IL4 | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	84%	3.32	549 / 653	10%	0.21	60 / 605
spleen	92%	4.80	221 / 241	0%	0	0 / 0
prostate	90%	5.36	221 / 245	1%	0.01	4 / 502
lung	83%	4.35	478 / 578	3%	0.06	39 / 1155
kidney	83%	3.38	74 / 89	3%	0.04	25 / 901
ovary	85%	3.71	153 / 180	0%	0.01	2 / 430
uterus	84%	3.85	143 / 170	1%	0.01	3 / 459
adrenal gland	78%	2.24	201 / 258	4%	0.06	9 / 230
blood vessel	78%	3.32	1037 / 1335	0%	0	0 / 0
breast	75%	2.70	346 / 459	2%	0.03	25 / 1118
skin	74%	2.34	1333 / 1809	1%	0.02	6 / 472
adipose	69%	2.23	833 / 1204	0%	0	0 / 0
bladder	67%	1.95	14 / 21	1%	0.24	4 / 504
peripheral blood	66%	10.33	615 / 929	0%	0	0 / 0
intestine	60%	1.60	584 / 966	0%	0.01	2 / 527
pancreas	55%	1.29	181 / 328	4%	0.20	8 / 178
esophagus	59%	1.43	853 / 1445	1%	0.01	1 / 183
brain	55%	1.43	1462 / 2642	2%	0.02	11 / 705
stomach	53%	1.19	190 / 359	3%	0.07	10 / 286
heart	47%	1.01	401 / 861	0%	0	0 / 0
liver	34%	0.58	76 / 226	2%	0.03	7 / 406
lymph node	0%	0	0 / 0	31%	1.36	9 / 29
muscle	27%	0.41	218 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	1%	0.02	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0042531	Biological process	positive regulation of tyrosine phosphorylation of STAT protein
GO_0042102	Biological process	positive regulation of T cell proliferation
GO_0042092	Biological process	type 2 immune response
GO_0042976	Biological process	activation of Janus kinase activity
GO_0042116	Biological process	macrophage activation
GO_2000352	Biological process	negative regulation of endothelial cell apoptotic process
GO_0045348	Biological process	positive regulation of MHC class II biosynthetic process
GO_0045582	Biological process	positive regulation of T cell differentiation
GO_0032736	Biological process	positive regulation of interleukin-13 production
GO_0010628	Biological process	positive regulation of gene expression
GO_0008203	Biological process	cholesterol metabolic process
GO_1903845	Biological process	negative regulation of cellular response to transforming growth factor beta stimulus
GO_0042325	Biological process	regulation of phosphorylation
GO_0032733	Biological process	positive regulation of interleukin-10 production
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0097028	Biological process	dendritic cell differentiation
GO_0045191	Biological process	regulation of isotype switching
GO_0050776	Biological process	regulation of immune response
GO_2000553	Biological process	positive regulation of T-helper 2 cell cytokine production
GO_0150079	Biological process	negative regulation of neuroinflammatory response
GO_0035771	Biological process	interleukin-4-mediated signaling pathway
GO_1901857	Biological process	positive regulation of cellular respiration
GO_0048260	Biological process	positive regulation of receptor-mediated endocytosis
GO_0006955	Biological process	immune response
GO_0050728	Biological process	negative regulation of inflammatory response
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0030335	Biological process	positive regulation of cell migration
GO_0016239	Biological process	positive regulation of macroautophagy
GO_0048304	Biological process	positive regulation of isotype switching to IgG isotypes
GO_1900223	Biological process	positive regulation of amyloid-beta clearance
GO_1903660	Biological process	negative regulation of complement-dependent cytotoxicity
GO_0030890	Biological process	positive regulation of B cell proliferation
GO_2001171	Biological process	positive regulation of ATP biosynthetic process
GO_0043011	Biological process	myeloid dendritic cell differentiation
GO_0120162	Biological process	positive regulation of cold-induced thermogenesis
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0010633	Biological process	negative regulation of epithelial cell migration
GO_0032720	Biological process	negative regulation of tumor necrosis factor production
GO_0150076	Biological process	neuroinflammatory response
GO_0048295	Biological process	positive regulation of isotype switching to IgE isotypes
GO_0042110	Biological process	T cell activation
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0030183	Biological process	B cell differentiation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0045671	Biological process	negative regulation of osteoclast differentiation
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0008083	Molecular function	growth factor activity
GO_0005136	Molecular function	interleukin-4 receptor binding
GO_0005515	Molecular function	protein binding
GO_0005125	Molecular function	cytokine activity

IV. Literature review

[source]

Gene name	IL4
Protein name	Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Binetrakin) (Lymphocyte stimulatory factor 1) (Pitrakinra) Interleukin-4 (IL-4) (B-cell stimulatory factor 1) (Lymphocyte stimulatory factor 1) Interleukin-4 (B-cell stimulatory factor 1) (Lymphocyte stimulatory factor 1)
Synonyms	hCG_24113
Description	FUNCTION: Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses . Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1 . Regulates also the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes . Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. In addition, plays a critical role in higher functions of the normal brain, such as memory and learning (By similarity). Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is expressed also on nonhematopoietic cells . Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6 . . FUNCTION: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. . FUNCTION: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. . FUNCTION: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. . FUNCTION: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. .
Accessions	D4HNR6 ENST00000231449.7 [P05112-1] U3LVN1 ENST00000350025.2 [P05112-2] P05112 ENST00000622422.1 Q6NWP0 B0JFA2 Q5FC01 Q9UPB9

IL4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review