Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 13 studies | 25% ± 8% | |
non-classical monocyte | 11 studies | 23% ± 6% | |
oligodendrocyte | 8 studies | 26% ± 9% | |
macrophage | 5 studies | 20% ± 4% | |
endothelial cell of vascular tree | 5 studies | 22% ± 6% | |
capillary endothelial cell | 5 studies | 21% ± 4% | |
monocyte | 4 studies | 30% ± 9% | |
alveolar macrophage | 3 studies | 20% ± 3% | |
epithelial cell | 3 studies | 22% ± 5% | |
basal cell | 3 studies | 22% ± 8% | |
endothelial cell of artery | 3 studies | 25% ± 3% | |
glutamatergic neuron | 3 studies | 26% ± 7% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 4 studies | 24% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 99% | 1631.12 | 2625 / 2642 | 99% | 111.03 | 701 / 705 |
breast | 100% | 1693.58 | 458 / 459 | 93% | 103.37 | 1040 / 1118 |
kidney | 100% | 2124.18 | 89 / 89 | 91% | 61.27 | 819 / 901 |
lung | 100% | 2685.71 | 578 / 578 | 88% | 62.02 | 1020 / 1155 |
ovary | 94% | 994.61 | 169 / 180 | 94% | 104.10 | 403 / 430 |
uterus | 99% | 965.08 | 169 / 170 | 87% | 86.74 | 400 / 459 |
thymus | 96% | 924.38 | 627 / 653 | 89% | 46.72 | 539 / 605 |
adrenal gland | 99% | 2315.00 | 256 / 258 | 80% | 48.65 | 183 / 230 |
skin | 88% | 864.33 | 1597 / 1809 | 90% | 86.44 | 424 / 472 |
esophagus | 91% | 969.12 | 1310 / 1445 | 85% | 74.40 | 155 / 183 |
bladder | 100% | 780.33 | 21 / 21 | 72% | 62.12 | 363 / 504 |
intestine | 98% | 1017.08 | 942 / 966 | 70% | 37.07 | 368 / 527 |
stomach | 84% | 680.04 | 302 / 359 | 79% | 43.50 | 227 / 286 |
liver | 85% | 756.88 | 191 / 226 | 75% | 34.38 | 306 / 406 |
pancreas | 59% | 276.51 | 192 / 328 | 87% | 57.82 | 155 / 178 |
prostate | 92% | 637.65 | 225 / 245 | 36% | 14.08 | 180 / 502 |
spleen | 100% | 2388.24 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 2210.70 | 1201 / 1204 | 0% | 0 | 0 / 0 |
heart | 93% | 747.62 | 800 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 92% | 4722.30 | 857 / 929 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 91% | 95.95 | 41 / 45 |
blood vessel | 91% | 1030.37 | 1216 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 65% | 29.49 | 52 / 80 |
lymph node | 0% | 0 | 0 / 0 | 62% | 39.83 | 18 / 29 |
muscle | 51% | 294.97 | 412 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0009615 | Biological process | response to virus |
GO_0051607 | Biological process | defense response to virus |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_0140374 | Biological process | antiviral innate immune response |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005739 | Cellular component | mitochondrion |
GO_0042802 | Molecular function | identical protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0003674 | Molecular function | molecular_function |
Gene name | IFIT3 |
Protein name | Interferon induced protein with tetratricopeptide repeats 3 Interferon-induced protein with tetratricopeptide repeats 3, isoform CRA_a (Interferon-induced protein with tetratricopeptide repeats 3, isoform CRA_b) (cDNA FLJ75638, highly similar to Homo sapiens interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), mRNA) Interferon-induced protein with tetratricopeptide repeats 3 (IFIT-3) (CIG49) (ISG-60) (Interferon-induced 60 kDa protein) (IFI-60K) (Interferon-induced protein with tetratricopeptide repeats 4) (IFIT-4) (Retinoic acid-induced gene G protein) (P60) (RIG-G) |
Synonyms | ISG60 IFIT4 hCG_24570 CIG-49 IFI60 |
Description | FUNCTION: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. . |
Accessions | A0A7P0T855 A0A7P0TA20 ENST00000679897.1 Q5T765 ENST00000681376.1 ENST00000681178.1 A0A7P0T7D6 ENST00000371818.9 ENST00000681207.1 ENST00000681277.1 ENST00000680037.1 O14879 ENST00000679536.1 ENST00000680779.1 ENST00000679583.1 A0A7P0Z4G0 ENST00000371811.4 ENST00000679781.1 ENST00000679438.1 |