Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 19 studies | 70% ± 20% | |
glutamatergic neuron | 13 studies | 69% ± 24% | |
oligodendrocyte precursor cell | 13 studies | 41% ± 16% | |
GABAergic neuron | 11 studies | 62% ± 25% | |
neuron | 6 studies | 49% ± 20% | |
interneuron | 6 studies | 70% ± 21% | |
retina horizontal cell | 6 studies | 70% ± 25% | |
retinal cone cell | 5 studies | 51% ± 25% | |
endothelial cell | 4 studies | 43% ± 24% | |
granule cell | 4 studies | 53% ± 14% | |
microglial cell | 4 studies | 35% ± 19% | |
amacrine cell | 4 studies | 62% ± 8% | |
retinal ganglion cell | 4 studies | 45% ± 15% | |
ciliated cell | 4 studies | 32% ± 14% | |
oligodendrocyte | 4 studies | 32% ± 22% | |
GABAergic interneuron | 3 studies | 67% ± 5% | |
retinal bipolar neuron | 3 studies | 37% ± 15% | |
GABAergic amacrine cell | 3 studies | 56% ± 13% | |
OFF-bipolar cell | 3 studies | 49% ± 20% | |
ON-bipolar cell | 3 studies | 41% ± 16% | |
glycinergic amacrine cell | 3 studies | 48% ± 5% | |
ependymal cell | 3 studies | 73% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 3493.43 | 2639 / 2642 | 99% | 31.00 | 701 / 705 |
adrenal gland | 27% | 148.10 | 69 / 258 | 67% | 8.30 | 153 / 230 |
intestine | 63% | 709.65 | 612 / 966 | 3% | 0.12 | 17 / 527 |
kidney | 62% | 394.39 | 55 / 89 | 1% | 0.09 | 13 / 901 |
skin | 28% | 793.30 | 505 / 1809 | 26% | 2.02 | 123 / 472 |
ovary | 48% | 269.59 | 87 / 180 | 2% | 0.08 | 10 / 430 |
uterus | 28% | 153.24 | 47 / 170 | 7% | 0.42 | 33 / 459 |
eye | 0% | 0 | 0 / 0 | 34% | 1.99 | 27 / 80 |
pancreas | 0% | 2.53 | 1 / 328 | 16% | 1.20 | 29 / 178 |
prostate | 13% | 60.09 | 31 / 245 | 3% | 0.10 | 13 / 502 |
stomach | 8% | 37.96 | 29 / 359 | 5% | 0.18 | 15 / 286 |
adipose | 12% | 62.20 | 148 / 1204 | 0% | 0 | 0 / 0 |
esophagus | 6% | 37.28 | 91 / 1445 | 4% | 0.17 | 7 / 183 |
bladder | 5% | 17.43 | 1 / 21 | 2% | 0.13 | 8 / 504 |
thymus | 3% | 19.17 | 21 / 653 | 2% | 0.14 | 15 / 605 |
breast | 3% | 12.05 | 14 / 459 | 2% | 0.09 | 24 / 1118 |
lung | 0% | 1.20 | 1 / 578 | 4% | 0.14 | 44 / 1155 |
liver | 0% | 0 | 0 / 226 | 2% | 0.10 | 7 / 406 |
blood vessel | 0% | 1.38 | 4 / 1335 | 0% | 0 | 0 / 0 |
muscle | 0% | 0.82 | 1 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0042177 | Biological process | negative regulation of protein catabolic process |
GO_0046907 | Biological process | intracellular transport |
GO_0051758 | Biological process | homologous chromosome movement towards spindle pole in meiosis I anaphase |
GO_0006974 | Biological process | DNA damage response |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_0016192 | Biological process | vesicle-mediated transport |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_0015031 | Biological process | protein transport |
GO_0051295 | Biological process | establishment of meiotic spindle localization |
GO_0070649 | Biological process | formin-nucleated actin cable assembly |
GO_2000781 | Biological process | positive regulation of double-strand break repair |
GO_0048477 | Biological process | oogenesis |
GO_0040038 | Biological process | polar body extrusion after meiotic divisions |
GO_0016477 | Biological process | cell migration |
GO_0071456 | Biological process | cellular response to hypoxia |
GO_0005902 | Cellular component | microvillus |
GO_0005730 | Cellular component | nucleolus |
GO_0005886 | Cellular component | plasma membrane |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0015629 | Cellular component | actin cytoskeleton |
GO_0005783 | Cellular component | endoplasmic reticulum |
GO_0005829 | Cellular component | cytosol |
GO_0005938 | Cellular component | cell cortex |
GO_0005737 | Cellular component | cytoplasm |
GO_0030659 | Cellular component | cytoplasmic vesicle membrane |
GO_0005819 | Cellular component | spindle |
GO_0005634 | Cellular component | nucleus |
GO_0003779 | Molecular function | actin binding |
GO_0003674 | Molecular function | molecular_function |
Gene name | FMN2 |
Protein name | Formin 2 Formin-2 FMN2 protein |
Synonyms | |
Description | FUNCTION: Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization . Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 . Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest . Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage . Protects cells against apoptosis by protecting CDKN1A against degradation . . |
Accessions | B0QZA8 Q2M1H5 A0A7P0TA49 A0A7P0T8C5 ENST00000679980.1 ENST00000681131.1 ENST00000441342.1 A0A0A0MTF8 ENST00000545751.3 ENST00000447095.5 B0QZD5 Q96L17 ENST00000319653.14 [Q9NZ56-1] ENST00000681741.1 ENST00000681210.1 Q9NZ56 A0A7P0T8F6 ENST00000681805.1 A0A7P0Z432 A0A7P0T994 A0A7P0T9J5 ENST00000681824.1 |