DNAJC3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	31 studies	26% ± 11%	Explore
endothelial cell	28 studies	26% ± 9%	Explore
macrophage	25 studies	26% ± 9%	Explore
natural killer cell	19 studies	21% ± 5%	Explore
plasma cell	19 studies	39% ± 12%	Explore
smooth muscle cell	17 studies	20% ± 5%	Explore
classical monocyte	17 studies	26% ± 11%	Explore
pericyte	16 studies	23% ± 5%	Explore
plasmacytoid dendritic cell	16 studies	30% ± 9%	Explore
monocyte	15 studies	23% ± 5%	Explore
ciliated cell	15 studies	34% ± 12%	Explore
non-classical monocyte	15 studies	23% ± 10%	Explore
mast cell	13 studies	23% ± 5%	Explore
endothelial cell of lymphatic vessel	12 studies	25% ± 6%	Explore
connective tissue cell	12 studies	23% ± 6%	Explore
plasmablast	11 studies	40% ± 23%	Explore
basal cell	11 studies	29% ± 16%	Explore
epithelial cell	11 studies	35% ± 18%	Explore
gamma-delta T cell	11 studies	20% ± 4%	Explore
club cell	10 studies	25% ± 10%	Explore
secretory cell	10 studies	26% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	23% ± 5%	Explore
endothelial cell of artery	10 studies	20% ± 4%	Explore
myofibroblast cell	10 studies	23% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	20% ± 3%	Explore
conventional dendritic cell	9 studies	28% ± 11%	Explore
mature NK T cell	9 studies	18% ± 2%	Explore
microglial cell	9 studies	27% ± 8%	Explore
myeloid cell	9 studies	28% ± 10%	Explore
astrocyte	9 studies	33% ± 16%	Explore
respiratory goblet cell	8 studies	32% ± 16%	Explore
IgA plasma cell	8 studies	33% ± 8%	Explore
mucosal invariant T cell	8 studies	22% ± 5%	Explore
dendritic cell	8 studies	28% ± 16%	Explore
type I pneumocyte	7 studies	22% ± 6%	Explore
capillary endothelial cell	7 studies	20% ± 4%	Explore
IgG plasma cell	7 studies	30% ± 7%	Explore
oligodendrocyte	7 studies	29% ± 11%	Explore
alveolar macrophage	6 studies	23% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	20% ± 4%	Explore
mononuclear phagocyte	6 studies	25% ± 8%	Explore
CD4-positive, alpha-beta T cell	6 studies	17% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	19% ± 3%	Explore
CD8-positive, alpha-beta T cell	6 studies	21% ± 4%	Explore
vein endothelial cell	6 studies	21% ± 6%	Explore
endothelial cell of vascular tree	6 studies	23% ± 5%	Explore
goblet cell	6 studies	32% ± 20%	Explore
T cell	5 studies	16% ± 1%	Explore
ionocyte	5 studies	27% ± 7%	Explore
innate lymphoid cell	5 studies	19% ± 3%	Explore
hepatocyte	5 studies	33% ± 19%	Explore
type II pneumocyte	5 studies	28% ± 11%	Explore
duct epithelial cell	4 studies	27% ± 6%	Explore
pancreatic A cell	4 studies	40% ± 9%	Explore
type B pancreatic cell	4 studies	55% ± 22%	Explore
leukocyte	4 studies	21% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	19% ± 2%	Explore
adventitial cell	4 studies	30% ± 12%	Explore
mesothelial cell	4 studies	19% ± 2%	Explore
lymphocyte	4 studies	26% ± 6%	Explore
regulatory T cell	4 studies	18% ± 1%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	28% ± 7%	Explore
luminal cell of prostate epithelium	4 studies	26% ± 7%	Explore
oligodendrocyte precursor cell	4 studies	32% ± 9%	Explore
abnormal cell	4 studies	20% ± 6%	Explore
pancreatic D cell	3 studies	47% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	18% ± 1%	Explore
hematopoietic precursor cell	3 studies	38% ± 13%	Explore
glomerular endothelial cell	3 studies	21% ± 3%	Explore
kidney loop of Henle epithelial cell	3 studies	21% ± 5%	Explore
extravillous trophoblast	3 studies	23% ± 6%	Explore
retinal pigment epithelial cell	3 studies	33% ± 14%	Explore
mucus secreting cell	3 studies	35% ± 7%	Explore
serous secreting cell	3 studies	33% ± 8%	Explore
cardiac muscle cell	3 studies	18% ± 2%	Explore
tissue-resident macrophage	3 studies	26% ± 7%	Explore
intermediate monocyte	3 studies	31% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	21% ± 4%	Explore
GABAergic neuron	3 studies	49% ± 4%	Explore
glutamatergic neuron	3 studies	54% ± 3%	Explore
