NUPR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0062099Biological processnegative regulation of programmed necrotic cell death
GO_0008285Biological processnegative regulation of cell population proliferation
GO_1901800Biological processpositive regulation of proteasomal protein catabolic process
GO_0045786Biological processnegative regulation of cell cycle
GO_0048147Biological processnegative regulation of fibroblast proliferation
GO_1905897Biological processregulation of response to endoplasmic reticulum stress
GO_1904691Biological processnegative regulation of type B pancreatic cell proliferation
GO_2001244Biological processpositive regulation of intrinsic apoptotic signaling pathway
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0002526Biological processacute inflammatory response
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0031401Biological processpositive regulation of protein modification process
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0065003Biological processprotein-containing complex assembly
GO_0045820Biological processnegative regulation of glycolytic process
GO_2000271Biological processpositive regulation of fibroblast apoptotic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0010506Biological processregulation of autophagy
GO_0048144Biological processfibroblast proliferation
GO_1904036Biological processnegative regulation of epithelial cell apoptotic process
GO_1902902Biological processnegative regulation of autophagosome assembly
GO_0010507Biological processnegative regulation of autophagy
GO_0008584Biological processmale gonad development
GO_0150078Biological processpositive regulation of neuroinflammatory response
GO_0010667Biological processnegative regulation of cardiac muscle cell apoptotic process
GO_0035914Biological processskeletal muscle cell differentiation
GO_0009636Biological processresponse to toxic substance
GO_1903862Biological processpositive regulation of oxidative phosphorylation
GO_2000194Biological processregulation of female gonad development
GO_0044346Biological processfibroblast apoptotic process
GO_0045787Biological processpositive regulation of cell cycle
GO_0032993Cellular componentprotein-DNA complex
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0045171Cellular componentintercellular bridge
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0010698Molecular functionacetyltransferase activator activity
GO_0003677Molecular functionDNA binding
GO_0003682Molecular functionchromatin binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNUPR1
Protein nameNuclear protein 1 (Candidate of metastasis 1) (Protein p8)
Nuclear protein 1, transcriptional regulator
SynonymsCOM1
DescriptionFUNCTION: Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in regulation of many process namely cell-cycle, apoptosis, autophagy and DNA repair responses . Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A . Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation . Negatively regulates apoptosis through interaction with PTMA . Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter . Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) . Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 . Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation . Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion . Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity). .

AccessionsENST00000567646.1
H3BS92
ENST00000395641.2 [O60356-2]
O60356
ENST00000324873.8 [O60356-1]