PRAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_2001140Biological processpositive regulation of phospholipid transport
GO_0043066Biological processnegative regulation of apoptotic process
GO_0071481Biological processcellular response to X-ray
GO_1905885Biological processpositive regulation of triglyceride transport
GO_1902426Biological processdeactivation of mitotic spindle assembly checkpoint
GO_0006977Biological processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO_1904731Biological processpositive regulation of intestinal lipid absorption
GO_0005783Cellular componentendoplasmic reticulum
GO_0005576Cellular componentextracellular region
GO_0017129Molecular functiontriglyceride binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRAP1
Protein nameProline-rich acidic protein 1 (Epididymis tissue protein Li 178) (Uterine-specific proline-rich acidic protein)
SynonymsUNQ608/PRO1195
UPA
DescriptionFUNCTION: Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion (By similarity). Protects the gastrointestinal epithelium from irradiation-induced apoptosis (By similarity). May play an important role in maintaining normal growth homeostasis in epithelial cells . Involved in p53/TP53-dependent cell survival after DNA damage . May down-regulate the expression of MAD1L1 and exert a suppressive role in mitotic spindle assembly checkpoint in hepatocellular carcinomas . .

AccessionsENST00000463201.2 [Q96NZ9-4]
Q96NZ9
ENST00000433452.6 [Q96NZ9-1]