B cell	3 studies	18% ± 2%	Explore
pancreatic ductal cell	3 studies	52% ± 14%	Explore
granulocyte monocyte progenitor cell	3 studies	29% ± 14%	Explore
neutrophil	3 studies	19% ± 3%	Explore
enteroendocrine cell	3 studies	23% ± 8%	Explore
transit amplifying cell	3 studies	27% ± 14%	Explore
double negative thymocyte	3 studies	22% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	13 studies	28% ± 13%	Explore
peripheral blood	11 studies	21% ± 5%	Explore
brain	6 studies	38% ± 12%	Explore
intestine	6 studies	21% ± 6%	Explore
pancreas	4 studies	46% ± 15%	Explore
eye	4 studies	23% ± 5%	Explore
uterus	4 studies	27% ± 9%	Explore
liver	4 studies	22% ± 7%	Explore
placenta	3 studies	24% ± 3%	Explore
kidney	3 studies	17% ± 1%	Explore
breast	3 studies	19% ± 4%	Explore
adipose	3 studies	18% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3073.53	1445 / 1445	100%	54.33	183 / 183
lung	100%	4870.36	578 / 578	100%	67.51	1155 / 1155
pancreas	100%	5466.33	328 / 328	100%	65.12	178 / 178
prostate	100%	4347.94	245 / 245	100%	127.53	502 / 502
breast	100%	3630.07	459 / 459	100%	78.15	1117 / 1118
stomach	100%	3529.50	359 / 359	100%	64.17	285 / 286
intestine	100%	3755.61	966 / 966	99%	65.87	524 / 527
liver	100%	5488.15	226 / 226	99%	55.02	403 / 406
bladder	100%	4081.57	21 / 21	99%	57.61	500 / 504
thymus	100%	5269.18	653 / 653	99%	71.63	599 / 605
uterus	100%	4064.48	170 / 170	98%	46.35	452 / 459
kidney	100%	3097.61	89 / 89	98%	65.11	880 / 901
brain	98%	1671.49	2588 / 2642	99%	34.75	698 / 705
skin	100%	3339.93	1809 / 1809	94%	57.44	445 / 472
adrenal gland	100%	3685.02	258 / 258	94%	58.79	216 / 230
ovary	100%	3173.57	180 / 180	88%	22.04	379 / 430
adipose	100%	4077.20	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5119.84	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	37.80	29 / 29
spleen	100%	3537.85	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	37.43	45 / 45
ureter	0%	0	0 / 0	100%	22.38	1 / 1
muscle	98%	1515.37	788 / 803	0%	0	0 / 0
heart	96%	2476.45	829 / 861	0%	0	0 / 0
peripheral blood	96%	3777.21	894 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	68%	23.53	54 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006986	Biological process	response to unfolded protein
GO_0051607	Biological process	defense response to virus
GO_0070417	Biological process	cellular response to cold
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0034975	Biological process	protein folding in endoplasmic reticulum
GO_0036494	Biological process	positive regulation of translation initiation in response to endoplasmic reticulum stress
GO_0051603	Biological process	proteolysis involved in protein catabolic process
GO_1903912	Biological process	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO_0035578	Cellular component	azurophil granule lumen
GO_0005576	Cellular component	extracellular region
GO_0016020	Cellular component	membrane
GO_0005790	Cellular component	smooth endoplasmic reticulum
GO_0070062	Cellular component	extracellular exosome
GO_1903561	Cellular component	extracellular vesicle
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0004860	Molecular function	protein kinase inhibitor activity
GO_0051787	Molecular function	misfolded protein binding
GO_0019901	Molecular function	protein kinase binding
GO_0051087	Molecular function	protein-folding chaperone binding

IV. Literature review

[source]

Gene name	DNAJC3
Protein name	DnaJ homolog subfamily C member 3 DnaJ homolog subfamily C member 3 (Endoplasmic reticulum DNA J domain-containing protein 6) (ER-resident protein ERdj6) (ERdj6) (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Protein kinase inhibitor p58)
Synonyms	P58IPK PRKRI hCG_28703
Description	FUNCTION: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. .
Accessions	Q13217 ENST00000602402.6 ENST00000376795.6 X6R9L0 A8KA82

DNAJC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review