DDAH2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	33 studies	37% ± 18%	Explore
macrophage	26 studies	31% ± 10%	Explore
endothelial cell	24 studies	34% ± 19%	Explore
smooth muscle cell	23 studies	36% ± 14%	Explore
pericyte	23 studies	36% ± 16%	Explore
B cell	18 studies	24% ± 8%	Explore
mast cell	18 studies	35% ± 14%	Explore
plasmacytoid dendritic cell	16 studies	33% ± 12%	Explore
connective tissue cell	16 studies	44% ± 21%	Explore
conventional dendritic cell	16 studies	27% ± 9%	Explore
endothelial cell of lymphatic vessel	13 studies	35% ± 13%	Explore
memory B cell	13 studies	21% ± 5%	Explore
non-classical monocyte	12 studies	23% ± 8%	Explore
myofibroblast cell	12 studies	48% ± 13%	Explore
epithelial cell	12 studies	39% ± 22%	Explore
endothelial cell of artery	11 studies	32% ± 17%	Explore
dendritic cell	10 studies	31% ± 14%	Explore
capillary endothelial cell	10 studies	32% ± 16%	Explore
ciliated cell	10 studies	30% ± 15%	Explore
vein endothelial cell	9 studies	32% ± 20%	Explore
endothelial cell of vascular tree	9 studies	26% ± 8%	Explore
monocyte	8 studies	23% ± 12%	Explore
myeloid cell	8 studies	27% ± 8%	Explore
basal cell	8 studies	28% ± 11%	Explore
naive B cell	7 studies	20% ± 6%	Explore
hematopoietic stem cell	7 studies	47% ± 11%	Explore
classical monocyte	6 studies	23% ± 5%	Explore
abnormal cell	6 studies	31% ± 13%	Explore
mesothelial cell	6 studies	56% ± 18%	Explore
neuron	6 studies	55% ± 28%	Explore
alveolar macrophage	5 studies	22% ± 4%	Explore
natural killer cell	5 studies	18% ± 2%	Explore
type I pneumocyte	5 studies	32% ± 17%	Explore
kidney loop of Henle epithelial cell	5 studies	26% ± 10%	Explore
progenitor cell	5 studies	44% ± 17%	Explore
enteroendocrine cell	5 studies	39% ± 14%	Explore
precursor B cell	5 studies	39% ± 12%	Explore
pro-B cell	5 studies	40% ± 5%	Explore
immature B cell	5 studies	35% ± 18%	Explore
hematopoietic precursor cell	4 studies	54% ± 17%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	57% ± 20%	Explore
leukocyte	4 studies	20% ± 3%	Explore
adventitial cell	4 studies	37% ± 11%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	26% ± 6%	Explore
granulocyte	4 studies	37% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	49% ± 23%	Explore
secretory cell	4 studies	27% ± 6%	Explore
glomerular endothelial cell	3 studies	19% ± 1%	Explore
epithelial cell of proximal tubule	3 studies	33% ± 22%	Explore
renal alpha-intercalated cell	3 studies	35% ± 14%	Explore
enterocyte	3 studies	17% ± 1%	Explore
neural crest cell	3 studies	48% ± 8%	Explore
astrocyte	3 studies	35% ± 18%	Explore
retinal cone cell	3 studies	54% ± 18%	Explore
Mueller cell	3 studies	31% ± 7%	Explore
myoepithelial cell	3 studies	35% ± 13%	Explore
goblet cell	3 studies	28% ± 17%	Explore
glial cell	3 studies	37% ± 25%	Explore
mononuclear phagocyte	3 studies	33% ± 12%	Explore
progenitor cell of mammary luminal epithelium	3 studies	26% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	8 studies	34% ± 14%	Explore
intestine	6 studies	34% ± 16%	Explore
kidney	5 studies	26% ± 13%	Explore
uterus	4 studies	40% ± 5%	Explore
breast	4 studies	24% ± 4%	Explore
bone marrow	3 studies	18% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	5762.08	653 / 653	100%	205.08	604 / 605
ovary	100%	5275.39	180 / 180	100%	178.36	429 / 430
prostate	100%	5391.03	245 / 245	99%	145.50	498 / 502
breast	100%	6679.76	459 / 459	99%	151.26	1107 / 1118
kidney	100%	4278.17	89 / 89	98%	95.26	879 / 901
intestine	100%	4695.57	966 / 966	97%	111.69	509 / 527
uterus	100%	8596.16	170 / 170	95%	134.03	438 / 459
lung	100%	5106.43	577 / 578	92%	72.82	1067 / 1155
skin	97%	3753.20	1754 / 1809	95%	75.03	449 / 472
brain	92%	2269.51	2438 / 2642	100%	133.80	702 / 705
bladder	100%	4981.90	21 / 21	90%	85.31	452 / 504
stomach	90%	2388.81	322 / 359	95%	101.56	272 / 286
esophagus	100%	3917.09	1442 / 1445	80%	46.47	147 / 183
liver	88%	1291.13	198 / 226	92%	87.90	373 / 406
adrenal gland	88%	1321.47	228 / 258	74%	42.44	171 / 230
pancreas	39%	519.67	129 / 328	97%	113.68	173 / 178
adipose	100%	7060.88	1204 / 1204	0%	0	0 / 0
blood vessel	100%	6947.61	1335 / 1335	0%	0	0 / 0
spleen	100%	4031.78	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	80.66	1 / 1
heart	99%	3056.46	849 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	43.04	28 / 29
tonsil	0%	0	0 / 0	96%	49.41	43 / 45
peripheral blood	84%	4170.30	780 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	75%	38.61	60 / 80
muscle	23%	291.44	184 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000052	Biological process	citrulline metabolic process
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0045429	Biological process	positive regulation of nitric oxide biosynthetic process
GO_0070062	Cellular component	extracellular exosome
GO_0005739	Cellular component	mitochondrion
GO_0016403	Molecular function	dimethylargininase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	DDAH2
Protein name	N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 Dimethylarginine dimethylaminohydrolase 2 Putative hydrolase DDAH2 (EC 3.-.-.-) (DDAHII) (Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2) (DDAH-2) (Inactive dimethylarginine dimethylaminohydrolase 2) (Protein G6a) (S-phase protein)
Synonyms	G6A DDAH NG30
Description	FUNCTION: Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS . In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (By similarity). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS . .
Accessions	ENST00000434279.1 ENST00000413532.5 ENST00000436437 O95865 ENST00000417916.5 ENST00000400062.5 ENST00000375789.7 ENST00000383409.6 ENST00000450563.5 ENST00000444060.1 ENST00000411456.6 ENST00000436457.5 ENST00000439767.5 ENST00000444893.5 ENST00000427351.1 ENST00000413343.5 Q5SRR8 ENST00000443533.5 ENST00000417274.1 ENST00000426149.5 A0A140T971 ENST00000430482.5 ENST00000444699.5 ENST00000455919.5 Q5SSV3 ENST00000375792.7 ENST00000449216.5 ENST00000434464.6 ENST00000375787.6 ENST00000447101.6 ENST00000457271.5 ENST00000446426.5 ENST00000424790.5 ENST00000437288.5 ENST00000436437.2 ENST00000400063.7 ENST00000413287.5 ENST00000416410 ENST00000437358.1 H0Y7N1 ENST00000441011.5 ENST00000454138.6 ENST00000434107.1 ENST00000437889.6 ENST00000416410.6 ENST00000413655.5 ENST00000427126.5 ENST00000414455.5 ENST00000451411.5

DDAH2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review