I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell of lymphatic vessel | 18 studies | 29% ± 11% | |
| type I pneumocyte | 9 studies | 38% ± 13% | |
| astrocyte | 9 studies | 27% ± 9% | |
| ciliated cell | 4 studies | 25% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell of lymphatic vessel | 18 studies | 29% ± 11% | |
| type I pneumocyte | 9 studies | 38% ± 13% | |
| astrocyte | 9 studies | 27% ± 9% | |
| ciliated cell | 4 studies | 25% ± 7% |
Insufficient scRNA-seq data for expression of WFS1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 6760.90 | 244 / 245 | 100% | 59.57 | 500 / 502 |
| breast | 100% | 6710.01 | 459 / 459 | 97% | 67.85 | 1088 / 1118 |
| brain | 97% | 6765.05 | 2565 / 2642 | 99% | 55.53 | 700 / 705 |
| intestine | 99% | 5906.47 | 954 / 966 | 97% | 52.81 | 509 / 527 |
| ovary | 100% | 15375.62 | 180 / 180 | 95% | 35.62 | 407 / 430 |
| skin | 98% | 4076.12 | 1779 / 1809 | 96% | 39.41 | 454 / 472 |
| lung | 100% | 8418.03 | 577 / 578 | 95% | 33.68 | 1093 / 1155 |
| bladder | 100% | 10304.67 | 21 / 21 | 94% | 41.69 | 475 / 504 |
| thymus | 100% | 9537.70 | 653 / 653 | 92% | 42.56 | 555 / 605 |
| stomach | 95% | 4374.82 | 340 / 359 | 97% | 50.06 | 277 / 286 |
| adrenal gland | 99% | 3442.21 | 256 / 258 | 92% | 76.39 | 212 / 230 |
| uterus | 99% | 13088.02 | 169 / 170 | 84% | 26.77 | 387 / 459 |
| pancreas | 86% | 1821.57 | 283 / 328 | 97% | 46.43 | 173 / 178 |
| esophagus | 86% | 6415.98 | 1237 / 1445 | 95% | 37.22 | 173 / 183 |
| kidney | 97% | 2729.25 | 86 / 89 | 82% | 19.33 | 741 / 901 |
| liver | 61% | 1323.36 | 138 / 226 | 80% | 19.48 | 326 / 406 |
| adipose | 100% | 6941.68 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 11703.25 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 46.37 | 80 / 80 |
| spleen | 100% | 5355.60 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 26.86 | 1 / 1 |
| heart | 97% | 6538.04 | 839 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 80% | 14.58 | 36 / 45 |
| muscle | 74% | 1373.63 | 595 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 21% | 2.64 | 6 / 29 |
| peripheral blood | 1% | 14.03 | 9 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0055074 | Biological process | calcium ion homeostasis |
| GO_0007601 | Biological process | visual perception |
| GO_0007605 | Biological process | sensory perception of sound |
| GO_0045927 | Biological process | positive regulation of growth |
| GO_0003091 | Biological process | renal water homeostasis |
| GO_0051247 | Biological process | positive regulation of protein metabolic process |
| GO_0042593 | Biological process | glucose homeostasis |
| GO_0022417 | Biological process | protein maturation by protein folding |
| GO_0031016 | Biological process | pancreas development |
| GO_1902236 | Biological process | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| GO_0034976 | Biological process | response to endoplasmic reticulum stress |
| GO_0001822 | Biological process | kidney development |
| GO_0006983 | Biological process | ER overload response |
| GO_2000675 | Biological process | negative regulation of type B pancreatic cell apoptotic process |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0043069 | Biological process | negative regulation of programmed cell death |
| GO_1903573 | Biological process | negative regulation of response to endoplasmic reticulum stress |
| GO_0030968 | Biological process | endoplasmic reticulum unfolded protein response |
| GO_0042048 | Biological process | olfactory behavior |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0050821 | Biological process | protein stabilization |
| GO_0051928 | Biological process | positive regulation of calcium ion transport |
| GO_1903892 | Biological process | negative regulation of ATF6-mediated unfolded protein response |
| GO_0031398 | Biological process | positive regulation of protein ubiquitination |
| GO_1904294 | Biological process | positive regulation of ERAD pathway |
| GO_0043524 | Biological process | negative regulation of neuron apoptotic process |
| GO_0050877 | Biological process | nervous system process |
| GO_0036503 | Biological process | ERAD pathway |
| GO_0032469 | Biological process | endoplasmic reticulum calcium ion homeostasis |
| GO_0017148 | Biological process | negative regulation of translation |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0030672 | Cellular component | synaptic vesicle membrane |
| GO_0030425 | Cellular component | dendrite |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0030141 | Cellular component | secretory granule |
| GO_0140297 | Molecular function | DNA-binding transcription factor binding |
| GO_0070628 | Molecular function | proteasome binding |
| GO_0031625 | Molecular function | ubiquitin protein ligase binding |
| GO_0048306 | Molecular function | calcium-dependent protein binding |
| GO_0051117 | Molecular function | ATPase binding |
| GO_0005516 | Molecular function | calmodulin binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | WFS1 |
| Protein name | Wolframin Wolfram syndrome 1 isoform 1 Wolframin ER transmembrane glycoprotein Wolfram syndrome 1 isoform 2 |
| Synonyms | |
| Description | FUNCTION: Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store . Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism . . |
| Accessions | ENST00000684700.1 ENST00000226760.5 O76024 A0A804HK77 ENST00000673991.1 A0A669KB26 ENST00000674051.1 A0A669KBF0 A0A804HIL2 A0A804HIL0 ENST00000682275.1 ENST00000673642.1 ENST00000684087.1 ENST00000682059.1 ENST00000503569.5 A0A804HKM5 A0A0S2Z4V4 A0A0S2Z4V6 ENST00000684054.1 H0Y9G5 A0A669KAX3 ENST00000683395.1 ENST00000506362.2 |
