AGO4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035196Biological processmiRNA processing
GO_0007130Biological processsynaptonemal complex assembly
GO_0006402Biological processmRNA catabolic process
GO_0090625Biological processsiRNA-mediated gene silencing by mRNA destabilization
GO_0035279Biological processmiRNA-mediated gene silencing by mRNA destabilization
GO_0035278Biological processmiRNA-mediated gene silencing by inhibition of translation
GO_0022604Biological processregulation of cell morphogenesis
GO_0031054Biological processpre-miRNA processing
GO_0035194Biological processregulatory ncRNA-mediated post-transcriptional gene silencing
GO_0043066Biological processnegative regulation of apoptotic process
GO_0008584Biological processmale gonad development
GO_0070922Biological processRISC complex assembly
GO_0010501Biological processRNA secondary structure unwinding
GO_0010586Biological processmiRNA metabolic process
GO_0007140Biological processmale meiotic nuclear division
GO_0070578Cellular componentRISC-loading complex
GO_0016020Cellular componentmembrane
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0016442Cellular componentRISC complex
GO_0005634Cellular componentnucleus
GO_0004521Molecular functionRNA endonuclease activity
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameAGO4
Protein nameProtein argonaute-4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4)
SynonymsEIF2C4
KIAA1567
DescriptionFUNCTION: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Also required for RNA-directed transcription and replication of the human hapatitis delta virus (HDV). .

AccessionsQ9HCK5
ENST00000373210.4