MDM4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	36 studies	33% ± 15%	Explore
endothelial cell	30 studies	27% ± 10%	Explore
natural killer cell	24 studies	23% ± 8%	Explore
fibroblast	23 studies	24% ± 8%	Explore
macrophage	21 studies	27% ± 12%	Explore
T cell	20 studies	23% ± 7%	Explore
naive B cell	19 studies	31% ± 8%	Explore
pericyte	17 studies	22% ± 8%	Explore
CD4-positive, alpha-beta T cell	15 studies	26% ± 12%	Explore
CD8-positive, alpha-beta T cell	15 studies	24% ± 9%	Explore
memory B cell	15 studies	24% ± 4%	Explore
plasmacytoid dendritic cell	15 studies	33% ± 12%	Explore
smooth muscle cell	14 studies	21% ± 5%	Explore
astrocyte	14 studies	32% ± 13%	Explore
monocyte	13 studies	26% ± 8%	Explore
oligodendrocyte	13 studies	38% ± 12%	Explore
oligodendrocyte precursor cell	13 studies	32% ± 14%	Explore
microglial cell	13 studies	32% ± 11%	Explore
regulatory T cell	12 studies	20% ± 5%	Explore
mast cell	11 studies	22% ± 11%	Explore
classical monocyte	11 studies	29% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	24% ± 12%	Explore
conventional dendritic cell	11 studies	26% ± 20%	Explore
gamma-delta T cell	11 studies	24% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	26% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	24% ± 8%	Explore
endothelial cell of lymphatic vessel	9 studies	27% ± 10%	Explore
type I pneumocyte	9 studies	25% ± 5%	Explore
GABAergic neuron	9 studies	35% ± 19%	Explore
mature NK T cell	9 studies	23% ± 9%	Explore
adipocyte	9 studies	30% ± 6%	Explore
ciliated cell	9 studies	29% ± 10%	Explore
leukocyte	8 studies	26% ± 8%	Explore
endothelial cell of artery	8 studies	20% ± 3%	Explore
retinal rod cell	8 studies	25% ± 4%	Explore
dendritic cell	8 studies	42% ± 26%	Explore
myeloid cell	8 studies	31% ± 10%	Explore
epithelial cell	8 studies	41% ± 18%	Explore
non-classical monocyte	7 studies	29% ± 16%	Explore
glutamatergic neuron	7 studies	42% ± 24%	Explore
plasma cell	7 studies	35% ± 11%	Explore
retinal cone cell	7 studies	29% ± 9%	Explore
basal cell	7 studies	32% ± 13%	Explore
type II pneumocyte	7 studies	26% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	22% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	27% ± 15%	Explore
capillary endothelial cell	6 studies	19% ± 2%	Explore
abnormal cell	6 studies	28% ± 12%	Explore
neuron	6 studies	39% ± 16%	Explore
interneuron	6 studies	38% ± 21%	Explore
precursor B cell	6 studies	41% ± 12%	Explore
mucosal invariant T cell	6 studies	19% ± 2%	Explore
vein endothelial cell	6 studies	24% ± 14%	Explore
connective tissue cell	6 studies	20% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	31% ± 13%	Explore
pro-B cell	5 studies	37% ± 8%	Explore
myofibroblast cell	5 studies	26% ± 8%	Explore
immature B cell	5 studies	36% ± 10%	Explore
cardiac muscle cell	5 studies	26% ± 4%	Explore
mononuclear phagocyte	5 studies	28% ± 11%	Explore
endothelial cell of vascular tree	5 studies	25% ± 12%	Explore
goblet cell	5 studies	33% ± 20%	Explore
club cell	5 studies	34% ± 12%	Explore
retinal bipolar neuron	4 studies	23% ± 4%	Explore
progenitor cell	4 studies	20% ± 4%	Explore
retina horizontal cell	4 studies	19% ± 4%	Explore
mesothelial cell	4 studies	25% ± 4%	Explore
lymphocyte	4 studies	36% ± 6%	Explore
respiratory goblet cell	4 studies	34% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	22% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	24% ± 14%	Explore
hepatocyte	4 studies	42% ± 14%	Explore
brush cell	4 studies	21% ± 8%	Explore
enteroendocrine cell	4 studies	23% ± 8%	Explore
T follicular helper cell	4 studies	26% ± 5%	Explore
transit amplifying cell	4 studies	29% ± 16%	Explore
hematopoietic precursor cell	3 studies	39% ± 26%	Explore
plasmablast	3 studies	53% ± 24%	Explore
glomerular endothelial cell	3 studies	20% ± 3%	Explore
amacrine cell	3 studies	21% ± 4%	Explore
GABAergic interneuron	3 studies	19% ± 4%	Explore
glial cell	3 studies	28% ± 10%	Explore
retinal pigment epithelial cell	3 studies	33% ± 17%	Explore
tissue-resident macrophage	3 studies	21% ± 5%	Explore
secretory cell	3 studies	19% ± 4%	Explore
germinal center B cell	3 studies	31% ± 11%	Explore
CD4-positive helper T cell	3 studies	19% ± 5%	Explore
