PDPN | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell of lymphatic vessel	21 studies	49% ± 20%	Explore
fibroblast	19 studies	33% ± 18%	Explore
mesothelial cell	11 studies	41% ± 15%	Explore
type I pneumocyte	7 studies	37% ± 18%	Explore
adventitial cell	5 studies	21% ± 4%	Explore
astrocyte	4 studies	30% ± 9%	Explore
basal cell	3 studies	30% ± 9%	Explore
microglial cell	3 studies	21% ± 7%	Explore
Mueller cell	3 studies	27% ± 5%	Explore
chondrocyte	3 studies	34% ± 7%	Explore
oligodendrocyte precursor cell	3 studies	26% ± 1%	Explore
connective tissue cell	3 studies	28% ± 17%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PDPN at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	3317.72	576 / 578	88%	52.37	1017 / 1155
esophagus	97%	1727.72	1405 / 1445	87%	57.28	159 / 183
stomach	96%	2398.65	345 / 359	87%	27.71	250 / 286
intestine	97%	1763.84	938 / 966	84%	26.69	443 / 527
bladder	100%	4288.81	21 / 21	77%	36.48	388 / 504
breast	94%	2418.07	432 / 459	81%	22.87	906 / 1118
ovary	100%	3187.32	180 / 180	67%	21.45	287 / 430
uterus	99%	2645.72	169 / 170	67%	39.47	308 / 459
prostate	99%	1941.53	242 / 245	62%	10.07	312 / 502
brain	81%	821.00	2139 / 2642	62%	103.60	439 / 705
pancreas	39%	233.54	127 / 328	89%	43.51	159 / 178
skin	92%	1638.88	1658 / 1809	35%	13.81	163 / 472
muscle	99%	1839.92	798 / 803	0%	0	0 / 0
thymus	79%	701.43	518 / 653	18%	4.01	110 / 605
tonsil	0%	0	0 / 0	93%	84.66	42 / 45
adipose	91%	3693.93	1094 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	86%	33.82	25 / 29
heart	85%	1012.62	731 / 861	0%	0	0 / 0
blood vessel	58%	735.28	774 / 1335	0%	0	0 / 0
kidney	44%	280.62	39 / 89	9%	2.96	84 / 901
adrenal gland	34%	222.49	88 / 258	5%	2.01	11 / 230
eye	0%	0	0 / 0	11%	2.28	9 / 80
liver	1%	3.69	2 / 226	5%	0.91	19 / 406
peripheral blood	1%	13.90	12 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0030324	Biological process	lung development
GO_0090091	Biological process	positive regulation of extracellular matrix disassembly
GO_0060838	Biological process	lymphatic endothelial cell fate commitment
GO_1904328	Biological process	regulation of myofibroblast contraction
GO_0048535	Biological process	lymph node development
GO_0007165	Biological process	signal transduction
GO_0001946	Biological process	lymphangiogenesis
GO_0007155	Biological process	cell adhesion
GO_0030168	Biological process	platelet activation
GO_0070252	Biological process	actin-mediated cell contraction
GO_0006833	Biological process	water transport
GO_1900024	Biological process	regulation of substrate adhesion-dependent cell spreading
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0030335	Biological process	positive regulation of cell migration
GO_0044319	Biological process	wound healing, spreading of cells
GO_1901731	Biological process	positive regulation of platelet aggregation
GO_0010718	Biological process	positive regulation of epithelial to mesenchymal transition
GO_0007266	Biological process	Rho protein signal transduction
GO_0008360	Biological process	regulation of cell shape
GO_0006865	Biological process	amino acid transport
GO_2000392	Biological process	regulation of lamellipodium morphogenesis
GO_0016477	Biological process	cell migration
GO_0015884	Biological process	folic acid transport
GO_0001726	Cellular component	ruffle
GO_0032587	Cellular component	ruffle membrane
GO_0016324	Cellular component	apical plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0045121	Cellular component	membrane raft
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0031528	Cellular component	microvillus membrane
GO_0061851	Cellular component	leading edge of lamellipodium
GO_0030175	Cellular component	filopodium
GO_0031527	Cellular component	filopodium membrane
GO_0031258	Cellular component	lamellipodium membrane
GO_0005829	Cellular component	cytosol
GO_0070161	Cellular component	anchoring junction
GO_0097197	Cellular component	tetraspanin-enriched microdomain
GO_0042995	Cellular component	cell projection
GO_0030054	Cellular component	cell junction
GO_0030027	Cellular component	lamellipodium
GO_0016323	Cellular component	basolateral plasma membrane
GO_0015250	Molecular function	water channel activity
GO_0015171	Molecular function	amino acid transmembrane transporter activity
GO_0019956	Molecular function	chemokine binding
GO_0005102	Molecular function	signaling receptor binding
GO_0051087	Molecular function	protein-folding chaperone binding
GO_0008517	Molecular function	folic acid transmembrane transporter activity
GO_0005372	Molecular function	water transmembrane transporter activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PDPN
Protein name	Podoplanin Podoplanin (Aggrus) (Glycoprotein 36) (Gp36) (PA2.26 antigen) (T1-alpha) (T1A) [Cleaved into: 29kDa cytosolic podoplanin intracellular domain (PICD)]
Synonyms	PSEC0003 PSEC0025 GP36
Description	FUNCTION: Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation . Interaction with CD9, on the contrary, attenuates platelet aggregation induced by PDPN . Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness . Interaction with CD44 promotes directional cell migration in epithelial and tumor cells . In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 activation through association with unknown transmembrane proteins. Engagement of CLEC1B by PDPN promotes FRCs relaxation by blocking lateral membrane interactions leading to reduction of ERM proteins (EZR; MSN and RDX) and MYL9 activation (By similarity). Through binding with LGALS8 may participate in connection of the lymphatic endothelium to the surrounding extracellular matrix . In keratinocytes, induces changes in cell morphology showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion . Controls invadopodia stability and maturation leading to efficient degradation of the extracellular matrix (ECM) in tumor cells through modulation of RHOC activity in order to activate ROCK1/ROCK2 and LIMK1/LIMK2 and inactivation of CFL1 . Required for normal lung cell proliferation and alveolus formation at birth (By similarity). Does not function as a water channel or as a regulator of aquaporin-type water channels . Does not have any effect on folic acid or amino acid transport (By similarity). .
Accessions	ENST00000376061.8 [Q86YL7-6] ENST00000621990.5 [Q86YL7-1] ENST00000488631.1 Q86YL7 ENST00000376057.8 [Q86YL7-4] H0Y8Q3 ENST00000510906.5 ENST00000506205.1 E7ETC6 ENST00000487038.5 [Q86YL7-6] ENST00000513143.5 [Q86YL7-6] ENST00000509009.5 H0YA72 ENST00000475043.5 [Q86YL7-5] ENST00000294489.10 [Q86YL7-3] D6RH07

PDPN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review