PHIP | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	37 studies	33% ± 14%	Explore
B cell	32 studies	26% ± 8%	Explore
fibroblast	32 studies	29% ± 11%	Explore
pericyte	29 studies	27% ± 11%	Explore
natural killer cell	28 studies	24% ± 6%	Explore
macrophage	27 studies	32% ± 17%	Explore
smooth muscle cell	25 studies	27% ± 8%	Explore
T cell	22 studies	23% ± 7%	Explore
CD8-positive, alpha-beta T cell	22 studies	23% ± 6%	Explore
astrocyte	20 studies	43% ± 18%	Explore
CD4-positive, alpha-beta T cell	20 studies	24% ± 6%	Explore
mast cell	19 studies	26% ± 8%	Explore
ciliated cell	19 studies	46% ± 16%	Explore
regulatory T cell	19 studies	25% ± 6%	Explore
classical monocyte	18 studies	27% ± 11%	Explore
naive B cell	18 studies	24% ± 5%	Explore
memory B cell	18 studies	23% ± 4%	Explore
oligodendrocyte precursor cell	17 studies	41% ± 15%	Explore
monocyte	16 studies	28% ± 13%	Explore
endothelial cell of lymphatic vessel	16 studies	34% ± 14%	Explore
oligodendrocyte	16 studies	50% ± 17%	Explore
basal cell	15 studies	37% ± 19%	Explore
non-classical monocyte	15 studies	27% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	24% ± 5%	Explore
microglial cell	15 studies	47% ± 17%	Explore
gamma-delta T cell	15 studies	24% ± 9%	Explore
epithelial cell	14 studies	40% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	23% ± 4%	Explore
mature NK T cell	13 studies	23% ± 6%	Explore
glutamatergic neuron	12 studies	53% ± 22%	Explore
connective tissue cell	12 studies	27% ± 8%	Explore
mucosal invariant T cell	12 studies	22% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	24% ± 4%	Explore
GABAergic neuron	11 studies	53% ± 21%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	23% ± 4%	Explore
myofibroblast cell	11 studies	27% ± 9%	Explore
plasmacytoid dendritic cell	11 studies	24% ± 6%	Explore
type I pneumocyte	10 studies	35% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	22% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	26% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	22% ± 5%	Explore
neuron	10 studies	46% ± 20%	Explore
dendritic cell	10 studies	38% ± 13%	Explore
type II pneumocyte	9 studies	34% ± 10%	Explore
capillary endothelial cell	9 studies	24% ± 7%	Explore
vein endothelial cell	9 studies	27% ± 15%	Explore
myeloid cell	9 studies	34% ± 9%	Explore
progenitor cell	8 studies	37% ± 14%	Explore
mesothelial cell	8 studies	31% ± 12%	Explore
amacrine cell	8 studies	50% ± 12%	Explore
retinal rod cell	8 studies	41% ± 18%	Explore
club cell	8 studies	42% ± 13%	Explore
adipocyte	8 studies	31% ± 9%	Explore
endothelial cell of artery	8 studies	20% ± 5%	Explore
endothelial cell of vascular tree	8 studies	27% ± 16%	Explore
plasmablast	7 studies	42% ± 22%	Explore
leukocyte	7 studies	35% ± 13%	Explore
retinal ganglion cell	7 studies	43% ± 20%	Explore
retinal cone cell	7 studies	43% ± 13%	Explore
T follicular helper cell	7 studies	20% ± 4%	Explore
hematopoietic precursor cell	6 studies	33% ± 17%	Explore
plasma cell	6 studies	32% ± 13%	Explore
conventional dendritic cell	6 studies	29% ± 16%	Explore
abnormal cell	6 studies	31% ± 13%	Explore
interneuron	6 studies	68% ± 17%	Explore
lymphocyte	6 studies	35% ± 13%	Explore
retina horizontal cell	6 studies	53% ± 13%	Explore
Mueller cell	6 studies	40% ± 18%	Explore
goblet cell	6 studies	34% ± 23%	Explore
secretory cell	5 studies	23% ± 6%	Explore
enteroendocrine cell	5 studies	30% ± 12%	Explore
retinal bipolar neuron	5 studies	48% ± 13%	Explore
hematopoietic stem cell	5 studies	26% ± 9%	Explore
precursor B cell	5 studies	30% ± 11%	Explore
pro-B cell	5 studies	37% ± 5%	Explore
brush cell	5 studies	33% ± 10%	Explore
cardiac muscle cell	5 studies	36% ± 8%	Explore
respiratory goblet cell	5 studies	42% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	25% ± 9%	Explore
