IFIT3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009615Biological processresponse to virus
GO_0051607Biological processdefense response to virus
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0140374Biological processantiviral innate immune response
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameIFIT3
Protein nameInterferon induced protein with tetratricopeptide repeats 3
Interferon-induced protein with tetratricopeptide repeats 3, isoform CRA_a (Interferon-induced protein with tetratricopeptide repeats 3, isoform CRA_b) (cDNA FLJ75638, highly similar to Homo sapiens interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), mRNA)
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G)
SynonymsISG60
IFIT4
hCG_24570
CIG-49
IFI60
DescriptionFUNCTION: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. .

AccessionsA0A7P0T855
A0A7P0TA20
ENST00000679897.1
Q5T765
ENST00000681376.1
ENST00000681178.1
A0A7P0T7D6
ENST00000371818.9
ENST00000681207.1
ENST00000681277.1
ENST00000680037.1
O14879
ENST00000679536.1
ENST00000680779.1
ENST00000679583.1
A0A7P0Z4G0
ENST00000371811.4
ENST00000679781.1
ENST00000679438.1