SNCA | OmnibusX

Name	Number of supported studies	Average coverage
erythrocyte	15 studies	60% ± 19%	Explore
microglial cell	13 studies	31% ± 10%	Explore
glutamatergic neuron	12 studies	56% ± 22%	Explore
oligodendrocyte	12 studies	29% ± 12%	Explore
endothelial cell of lymphatic vessel	12 studies	28% ± 11%	Explore
platelet	9 studies	47% ± 15%	Explore
neuron	8 studies	32% ± 11%	Explore
GABAergic neuron	8 studies	25% ± 10%	Explore
oligodendrocyte precursor cell	8 studies	27% ± 11%	Explore
basal cell	7 studies	23% ± 7%	Explore
macrophage	7 studies	32% ± 9%	Explore
retinal ganglion cell	6 studies	70% ± 26%	Explore
megakaryocyte	5 studies	67% ± 25%	Explore
endothelial cell	5 studies	38% ± 12%	Explore
mesothelial cell	5 studies	33% ± 13%	Explore
melanocyte	5 studies	51% ± 15%	Explore
podocyte	4 studies	40% ± 9%	Explore
erythroblast	4 studies	60% ± 34%	Explore
glial cell	4 studies	27% ± 10%	Explore
granule cell	4 studies	39% ± 9%	Explore
GABAergic amacrine cell	4 studies	31% ± 10%	Explore
fibroblast	4 studies	25% ± 7%	Explore
amacrine cell	4 studies	36% ± 15%	Explore
myeloid cell	4 studies	21% ± 3%	Explore
conventional dendritic cell	3 studies	23% ± 1%	Explore
retinal pigment epithelial cell	3 studies	34% ± 16%	Explore
Schwann cell	3 studies	37% ± 14%	Explore
interneuron	3 studies	29% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	35% ± 18%	Explore
eye	5 studies	20% ± 3%	Explore
liver	3 studies	44% ± 33%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	6371.13	2625 / 2642	91%	14.67	641 / 705
prostate	64%	608.84	157 / 245	77%	5.03	385 / 502
skin	38%	293.51	682 / 1809	97%	44.82	458 / 472
uterus	88%	1425.24	150 / 170	29%	1.87	134 / 459
ovary	87%	1008.02	157 / 180	20%	0.77	84 / 430
eye	0%	0	0 / 0	86%	13.81	69 / 80
lung	52%	431.11	298 / 578	32%	1.92	366 / 1155
peripheral blood	78%	4096.06	729 / 929	0%	0	0 / 0
adrenal gland	3%	27.66	8 / 258	61%	6.54	141 / 230
esophagus	38%	349.47	553 / 1445	23%	1.03	42 / 183
intestine	55%	683.17	535 / 966	6%	0.30	30 / 527
kidney	26%	198.33	23 / 89	22%	1.15	199 / 901
thymus	14%	101.30	93 / 653	27%	1.16	164 / 605
tonsil	0%	0	0 / 0	36%	2.39	16 / 45
bladder	19%	121.00	4 / 21	14%	0.79	73 / 504
adipose	29%	255.80	349 / 1204	0%	0	0 / 0
spleen	29%	315.32	69 / 241	0%	0	0 / 0
pancreas	0%	0	0 / 328	27%	1.33	48 / 178
breast	12%	82.73	56 / 459	7%	0.22	80 / 1118
stomach	12%	103.73	42 / 359	6%	0.28	18 / 286
heart	9%	60.30	75 / 861	0%	0	0 / 0
blood vessel	7%	62.56	90 / 1335	0%	0	0 / 0
liver	0%	0	0 / 226	1%	0.08	5 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0031623	Biological process	receptor internalization
GO_0048488	Biological process	synaptic vesicle endocytosis
GO_0010040	Biological process	response to iron(II) ion
GO_0051585	Biological process	negative regulation of dopamine uptake involved in synaptic transmission
GO_0006638	Biological process	neutral lipid metabolic process
GO_0071872	Biological process	cellular response to epinephrine stimulus
GO_0010517	Biological process	regulation of phospholipase activity
GO_0060732	Biological process	positive regulation of inositol phosphate biosynthetic process
GO_1903426	Biological process	regulation of reactive oxygen species biosynthetic process
GO_0051262	Biological process	protein tetramerization
GO_0042416	Biological process	dopamine biosynthetic process
GO_0051402	Biological process	neuron apoptotic process
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0051621	Biological process	regulation of norepinephrine uptake
GO_0016082	Biological process	synaptic vesicle priming
GO_1903285	Biological process	positive regulation of hydrogen peroxide catabolic process
GO_0001956	Biological process	positive regulation of neurotransmitter secretion
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0045920	Biological process	negative regulation of exocytosis
GO_0035543	Biological process	positive regulation of SNARE complex assembly
GO_0014059	Biological process	regulation of dopamine secretion
GO_0006919	Biological process	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO_1904377	Biological process	positive regulation of protein localization to cell periphery
GO_0032026	Biological process	response to magnesium ion
GO_0007006	Biological process	mitochondrial membrane organization
GO_0060291	Biological process	long-term synaptic potentiation
GO_0006631	Biological process	fatty acid metabolic process
GO_0042775	Biological process	mitochondrial ATP synthesis coupled electron transport
GO_0006644	Biological process	phospholipid metabolic process
GO_0050729	Biological process	positive regulation of inflammatory response
GO_0043154	Biological process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0010642	Biological process	negative regulation of platelet-derived growth factor receptor signaling pathway
GO_0051612	Biological process	negative regulation of serotonin uptake
GO_0006469	Biological process	negative regulation of protein kinase activity
GO_0048169	Biological process	regulation of long-term neuronal synaptic plasticity
GO_0001774	Biological process	microglial cell activation
GO_0032410	Biological process	negative regulation of transporter activity
GO_1904715	Biological process	negative regulation of chaperone-mediated autophagy
GO_0060079	Biological process	excitatory postsynaptic potential
GO_0031115	Biological process	negative regulation of microtubule polymerization
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_0045807	Biological process	positive regulation of endocytosis
GO_0032769	Biological process	negative regulation of monooxygenase activity
GO_0031648	Biological process	protein destabilization
