresponse to unfolded protein
GO_0009408Biological processresponse to heat
GO_0007283Biological processspermatogenesis
GO_0070585Biological processprotein localization to mitochondrion
GO_0051223Biological processregulation of protein transport
GO_0043508Biological processnegative regulation of JUN kinase activity
GO_0006457Biological processprotein folding
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030317Biological processflagellated sperm motility
GO_0042026Biological processprotein refolding
GO_1903748Biological processnegative regulation of establishment of protein localization to mitochondrion
GO_0030521Biological processandrogen receptor signaling pathway
GO_0043065Biological processpositive regulation of apoptotic process
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0098554Cellular componentcytoplasmic side of endoplasmic reticulum membrane
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0055131Molecular functionC3HC4-type RING finger domain binding
GO_0030957Molecular functionTat protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0051082Molecular functionunfolded protein binding
GO_0001664Molecular functionG protein-coupled receptor binding
GO_0050750Molecular functionlow-density lipoprotein particle receptor binding
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0030544Molecular functionHsp70 protein binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0001671Molecular functionATPase activator activity

IV. Literature review

[source]
Gene nameDNAJA1
Protein nameDnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2)
SynonymsHSJ2
DNAJ2
HDJ2
HSPF4
DescriptionFUNCTION: Co-chaperone for HSPA8/Hsc70 . Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) . Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as a co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis . Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV . .

AccessionsP31689
ENST00000330899.5 [P31689-1]