NAT8B report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NAT8B at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NAT8B at tissue level.

III. Associated gene sets

GO_0010628Biological processpositive regulation of gene expression
GO_1990000Biological processamyloid fibril formation
GO_0018003Biological processpeptidyl-lysine N6-acetylation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0050435Biological processamyloid-beta metabolic process
GO_0001702Biological processgastrulation with mouth forming second
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0005793Cellular componentendoplasmic reticulum-Golgi intermediate compartment
GO_0016020Cellular componentmembrane
GO_0008080Molecular functionN-acetyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0004468Molecular functionlysine N-acetyltransferase activity, acting on acetyl phosphate as donor

IV. Literature review

[source]
Gene nameNAT8B
Protein namePutative N-acetyltransferase 8B (EC 2.3.1.-) (Acetyltransferase 1) (ATase1) (Camello-like protein 2)
SynonymsCML2
DescriptionFUNCTION: Lysine N-acetyltransferase catalyzing peptidyl-lysine N6-acetylation of various proteins, including PROM1/CD133. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 . Acetylates and stabilizes BACE1 immature protein, leading to increased steady-state levels in neurons. By acting on BACE1 expression, may regulate amyloid beta-peptide formation . May play a role in regulation of gastrulation (By similarity). .

AccessionsQ9UHF3