BNIP3L | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	45 studies	37% ± 16%	Explore
macrophage	37 studies	37% ± 13%	Explore
pericyte	33 studies	37% ± 18%	Explore
endothelial cell	30 studies	32% ± 13%	Explore
smooth muscle cell	27 studies	28% ± 9%	Explore
classical monocyte	25 studies	42% ± 11%	Explore
mast cell	24 studies	32% ± 14%	Explore
conventional dendritic cell	24 studies	30% ± 13%	Explore
non-classical monocyte	21 studies	31% ± 11%	Explore
monocyte	20 studies	35% ± 13%	Explore
regulatory T cell	17 studies	20% ± 6%	Explore
dendritic cell	15 studies	34% ± 15%	Explore
endothelial cell of lymphatic vessel	15 studies	31% ± 9%	Explore
erythrocyte	15 studies	57% ± 22%	Explore
ciliated cell	15 studies	34% ± 18%	Explore
connective tissue cell	15 studies	39% ± 11%	Explore
astrocyte	14 studies	32% ± 12%	Explore
B cell	13 studies	23% ± 7%	Explore
myofibroblast cell	13 studies	37% ± 10%	Explore
myeloid cell	13 studies	32% ± 13%	Explore
natural killer cell	12 studies	22% ± 7%	Explore
epithelial cell	12 studies	44% ± 21%	Explore
microglial cell	12 studies	38% ± 13%	Explore
oligodendrocyte	12 studies	35% ± 14%	Explore
type II pneumocyte	11 studies	35% ± 13%	Explore
naive B cell	11 studies	21% ± 6%	Explore
oligodendrocyte precursor cell	11 studies	30% ± 14%	Explore
CD4-positive, alpha-beta T cell	10 studies	23% ± 10%	Explore
glutamatergic neuron	10 studies	47% ± 20%	Explore
basal cell	9 studies	39% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	21% ± 5%	Explore
abnormal cell	9 studies	34% ± 18%	Explore
adipocyte	9 studies	47% ± 10%	Explore
alveolar macrophage	8 studies	23% ± 6%	Explore
type I pneumocyte	8 studies	29% ± 6%	Explore
club cell	8 studies	32% ± 13%	Explore
neutrophil	8 studies	29% ± 10%	Explore
leukocyte	8 studies	26% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	20% ± 6%	Explore
epithelial cell of proximal tubule	8 studies	33% ± 12%	Explore
GABAergic neuron	8 studies	39% ± 20%	Explore
memory B cell	8 studies	17% ± 2%	Explore
endothelial cell of vascular tree	8 studies	23% ± 8%	Explore
T cell	7 studies	25% ± 8%	Explore
secretory cell	7 studies	31% ± 13%	Explore
platelet	7 studies	24% ± 5%	Explore
mononuclear phagocyte	7 studies	35% ± 12%	Explore
interneuron	7 studies	40% ± 23%	Explore
CD8-positive, alpha-beta T cell	7 studies	23% ± 10%	Explore
hematopoietic stem cell	7 studies	29% ± 7%	Explore
neuron	7 studies	40% ± 16%	Explore
endothelial cell of artery	6 studies	22% ± 3%	Explore
retinal ganglion cell	6 studies	69% ± 28%	Explore
retinal cone cell	6 studies	41% ± 18%	Explore
retinal rod cell	6 studies	29% ± 10%	Explore
Mueller cell	6 studies	53% ± 23%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	20% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	20% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	21% ± 3%	Explore
progenitor cell	5 studies	33% ± 21%	Explore
vein endothelial cell	5 studies	23% ± 8%	Explore
capillary endothelial cell	5 studies	25% ± 8%	Explore
amacrine cell	5 studies	53% ± 20%	Explore
mesothelial cell	5 studies	27% ± 12%	Explore
T follicular helper cell	5 studies	18% ± 1%	Explore
gamma-delta T cell	5 studies	27% ± 14%	Explore
hematopoietic precursor cell	4 studies	35% ± 17%	Explore
pancreatic A cell	4 studies	35% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	18% ± 2%	Explore
podocyte	4 studies	45% ± 11%	Explore
erythroblast	4 studies	46% ± 31%	Explore
glial cell	4 studies	31% ± 10%	Explore
OFF-bipolar cell	4 studies	57% ± 23%	Explore
ON-bipolar cell	4 studies	46% ± 29%	Explore
precursor B cell	4 studies	36% ± 8%	Explore
innate lymphoid cell	4 studies	32% ± 12%	Explore
retina horizontal cell	4 studies	46% ± 9%	Explore
intermediate monocyte	4 studies	44% ± 18%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	35% ± 7%	Explore
granulocyte	4 studies	37% ± 18%	Explore
enteroendocrine cell	4 studies	33% ± 16%	Explore
goblet cell	4 studies	24% ± 10%	Explore
melanocyte	4 studies	24% ± 7%	Explore
ionocyte	3 studies	26% ± 8%	Explore
respiratory goblet cell	3 studies	25% ± 10%	Explore
squamous epithelial cell	3 studies	40% ± 24%	Explore
type B pancreatic cell	3 studies	56% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	23% ± 4%	Explore
plasmablast	3 studies	27% ± 8%	Explore
glomerular endothelial cell	3 studies	26% ± 4%	Explore
neural crest cell	3 studies	22% ± 1%	Explore
retinal bipolar neuron	3 studies	49% ± 16%	Explore
GABAergic interneuron	3 studies	24% ± 3%	Explore
granule cell	3 studies	22% ± 4%	Explore
GABAergic amacrine cell	3 studies	43% ± 9%	Explore
