TJP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007043Biological processcell-cell junction assembly
GO_0034334Biological processadherens junction maintenance
GO_0051493Biological processregulation of cytoskeleton organization
GO_1901888Biological processregulation of cell junction assembly
GO_1903672Biological processpositive regulation of sprouting angiogenesis
GO_1902396Biological processprotein localization to bicellular tight junction
GO_0045216Biological processcell-cell junction organization
GO_0071896Biological processprotein localization to adherens junction
GO_0031032Biological processactomyosin structure organization
GO_0030036Biological processactin cytoskeleton organization
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030335Biological processpositive regulation of cell migration
GO_2000810Biological processregulation of bicellular tight junction assembly
GO_0035633Biological processmaintenance of blood-brain barrier
GO_2000049Biological processpositive regulation of cell-cell adhesion mediated by cadherin
GO_0090557Biological processestablishment of endothelial intestinal barrier
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0150105Biological processprotein localization to cell-cell junction
GO_1905605Biological processpositive regulation of blood-brain barrier permeability
GO_0098609Biological processcell-cell adhesion
GO_0051497Biological processnegative regulation of stress fiber assembly
GO_0070160Cellular componenttight junction
GO_0005886Cellular componentplasma membrane
GO_0032991Cellular componentprotein-containing complex
GO_0002102Cellular componentpodosome
GO_0043296Cellular componentapical junction complex
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0005737Cellular componentcytoplasm
GO_0005923Cellular componentbicellular tight junction
GO_0005921Cellular componentgap junction
GO_0042995Cellular componentcell projection
GO_0030054Cellular componentcell junction
GO_0045177Cellular componentapical part of cell
GO_0016323Cellular componentbasolateral plasma membrane
GO_0045296Molecular functioncadherin binding
GO_0050839Molecular functioncell adhesion molecule binding
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTJP1
Protein nameTight junction protein ZO-1
Tight junction protein 1 (Tight junction protein ZO-1)
Tight junction protein 1
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
Alternative protein TJP1
SynonymshCG_27621
ZO1
DescriptionFUNCTION: TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton . The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells . Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling . With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). .

AccessionsENST00000545208.6 [Q07157-2]
G5E9E7
ENST00000400007.8
A9CQZ8
H0YKB1
ENST00000346128.10 [Q07157-1]
Q07157
ENST00000495972.6
ENST00000400011.6
H0Y3R8
ENST00000631203.1
Q9H317
ENST00000621049.4
A0A0G2JNH2
ENST00000613680.4
ENST00000614355.5
A0A087X0K9
ENST00000677774.1
ENST00000356107.11
ENST00000612628.3
G3V1L9
A0A7I2V5U5
L0R559