innate lymphoid cell	3 studies	21% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	17% ± 0%	Explore
muscle cell	3 studies	30% ± 17%	Explore
pancreatic A cell	3 studies	35% ± 10%	Explore
alveolar macrophage	3 studies	29% ± 10%	Explore
T-helper 17 cell	3 studies	22% ± 3%	Explore
granule cell	3 studies	21% ± 6%	Explore
mural cell	3 studies	28% ± 12%	Explore
double negative thymocyte	3 studies	41% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	34% ± 17%	Explore
lung	12 studies	24% ± 8%	Explore
peripheral blood	11 studies	33% ± 19%	Explore
intestine	7 studies	20% ± 8%	Explore
eye	7 studies	27% ± 11%	Explore
heart	5 studies	23% ± 3%	Explore
kidney	4 studies	20% ± 4%	Explore
liver	4 studies	35% ± 13%	Explore
adipose	4 studies	24% ± 5%	Explore
bone marrow	3 studies	18% ± 2%	Explore
lymph node	3 studies	20% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3893.53	1445 / 1445	100%	18.30	183 / 183
prostate	100%	5444.20	245 / 245	100%	12.15	501 / 502
breast	100%	5610.24	459 / 459	100%	20.18	1115 / 1118
thymus	100%	6473.94	653 / 653	99%	17.79	601 / 605
lung	100%	5491.24	578 / 578	99%	14.54	1147 / 1155
bladder	100%	4585.00	21 / 21	99%	12.04	499 / 504
brain	99%	2847.19	2615 / 2642	100%	20.00	705 / 705
intestine	100%	5085.43	966 / 966	99%	10.84	521 / 527
uterus	100%	5934.94	170 / 170	99%	12.28	453 / 459
pancreas	100%	3806.10	328 / 328	98%	12.33	175 / 178
stomach	100%	3855.88	359 / 359	98%	12.42	281 / 286
ovary	100%	6585.73	180 / 180	98%	11.51	422 / 430
adrenal gland	100%	3621.33	258 / 258	96%	7.97	220 / 230
skin	100%	5511.15	1809 / 1809	95%	13.44	449 / 472
kidney	100%	3714.51	89 / 89	94%	11.31	850 / 901
liver	100%	2599.40	226 / 226	86%	7.90	351 / 406
adipose	100%	5105.43	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	18.11	29 / 29
spleen	100%	8352.53	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	7.28	1 / 1
blood vessel	100%	3466.95	1333 / 1335	0%	0	0 / 0
muscle	100%	2489.74	801 / 803	0%	0	0 / 0
heart	99%	2745.98	855 / 861	0%	0	0 / 0
peripheral blood	98%	4368.06	911 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	9.11	42 / 45
eye	0%	0	0 / 0	76%	6.93	61 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042177	Biological process	negative regulation of protein catabolic process
GO_0016567	Biological process	protein ubiquitination
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0003181	Biological process	atrioventricular valve morphogenesis
GO_0003203	Biological process	endocardial cushion morphogenesis
GO_0003281	Biological process	ventricular septum development
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0065003	Biological process	protein-containing complex assembly
GO_0003283	Biological process	atrial septum development
GO_0003170	Biological process	heart valve development
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0050821	Biological process	protein stabilization
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0051726	Biological process	regulation of cell cycle
GO_0071456	Biological process	cellular response to hypoxia
GO_0030330	Biological process	DNA damage response, signal transduction by p53 class mediator
GO_0005654	Cellular component	nucleoplasm
GO_0017053	Cellular component	transcription repressor complex
GO_0005634	Cellular component	nucleus
GO_0019899	Molecular function	enzyme binding
GO_0008270	Molecular function	zinc ion binding
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	MDM4
Protein name	MDM4 regulator of p53 Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) Mdm4 p53 binding protein transcript variant B MDM4 protein variant G (MDM4 protein variant Y) (MDM4 regulator of p53) (cDNA FLJ56709, highly similar to Mdm4 protein)
Synonyms	MDMX DKFZp781B1423
Description	FUNCTION: Along with MDM2, contributes to TP53 regulation . Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. .
Accessions	Q5T0Y3 ENST00000612738.4 ENST00000616250.4 ENST00000391947.6 A0A087WUE3 Q5T0Y4 M9UVU3 Q5T0Y2 ENST00000454264.6 [O15151-5] ENST00000614459.4 Q68DC0 O15151 ENST00000367179.7 A0A087WZ58 ENST00000444261.1 ENST00000367180.5 A0A087WTR9 ENST00000367183.7 [O15151-4] ENST00000367182.8 [O15151-1] ENST00000507825.3

MDM4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review