MNAT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0006289Biological processnucleotide-excision repair
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0021591Biological processventricular system development
GO_0043066Biological processnegative regulation of apoptotic process
GO_0007512Biological processadult heart development
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0051592Biological processresponse to calcium ion
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0070985Cellular componenttranscription factor TFIIK complex
GO_0005654Cellular componentnucleoplasm
GO_0000439Cellular componenttranscription factor TFIIH core complex
GO_0000307Cellular componentcyclin-dependent protein kinase holoenzyme complex
GO_0070516Cellular componentCAK-ERCC2 complex
GO_0005675Cellular componenttranscription factor TFIIH holo complex
GO_0061575Molecular functioncyclin-dependent protein serine/threonine kinase activator activity
GO_0008270Molecular functionzinc ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMNAT1
Protein nameCDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36)
Menage a trois-like protein 1 cyclin H assembly factor isoform 2
MNAT1 component of CDK activating kinase
Menage a trois-like protein 1 cyclin H assembly factor isoform 1
SynonymsCAP35
RNF66
MAT1
DescriptionFUNCTION: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. .

AccessionsH0YJF2
H0YJ92
ENST00000261245.9 [P51948-1]
ENST00000554002.5
A0A024R688
P51948
A0A0S2Z414
ENST00000539616.6 [P51948-2]
ENST00000557134.1