UFM1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	25 studies	24% ± 9%	Explore
natural killer cell	22 studies	21% ± 4%	Explore
fibroblast	22 studies	27% ± 14%	Explore
B cell	20 studies	22% ± 6%	Explore
macrophage	20 studies	22% ± 7%	Explore
CD8-positive, alpha-beta T cell	19 studies	20% ± 3%	Explore
naive B cell	16 studies	22% ± 5%	Explore
CD4-positive, alpha-beta T cell	16 studies	21% ± 5%	Explore
plasma cell	15 studies	41% ± 16%	Explore
memory B cell	15 studies	21% ± 5%	Explore
regulatory T cell	15 studies	19% ± 3%	Explore
ciliated cell	13 studies	35% ± 17%	Explore
non-classical monocyte	13 studies	25% ± 12%	Explore
plasmacytoid dendritic cell	13 studies	30% ± 10%	Explore
epithelial cell	13 studies	36% ± 20%	Explore
classical monocyte	12 studies	24% ± 10%	Explore
connective tissue cell	12 studies	26% ± 13%	Explore
smooth muscle cell	12 studies	21% ± 4%	Explore
pericyte	12 studies	23% ± 10%	Explore
basal cell	12 studies	29% ± 11%	Explore
gamma-delta T cell	12 studies	23% ± 8%	Explore
plasmablast	11 studies	42% ± 20%	Explore
mature NK T cell	11 studies	20% ± 4%	Explore
mast cell	10 studies	24% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	20% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	22% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	22% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	24% ± 4%	Explore
T cell	9 studies	19% ± 3%	Explore
conventional dendritic cell	9 studies	26% ± 13%	Explore
mucosal invariant T cell	9 studies	26% ± 5%	Explore
endothelial cell of vascular tree	9 studies	21% ± 5%	Explore
monocyte	8 studies	21% ± 5%	Explore
abnormal cell	8 studies	22% ± 6%	Explore
secretory cell	8 studies	27% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	22% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	23% ± 6%	Explore
capillary endothelial cell	7 studies	19% ± 2%	Explore
myofibroblast cell	7 studies	20% ± 4%	Explore
IgA plasma cell	7 studies	27% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	25% ± 5%	Explore
endothelial cell of lymphatic vessel	6 studies	24% ± 5%	Explore
type I pneumocyte	6 studies	25% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	19% ± 2%	Explore
IgG plasma cell	6 studies	26% ± 6%	Explore
innate lymphoid cell	6 studies	21% ± 4%	Explore
type II pneumocyte	6 studies	23% ± 15%	Explore
T follicular helper cell	6 studies	22% ± 4%	Explore
vein endothelial cell	6 studies	19% ± 6%	Explore
oligodendrocyte	6 studies	21% ± 5%	Explore
goblet cell	6 studies	28% ± 11%	Explore
hematopoietic precursor cell	5 studies	24% ± 11%	Explore
glutamatergic neuron	5 studies	34% ± 14%	Explore
pancreatic A cell	4 studies	33% ± 10%	Explore
leukocyte	4 studies	23% ± 2%	Explore
mononuclear phagocyte	4 studies	25% ± 9%	Explore
exhausted T cell	4 studies	24% ± 5%	Explore
endothelial cell of artery	4 studies	18% ± 3%	Explore
precursor B cell	4 studies	23% ± 4%	Explore
myeloid cell	4 studies	32% ± 14%	Explore
club cell	4 studies	27% ± 8%	Explore
immature B cell	4 studies	23% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	24% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	24% ± 4%	Explore
dendritic cell	4 studies	37% ± 18%	Explore
respiratory goblet cell	3 studies	24% ± 12%	Explore
type B pancreatic cell	3 studies	41% ± 7%	Explore
glomerular endothelial cell	3 studies	26% ± 4%	Explore
epithelial cell of proximal tubule	3 studies	18% ± 1%	Explore
neuron	3 studies	31% ± 13%	Explore
lymphocyte	3 studies	26% ± 13%	Explore
pro-B cell	3 studies	22% ± 1%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	18% ± 2%	Explore
