ERFE report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ERFE at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ERFE at tissue level.

III. Associated gene sets

GO_0010507Biological processnegative regulation of autophagy
GO_0007165Biological processsignal transduction
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0015908Biological processfatty acid transport
GO_0045671Biological processnegative regulation of osteoclast differentiation
GO_2000193Biological processpositive regulation of fatty acid transport
GO_0019217Biological processregulation of fatty acid metabolic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0046326Biological processpositive regulation of glucose import
GO_0006879Biological processintracellular iron ion homeostasis
GO_0045721Biological processnegative regulation of gluconeogenesis
GO_0045668Biological processnegative regulation of osteoblast differentiation
GO_0051649Biological processestablishment of localization in cell
GO_0046628Biological processpositive regulation of insulin receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005179Molecular functionhormone activity
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene nameERFE
Protein nameErythroferrone (Complement C1q tumor necrosis factor-related protein 15) (Myonectin)
Erythroferrone
SynonymsFAM132B
C1QTNF15
CTRP15
DescriptionFUNCTION: Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores . Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (By similarity). Inhibits apoptosis and inflammatory response in cardiomyocytes via promotion of sphingosine-1-phosphate (S1P) and cAMP-dependent activation of AKT signaling (By similarity). Inhibits autophagy induced by nutrient deficiency in hepatocytes via promoting the phosphorylation of IRS1, AKT, and MTOR, and thereby subsequent activation of the AKT-MTOR signaling pathway (By similarity). Negatively regulates the differentiation of osteoblasts, potentially via sequestering BMP2, and thereby inhibits the activation of SMAD signaling (By similarity). The reduction in BMP2 signaling in osteoblasts also results in an increase in expression of the osteoclastogenesis-promoting factors TNFSF11/RANKL and SOST, thereby indirectly promotes bone resorption (By similarity). .

AccessionsENST00000357303.3
H0Y2X4
ENST00000344233.6
ENST00000546354.6
Q4G0M1
H7BY19