ASCL1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ASCL1 at tissue level.

III. Associated gene sets

GO_0060166Biological processolfactory pit development
GO_0014003Biological processoligodendrocyte development
GO_0010468Biological processregulation of gene expression
GO_0021527Biological processspinal cord association neuron differentiation
GO_0021750Biological processvestibular nucleus development
GO_0007219Biological processNotch signaling pathway
GO_0048485Biological processsympathetic nervous system development
GO_0070849Biological processresponse to epidermal growth factor
GO_0007507Biological processheart development
GO_0048663Biological processneuron fate commitment
GO_0003359Biological processnoradrenergic neuron fate commitment
GO_0021892Biological processcerebral cortex GABAergic interneuron differentiation
GO_0048665Biological processneuron fate specification
GO_0050769Biological processpositive regulation of neurogenesis
GO_0021530Biological processspinal cord oligodendrocyte cell fate specification
GO_0060163Biological processsubpallium neuron fate commitment
GO_0050883Biological processmusculoskeletal movement, spinal reflex action
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0021902Biological processcommitment of neuronal cell to specific neuron type in forebrain
GO_0060165Biological processregulation of timing of subpallium neuron differentiation
GO_0071259Biological processcellular response to magnetism
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0097475Biological processmotor neuron migration
GO_0061549Biological processsympathetic ganglion development
GO_0030182Biological processneuron differentiation
GO_0061103Biological processcarotid body glomus cell differentiation
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0022008Biological processneurogenesis
GO_2000179Biological processpositive regulation of neural precursor cell proliferation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0061102Biological processstomach neuroendocrine cell differentiation
GO_0048935Biological processperipheral nervous system neuron development
GO_0061104Biological processadrenal chromaffin cell differentiation
GO_0048666Biological processneuron development
GO_0007346Biological processregulation of mitotic cell cycle
GO_0021954Biological processcentral nervous system neuron development
GO_0051593Biological processresponse to folic acid
GO_0032526Biological processresponse to retinoic acid
GO_0021987Biological processcerebral cortex development
GO_0061100Biological processlung neuroendocrine cell differentiation
GO_0050767Biological processregulation of neurogenesis
GO_0045747Biological processpositive regulation of Notch signaling pathway
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0003358Biological processnoradrenergic neuron development
GO_0048469Biological processcell maturation
GO_0007400Biological processneuroblast fate determination
GO_0060579Biological processventral spinal cord interneuron fate commitment
GO_0007423Biological processsensory organ development
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0030856Biological processregulation of epithelial cell differentiation
GO_0060487Biological processlung epithelial cell differentiation
GO_0045787Biological processpositive regulation of cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0007405Biological processneuroblast proliferation
GO_0043025Cellular componentneuronal cell body
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0043425Molecular functionbHLH transcription factor binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0003676Molecular functionnucleic acid binding
GO_0003682Molecular functionchromatin binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0070888Molecular functionE-box binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameASCL1
Protein nameAchaete-scute homolog 1 (ASH-1) (hASH1) (Class A basic helix-loop-helix protein 46) (bHLHa46)
SynonymsHASH1
ASH1
BHLHA46
DescriptionFUNCTION: Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. Involved in the regulation of neuroendocrine cell development in the glandular stomach (By similarity). .

AccessionsENST00000266744.4
P50553