granulocyte	3 studies	21% ± 4%	Explore
luminal cell of prostate epithelium	3 studies	27% ± 8%	Explore
muscle cell	3 studies	23% ± 6%	Explore
GABAergic neuron	3 studies	38% ± 2%	Explore
pancreatic ductal cell	3 studies	43% ± 14%	Explore
granulocyte monocyte progenitor cell	3 studies	19% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	29% ± 9%	Explore
transit amplifying cell	3 studies	21% ± 6%	Explore
interneuron	3 studies	31% ± 15%	Explore
T-helper 1 cell	3 studies	23% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	20% ± 3%	Explore
double negative thymocyte	3 studies	29% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	24% ± 7%	Explore
lung	11 studies	26% ± 11%	Explore
kidney	5 studies	18% ± 1%	Explore
uterus	5 studies	27% ± 14%	Explore
brain	5 studies	31% ± 7%	Explore
intestine	5 studies	23% ± 7%	Explore
pancreas	4 studies	35% ± 13%	Explore
bone marrow	4 studies	19% ± 3%	Explore
lymph node	4 studies	17% ± 2%	Explore
breast	4 studies	18% ± 3%	Explore
placenta	3 studies	27% ± 8%	Explore
eye	3 studies	20% ± 2%	Explore
prostate	3 studies	25% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	4386.99	459 / 459	100%	65.12	1118 / 1118
esophagus	100%	3266.95	1445 / 1445	100%	49.68	183 / 183
lung	100%	4765.29	578 / 578	100%	53.94	1155 / 1155
pancreas	100%	4577.34	328 / 328	100%	56.55	178 / 178
prostate	100%	5529.56	245 / 245	100%	64.30	502 / 502
brain	100%	4110.13	2641 / 2642	100%	59.67	705 / 705
ovary	100%	5416.18	180 / 180	100%	37.02	429 / 430
kidney	100%	4319.69	89 / 89	100%	60.15	898 / 901
uterus	100%	4927.45	170 / 170	100%	49.79	457 / 459
bladder	100%	3838.19	21 / 21	99%	51.77	501 / 504
thymus	100%	4514.22	653 / 653	99%	59.33	601 / 605
stomach	100%	3663.07	359 / 359	99%	58.92	284 / 286
intestine	100%	4011.10	966 / 966	98%	64.24	518 / 527
adrenal gland	100%	3899.80	258 / 258	98%	54.42	226 / 230
liver	100%	3044.21	226 / 226	97%	32.30	395 / 406
skin	100%	4770.54	1808 / 1809	95%	55.45	447 / 472
adipose	100%	4540.44	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4148.10	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	37.73	29 / 29
spleen	100%	4081.08	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	35.20	45 / 45
ureter	0%	0	0 / 0	100%	14.38	1 / 1
muscle	99%	1793.87	797 / 803	0%	0	0 / 0
heart	99%	2354.47	850 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	73%	17.74	58 / 80
peripheral blood	48%	1601.31	444 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007420	Biological process	brain development
GO_0061709	Biological process	reticulophagy
GO_0042308	Biological process	negative regulation of protein import into nucleus
GO_0043066	Biological process	negative regulation of apoptotic process
GO_1990592	Biological process	protein K69-linked ufmylation
GO_0071569	Biological process	protein ufmylation
GO_0034976	Biological process	response to endoplasmic reticulum stress
GO_0033146	Biological process	regulation of intracellular estrogen receptor signaling pathway
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	UFM1
Protein name	Ubiquitin-fold modifier 1
Synonyms	BM-002 C13orf20
Description	FUNCTION: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer . The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 . Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress . Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription . .
Accessions	P61960 ENST00000437952.1 ENST00000239878.9 [P61960-1] H0Y614 ENST00000379649.5 [P61960-2]

UFM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review