glycinergic amacrine cell	3 studies	41% ± 8%	Explore
extravillous trophoblast	3 studies	37% ± 9%	Explore
megakaryocyte	3 studies	48% ± 20%	Explore
immature B cell	3 studies	27% ± 9%	Explore
tissue-resident macrophage	3 studies	37% ± 7%	Explore
lymphocyte	3 studies	30% ± 7%	Explore
rod bipolar cell	3 studies	42% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	17% ± 2%	Explore
CD4-positive helper T cell	3 studies	21% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	21% ± 6%	Explore
inflammatory macrophage	3 studies	34% ± 20%	Explore
muscle cell	3 studies	43% ± 14%	Explore
pancreatic ductal cell	3 studies	38% ± 14%	Explore
neural progenitor cell	3 studies	33% ± 13%	Explore
ependymal cell	3 studies	34% ± 13%	Explore
adventitial cell	3 studies	29% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	33% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	30% ± 12%	Explore
brain	17 studies	36% ± 18%	Explore
peripheral blood	14 studies	25% ± 7%	Explore
eye	11 studies	36% ± 14%	Explore
kidney	8 studies	26% ± 7%	Explore
intestine	6 studies	28% ± 11%	Explore
heart	5 studies	21% ± 2%	Explore
lymph node	5 studies	30% ± 18%	Explore
pancreas	4 studies	37% ± 16%	Explore
uterus	4 studies	36% ± 13%	Explore
skin	4 studies	23% ± 7%	Explore
breast	4 studies	21% ± 2%	Explore
adipose	4 studies	29% ± 12%	Explore
liver	4 studies	33% ± 26%	Explore
placenta	3 studies	31% ± 10%	Explore
bone marrow	3 studies	26% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	11586.00	459 / 459	100%	116.92	1115 / 1118
lung	100%	7222.48	578 / 578	100%	102.29	1150 / 1155
brain	99%	6242.33	2628 / 2642	100%	154.99	705 / 705
esophagus	100%	5353.97	1444 / 1445	99%	73.32	182 / 183
ovary	100%	12724.04	180 / 180	99%	66.21	427 / 430
uterus	100%	6011.99	170 / 170	99%	84.70	454 / 459
prostate	100%	5759.56	244 / 245	99%	70.76	498 / 502
thymus	100%	4758.09	650 / 653	99%	74.02	600 / 605
adrenal gland	100%	6532.92	258 / 258	97%	73.72	224 / 230
skin	100%	9464.50	1808 / 1809	97%	88.20	457 / 472
bladder	100%	6783.43	21 / 21	96%	67.80	485 / 504
kidney	100%	5904.79	89 / 89	96%	166.84	861 / 901
intestine	99%	4655.58	960 / 966	91%	49.46	479 / 527
stomach	94%	3341.04	336 / 359	93%	48.86	265 / 286
pancreas	55%	1059.65	179 / 328	99%	76.66	176 / 178
liver	62%	1477.55	141 / 226	54%	20.68	219 / 406
adipose	100%	14598.07	1204 / 1204	0%	0	0 / 0
blood vessel	100%	9859.63	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	61.33	29 / 29
peripheral blood	100%	9302.54	929 / 929	0%	0	0 / 0
spleen	100%	3958.46	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	93.08	45 / 45
heart	95%	4485.68	817 / 861	0%	0	0 / 0
muscle	81%	2479.33	650 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	79%	37.07	63 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1901524	Biological process	regulation of mitophagy
GO_1903214	Biological process	regulation of protein targeting to mitochondrion
GO_0035694	Biological process	mitochondrial protein catabolic process
GO_0051607	Biological process	defense response to virus
GO_0043067	Biological process	regulation of programmed cell death
GO_0043069	Biological process	negative regulation of programmed cell death
GO_0097345	Biological process	mitochondrial outer membrane permeabilization
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0016239	Biological process	positive regulation of macroautophagy
GO_0010917	Biological process	negative regulation of mitochondrial membrane potential
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0071456	Biological process	cellular response to hypoxia
GO_0016020	Cellular component	membrane
GO_0005739	Cellular component	mitochondrion
GO_0016607	Cellular component	nuclear speck
GO_0005635	Cellular component	nuclear envelope
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0005634	Cellular component	nucleus
GO_0042803	Molecular function	protein homodimerization activity
GO_0042802	Molecular function	identical protein binding
GO_0005521	Molecular function	lamin binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	BNIP3L
Protein name	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) BCL2/adenovirus E1B 19kDa interacting protein 3-like (BNIP3L protein) BCL2 interacting protein 3 like
Synonyms	BNIP3A NIX BNIP3H hCG_17158
Description	FUNCTION: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. .
Accessions	ENST00000520409.5 [O60238-2] ENST00000523949.5 ENST00000523515.5 [O60238-2] O60238 ENST00000520077.5 ENST00000380629.7 [O60238-1] Q6IBV1 E5RFE9 H0YBC7 ENST00000518611.5 [O60238-2]

BNIP3L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review