Insufficient scRNA-seq data for expression of ERFE at single-cell level.
Insufficient scRNA-seq data for expression of ERFE at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 97% | 465.47 | 635 / 653 | 80% | 39.95 | 486 / 605 |
kidney | 83% | 332.82 | 74 / 89 | 33% | 9.39 | 296 / 901 |
brain | 65% | 240.93 | 1707 / 2642 | 46% | 2.78 | 325 / 705 |
lung | 61% | 77.34 | 350 / 578 | 48% | 4.18 | 558 / 1155 |
muscle | 99% | 1051.28 | 794 / 803 | 0% | 0 | 0 / 0 |
uterus | 37% | 31.24 | 63 / 170 | 51% | 6.03 | 234 / 459 |
blood vessel | 88% | 146.78 | 1173 / 1335 | 0% | 0 | 0 / 0 |
esophagus | 20% | 16.44 | 293 / 1445 | 60% | 3.22 | 110 / 183 |
intestine | 44% | 39.23 | 422 / 966 | 29% | 1.93 | 155 / 527 |
ovary | 4% | 2.71 | 7 / 180 | 67% | 10.67 | 289 / 430 |
bladder | 48% | 79.81 | 10 / 21 | 22% | 1.44 | 111 / 504 |
eye | 0% | 0 | 0 / 0 | 64% | 4.54 | 51 / 80 |
skin | 29% | 52.84 | 531 / 1809 | 30% | 2.26 | 143 / 472 |
peripheral blood | 53% | 192.11 | 496 / 929 | 0% | 0 | 0 / 0 |
adipose | 51% | 52.86 | 620 / 1204 | 0% | 0 | 0 / 0 |
spleen | 48% | 66.97 | 115 / 241 | 0% | 0 | 0 / 0 |
prostate | 44% | 63.62 | 109 / 245 | 1% | 0.04 | 7 / 502 |
stomach | 16% | 13.53 | 56 / 359 | 25% | 1.36 | 71 / 286 |
tonsil | 0% | 0 | 0 / 0 | 38% | 1.95 | 17 / 45 |
heart | 36% | 42.98 | 306 / 861 | 0% | 0 | 0 / 0 |
breast | 23% | 23.53 | 104 / 459 | 8% | 0.31 | 87 / 1118 |
pancreas | 13% | 9.22 | 43 / 328 | 16% | 0.64 | 28 / 178 |
liver | 10% | 18.45 | 23 / 226 | 15% | 0.81 | 62 / 406 |
lymph node | 0% | 0 | 0 / 0 | 7% | 0.18 | 2 / 29 |
adrenal gland | 2% | 2.98 | 6 / 258 | 3% | 0.28 | 7 / 230 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0010507 | Biological process | negative regulation of autophagy |
GO_0007165 | Biological process | signal transduction |
GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0015908 | Biological process | fatty acid transport |
GO_0045671 | Biological process | negative regulation of osteoclast differentiation |
GO_2000193 | Biological process | positive regulation of fatty acid transport |
GO_0019217 | Biological process | regulation of fatty acid metabolic process |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_0046326 | Biological process | positive regulation of glucose import |
GO_0006879 | Biological process | intracellular iron ion homeostasis |
GO_0045721 | Biological process | negative regulation of gluconeogenesis |
GO_0045668 | Biological process | negative regulation of osteoblast differentiation |
GO_0051649 | Biological process | establishment of localization in cell |
GO_0046628 | Biological process | positive regulation of insulin receptor signaling pathway |
GO_0005615 | Cellular component | extracellular space |
GO_0005576 | Cellular component | extracellular region |
GO_0005179 | Molecular function | hormone activity |
GO_0042802 | Molecular function | identical protein binding |
Gene name | ERFE |
Protein name | Erythroferrone (Complement C1q tumor necrosis factor-related protein 15) (Myonectin) Erythroferrone |
Synonyms | FAM132B C1QTNF15 CTRP15 |
Description | FUNCTION: Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores . Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (By similarity). Inhibits apoptosis and inflammatory response in cardiomyocytes via promotion of sphingosine-1-phosphate (S1P) and cAMP-dependent activation of AKT signaling (By similarity). Inhibits autophagy induced by nutrient deficiency in hepatocytes via promoting the phosphorylation of IRS1, AKT, and MTOR, and thereby subsequent activation of the AKT-MTOR signaling pathway (By similarity). Negatively regulates the differentiation of osteoblasts, potentially via sequestering BMP2, and thereby inhibits the activation of SMAD signaling (By similarity). The reduction in BMP2 signaling in osteoblasts also results in an increase in expression of the osteoclastogenesis-promoting factors TNFSF11/RANKL and SOST, thereby indirectly promotes bone resorption (By similarity). . |
Accessions | ENST00000357303.3 H0Y2X4 ENST00000344233.6 ENST00000546354.6 Q4G0M1 H7BY19 |