GO_0034341	Biological process	response to type II interferon
GO_0097435	Biological process	supramolecular fiber organization
GO_0034599	Biological process	cellular response to oxidative stress
GO_0007268	Biological process	chemical synaptic transmission
GO_1903421	Biological process	regulation of synaptic vesicle recycling
GO_0051281	Biological process	positive regulation of release of sequestered calcium ion into cytosol
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0050808	Biological process	synapse organization
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0045921	Biological process	positive regulation of exocytosis
GO_0050812	Biological process	regulation of acyl-CoA biosynthetic process
GO_0055074	Biological process	calcium ion homeostasis
GO_0001921	Biological process	positive regulation of receptor recycling
GO_1905606	Biological process	regulation of presynapse assembly
GO_0051622	Biological process	negative regulation of norepinephrine uptake
GO_0008344	Biological process	adult locomotory behavior
GO_0051583	Biological process	dopamine uptake involved in synaptic transmission
GO_0043030	Biological process	regulation of macrophage activation
GO_0016079	Biological process	synaptic vesicle exocytosis
GO_0014048	Biological process	regulation of glutamate secretion
GO_0070555	Biological process	response to interleukin-1
GO_1902957	Biological process	negative regulation of mitochondrial electron transport, NADH to ubiquinone
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0035493	Biological process	SNARE complex assembly
GO_1903284	Biological process	positive regulation of glutathione peroxidase activity
GO_1990000	Biological process	amyloid fibril formation
GO_0071280	Biological process	cellular response to copper ion
GO_0070495	Biological process	negative regulation of thrombin-activated receptor signaling pathway
GO_0040012	Biological process	regulation of locomotion
GO_0071902	Biological process	positive regulation of protein serine/threonine kinase activity
GO_0022898	Biological process	regulation of transmembrane transporter activity
GO_0032496	Biological process	response to lipopolysaccharide
GO_0048489	Biological process	synaptic vesicle transport
GO_0099512	Cellular component	supramolecular fiber
GO_0043679	Cellular component	axon terminus
GO_0098794	Cellular component	postsynapse
GO_0043025	Cellular component	neuronal cell body
GO_0005634	Cellular component	nucleus
GO_0005576	Cellular component	extracellular region
GO_0015629	Cellular component	actin cytoskeleton
GO_0005615	Cellular component	extracellular space
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0005764	Cellular component	lysosome
GO_0032991	Cellular component	protein-containing complex
GO_0016234	Cellular component	inclusion body
GO_0005737	Cellular component	cytoplasm
GO_0030424	Cellular component	axon
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0030672	Cellular component	synaptic vesicle membrane
GO_0031092	Cellular component	platelet alpha granule membrane
GO_0005829	Cellular component	cytosol
GO_0005938	Cellular component	cell cortex
GO_0030426	Cellular component	growth cone
GO_0004860	Molecular function	protein kinase inhibitor activity
GO_0008198	Molecular function	ferrous iron binding
GO_0042802	Molecular function	identical protein binding
GO_0008270	Molecular function	zinc ion binding
GO_0048156	Molecular function	tau protein binding
GO_0005509	Molecular function	calcium ion binding
GO_0019894	Molecular function	kinesin binding
GO_0060090	Molecular function	molecular adaptor activity
GO_0042393	Molecular function	histone binding
GO_0060961	Molecular function	phospholipase D inhibitor activity
GO_0016491	Molecular function	oxidoreductase activity
GO_0030544	Molecular function	Hsp70 protein binding
GO_0003779	Molecular function	actin binding
GO_0008289	Molecular function	lipid binding
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_0000287	Molecular function	magnesium ion binding
GO_0005504	Molecular function	fatty acid binding
GO_0005507	Molecular function	copper ion binding
GO_0005515	Molecular function	protein binding
GO_0043027	Molecular function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO_0005543	Molecular function	phospholipid binding
GO_0000149	Molecular function	SNARE binding
GO_0043014	Molecular function	alpha-tubulin binding
GO_0070840	Molecular function	dynein complex binding
GO_1903136	Molecular function	cuprous ion binding
GO_0051219	Molecular function	phosphoprotein binding

IV. Literature review

[source]

Gene name	SNCA
Protein name	Alpha-synuclein Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP) Synuclein alpha
Synonyms	NACP PARK1 hCG_1777783
Description	FUNCTION: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release . Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores . Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis . Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 . This chaperone activity is important to sustain normal SNARE-complex assembly during aging . Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity . .
Accessions	ENST00000674129.1 ENST00000506244.5 [P37840-1] H6UYS0 ENST00000345009.8 [P37840-2] ENST00000394986.5 [P37840-1] ENST00000506691.1 ENST00000508895.5 [P37840-1] E7EPV7 H6UYS5 P37840 ENST00000505199.5 [P37840-3] ENST00000336904.7 [P37840-1] ENST00000611107.1 D6RA31 ENST00000394989.6 [P37840-3] ENST00000673718.1 [P37840-1] ENST00000618500.4 [P37840-3] ENST00000420646.6 [P37840-2] A0A669KB41 H6UYS7 ENST00000394991.8 [P37840-1] ENST00000673902.1 ENST00000502987.5 Q4W5L2 A0A669KBH5

SNCA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review