IGF1R report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0071260Biological processcellular response to mechanical stimulus
GO_0048009Biological processinsulin-like growth factor receptor signaling pathway
GO_0007275Biological processmulticellular organism development
GO_0071392Biological processcellular response to estradiol stimulus
GO_0006955Biological processimmune response
GO_0043066Biological processnegative regulation of apoptotic process
GO_0035094Biological processresponse to nicotine
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0021549Biological processcerebellum development
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0032467Biological processpositive regulation of cytokinesis
GO_0043243Biological processpositive regulation of protein-containing complex disassembly
GO_0034224Biological processcellular response to zinc ion starvation
GO_1904385Biological processcellular response to angiotensin
GO_0046328Biological processregulation of JNK cascade
GO_0071333Biological processcellular response to glucose stimulus
GO_1990314Biological processcellular response to insulin-like growth factor stimulus
GO_0071549Biological processcellular response to dexamethasone stimulus
GO_0007165Biological processsignal transduction
GO_0003230Biological processcardiac atrium development
GO_0033197Biological processresponse to vitamin E
GO_1904045Biological processcellular response to aldosterone
GO_0048680Biological processpositive regulation of axon regeneration
GO_0097062Biological processdendritic spine maintenance
GO_0046777Biological processprotein autophosphorylation
GO_1902065Biological processresponse to L-glutamate
GO_1904193Biological processnegative regulation of cholangiocyte apoptotic process
GO_0044849Biological processestrous cycle
GO_0021766Biological processhippocampus development
GO_0033690Biological processpositive regulation of osteoblast proliferation
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0043279Biological processresponse to alkaloid
GO_0071394Biological processcellular response to testosterone stimulus
GO_0045471Biological processresponse to ethanol
GO_1903944Biological processnegative regulation of hepatocyte apoptotic process
GO_0097242Biological processamyloid-beta clearance
GO_0007409Biological processaxonogenesis
GO_0038083Biological processpeptidyl-tyrosine autophosphorylation
GO_0033674Biological processpositive regulation of kinase activity
GO_0008286Biological processinsulin receptor signaling pathway
GO_0045056Biological processtranscytosis
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0051054Biological processpositive regulation of DNA metabolic process
GO_1904646Biological processcellular response to amyloid-beta
GO_0071393Biological processcellular response to progesterone stimulus
GO_0030010Biological processestablishment of cell polarity
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0030335Biological processpositive regulation of cell migration
GO_0043409Biological processnegative regulation of MAPK cascade
GO_0090031Biological processpositive regulation of steroid hormone biosynthetic process
GO_0090398Biological processcellular senescence
GO_0010656Biological processnegative regulation of muscle cell apoptotic process
GO_0005899Cellular componentinsulin receptor complex
GO_0043025Cellular componentneuronal cell body
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_1902911Cellular componentprotein kinase complex
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0030315Cellular componentT-tubule
GO_0035867Cellular componentalphav-beta3 integrin-IGF-1-IGF1R complex
GO_0030424Cellular componentaxon
GO_0005901Cellular componentcaveola
GO_0043548Molecular functionphosphatidylinositol 3-kinase binding
GO_0005009Molecular functioninsulin receptor activity
GO_0001965Molecular functionG-protein alpha-subunit binding
GO_0042802Molecular functionidentical protein binding
GO_0005524Molecular functionATP binding
GO_0005520Molecular functioninsulin-like growth factor binding
GO_0043559Molecular functioninsulin binding
GO_0005010Molecular functioninsulin-like growth factor receptor activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0031994Molecular functioninsulin-like growth factor I binding
GO_0005515Molecular functionprotein binding
GO_0005158Molecular functioninsulin receptor binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0043560Molecular functioninsulin receptor substrate binding
GO_0140318Molecular functionprotein transporter activity

IV. Literature review

[source]
Gene nameIGF1R
Protein nameInsulin like growth factor 1 receptor
IGF1R protein
receptor protein-tyrosine kinase (EC 2.7.10.1)
Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Tyrosine-protein kinase receptor (EC 2.7.10.1)
Synonyms
DescriptionFUNCTION: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.; FUNCTION: When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

AccessionsQ3B833
ENST00000558355.1
C9J5X1
P08069
ENST00000558898.1
H0YMJ5
ENST00000649865.1
ENST00000560144.1
ENST00000650285.1
H0YNR0
H3BSZ8