FSTL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030510Biological processregulation of BMP signaling pathway
GO_0007275Biological processmulticellular organism development
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030154Biological processcell differentiation
GO_0043542Biological processendothelial cell migration
GO_0045446Biological processendothelial cell differentiation
GO_0061484Biological processhematopoietic stem cell homeostasis
GO_0005615Cellular componentextracellular space
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0008201Molecular functionheparin binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFSTL1
Protein nameFollistatin-related protein 1 (Follistatin-like protein 1)
Follistatin like 1
SynonymsFRP
DescriptionFUNCTION: Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation . Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (By similarity). Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors . .

AccessionsENST00000480823.1
Q12841
ENST00000469005.2 [Q12841-1]
ENST00000469005.1
ENST00000710954.1 [Q12841-1]
C9J5G4
ENST00000424703.6 [Q12841-2]
H7C4W4
ENST00000295633.8 [Q12841-1]