Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| plasma cell | 14 studies | 49% ± 25% | |
| plasmablast | 8 studies | 66% ± 25% | |
| IgA plasma cell | 4 studies | 41% ± 22% | |
| plasmacytoid dendritic cell | 4 studies | 23% ± 8% | |
| fibroblast | 3 studies | 22% ± 4% |
Insufficient scRNA-seq data for expression of TXNDC5 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 7481.80 | 1444 / 1445 | 87% | 2.52 | 159 / 183 |
| ovary | 100% | 12722.83 | 180 / 180 | 86% | 2.90 | 368 / 430 |
| stomach | 100% | 11504.53 | 359 / 359 | 69% | 3.09 | 198 / 286 |
| intestine | 100% | 14037.63 | 966 / 966 | 50% | 2.13 | 264 / 527 |
| lung | 100% | 12958.06 | 578 / 578 | 21% | 0.57 | 240 / 1155 |
| bladder | 100% | 10002.48 | 21 / 21 | 18% | 0.73 | 91 / 504 |
| skin | 98% | 13226.64 | 1774 / 1809 | 11% | 0.17 | 53 / 472 |
| breast | 100% | 12388.87 | 459 / 459 | 3% | 0.06 | 39 / 1118 |
| pancreas | 100% | 13135.57 | 328 / 328 | 3% | 0.05 | 6 / 178 |
| kidney | 100% | 8078.11 | 89 / 89 | 3% | 0.04 | 23 / 901 |
| uterus | 100% | 10951.81 | 170 / 170 | 2% | 0.04 | 8 / 459 |
| thymus | 100% | 9093.43 | 652 / 653 | 1% | 0.02 | 8 / 605 |
| prostate | 100% | 8555.44 | 244 / 245 | 1% | 0.02 | 7 / 502 |
| liver | 100% | 13411.49 | 226 / 226 | 0% | 0.01 | 2 / 406 |
| adipose | 100% | 13228.48 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 100% | 9511.32 | 258 / 258 | 0% | 0 | 0 / 230 |
| spleen | 100% | 37613.74 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 11995.29 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| heart | 96% | 6082.70 | 826 / 861 | 0% | 0 | 0 / 0 |
| muscle | 56% | 1646.72 | 447 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 56% | 8757.43 | 516 / 929 | 0% | 0 | 0 / 0 |
| brain | 51% | 1434.76 | 1354 / 2642 | 1% | 0.02 | 5 / 705 |
| lymph node | 0% | 0 | 0 / 0 | 10% | 0.13 | 3 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.03 | 1 / 45 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.01 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006457 | Biological process | protein folding |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0035578 | Cellular component | azurophil granule lumen |
| GO_0043202 | Cellular component | lysosomal lumen |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005576 | Cellular component | extracellular region |
| GO_0015035 | Molecular function | protein-disulfide reductase activity |
| GO_0003756 | Molecular function | protein disulfide isomerase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TXNDC5 |
| Protein name | protein disulfide-isomerase (EC 5.3.4.1) Thioredoxin domain-containing protein 5 (EC 1.8.4.-) (EC 5.3.4.1) (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46) |
| Synonyms | UNQ364/PRO700 TLP46 |
| Description | FUNCTION: Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds. . |
| Accessions | ENST00000473453.2 [Q8NBS9-2] Q8NBS9 Q86UY0 ENST00000379757.9 [Q8NBS9-1] |
