FMN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042177Biological processnegative regulation of protein catabolic process
GO_0046907Biological processintracellular transport
GO_0051758Biological processhomologous chromosome movement towards spindle pole in meiosis I anaphase
GO_0006974Biological processDNA damage response
GO_0030036Biological processactin cytoskeleton organization
GO_0016192Biological processvesicle-mediated transport
GO_0035556Biological processintracellular signal transduction
GO_0043066Biological processnegative regulation of apoptotic process
GO_0015031Biological processprotein transport
GO_0051295Biological processestablishment of meiotic spindle localization
GO_0070649Biological processformin-nucleated actin cable assembly
GO_2000781Biological processpositive regulation of double-strand break repair
GO_0048477Biological processoogenesis
GO_0040038Biological processpolar body extrusion after meiotic divisions
GO_0016477Biological processcell migration
GO_0071456Biological processcellular response to hypoxia
GO_0005902Cellular componentmicrovillus
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0015629Cellular componentactin cytoskeleton
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0005737Cellular componentcytoplasm
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_0003779Molecular functionactin binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameFMN2
Protein nameFormin 2
Formin-2
FMN2 protein
Synonyms
DescriptionFUNCTION: Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization . Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 . Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest . Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage . Protects cells against apoptosis by protecting CDKN1A against degradation . .

AccessionsB0QZA8
Q2M1H5
A0A7P0TA49
A0A7P0T8C5
ENST00000679980.1
ENST00000681131.1
ENST00000441342.1
A0A0A0MTF8
ENST00000545751.3
ENST00000447095.5
B0QZD5
Q96L17
ENST00000319653.14 [Q9NZ56-1]
ENST00000681741.1
ENST00000681210.1
Q9NZ56
A0A7P0T8F6
ENST00000681805.1
A0A7P0Z432
A0A7P0T994
A0A7P0T9J5
ENST00000681824.1