PRAMEF6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PRAMEF6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PRAMEF6 at tissue level.

III. Associated gene sets

GO_0045596Biological processnegative regulation of cell differentiation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0016567Biological processprotein ubiquitination
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0031462Cellular componentCul2-RING ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity

IV. Literature review

[source]
Gene namePRAMEF6
Protein namePRAME family member 6
Synonyms
DescriptionFUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation . The CRL2(PRAMEF6) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding . .

AccessionsENST00000376189.5
ENST00000632388.1
ENST00000415464.6
ENST00000632295.1
Q5VXH4