innate lymphoid cell	5 studies	23% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	22% ± 5%	Explore
deuterosomal cell	4 studies	41% ± 6%	Explore
ionocyte	4 studies	29% ± 9%	Explore
pancreatic A cell	4 studies	42% ± 23%	Explore
podocyte	4 studies	35% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	21% ± 4%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	44% ± 15%	Explore
glial cell	4 studies	39% ± 16%	Explore
granule cell	4 studies	55% ± 5%	Explore
immature B cell	4 studies	24% ± 3%	Explore
retinal pigment epithelial cell	4 studies	40% ± 17%	Explore
mononuclear phagocyte	4 studies	33% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	19% ± 4%	Explore
hepatocyte	4 studies	35% ± 9%	Explore
muscle cell	4 studies	34% ± 18%	Explore
alveolar macrophage	4 studies	41% ± 16%	Explore
exhausted T cell	3 studies	26% ± 5%	Explore
glomerular endothelial cell	3 studies	23% ± 4%	Explore
epithelial cell of proximal tubule	3 studies	21% ± 6%	Explore
neural crest cell	3 studies	39% ± 15%	Explore
GABAergic interneuron	3 studies	53% ± 5%	Explore
GABAergic amacrine cell	3 studies	67% ± 13%	Explore
OFF-bipolar cell	3 studies	53% ± 13%	Explore
ON-bipolar cell	3 studies	57% ± 13%	Explore
glycinergic amacrine cell	3 studies	57% ± 7%	Explore
rod bipolar cell	3 studies	58% ± 15%	Explore
erythroblast	3 studies	32% ± 14%	Explore
CD4-positive helper T cell	3 studies	22% ± 5%	Explore
pancreatic ductal cell	3 studies	42% ± 20%	Explore
neural progenitor cell	3 studies	55% ± 20%	Explore
ependymal cell	3 studies	53% ± 13%	Explore
granulocyte	3 studies	24% ± 7%	Explore
neutrophil	3 studies	20% ± 3%	Explore
adventitial cell	3 studies	27% ± 6%	Explore
chondrocyte	3 studies	37% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	34% ± 9%	Explore
Schwann cell	3 studies	35% ± 15%	Explore
transit amplifying cell	3 studies	47% ± 36%	Explore
T-helper 17 cell	3 studies	20% ± 1%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	21% ± 4%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	18% ± 3%	Explore
double negative thymocyte	3 studies	35% ± 13%	Explore
renal principal cell	3 studies	22% ± 8%	Explore
mural cell	3 studies	49% ± 8%	Explore
mucus secreting cell	3 studies	33% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	19 studies	48% ± 21%	Explore
lung	17 studies	29% ± 10%	Explore
peripheral blood	15 studies	26% ± 10%	Explore
eye	10 studies	43% ± 18%	Explore
kidney	6 studies	24% ± 4%	Explore
intestine	6 studies	25% ± 10%	Explore
heart	5 studies	29% ± 7%	Explore
liver	5 studies	34% ± 17%	Explore
bone marrow	4 studies	25% ± 6%	Explore
adipose	4 studies	28% ± 8%	Explore
pancreas	3 studies	43% ± 21%	Explore
lymph node	3 studies	25% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3690.18	1445 / 1445	100%	28.19	183 / 183
prostate	100%	4130.29	245 / 245	100%	13.83	501 / 502
uterus	100%	5936.94	170 / 170	100%	15.61	458 / 459
ovary	100%	5079.91	180 / 180	100%	14.99	429 / 430
lung	100%	4982.72	578 / 578	100%	15.88	1151 / 1155
breast	100%	5373.76	459 / 459	99%	21.04	1112 / 1118
thymus	100%	4255.02	653 / 653	99%	14.28	600 / 605
brain	99%	2902.51	2625 / 2642	100%	10.69	702 / 705
bladder	100%	4569.52	21 / 21	98%	11.82	492 / 504
pancreas	99%	2658.74	326 / 328	98%	10.92	174 / 178
stomach	100%	3084.46	359 / 359	97%	15.52	277 / 286
adrenal gland	100%	2251.46	258 / 258	96%	11.29	220 / 230
intestine	100%	4304.60	966 / 966	96%	11.39	504 / 527
kidney	100%	2226.83	89 / 89	92%	11.71	831 / 901
skin	100%	4174.28	1809 / 1809	89%	11.03	418 / 472
liver	94%	1121.67	212 / 226	66%	4.67	268 / 406
blood vessel	100%	4591.32	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	9.18	29 / 29
muscle	100%	2984.64	803 / 803	0%	0	0 / 0
spleen	100%	4110.18	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	17.59	45 / 45
ureter	0%	0	0 / 0	100%	3.68	1 / 1
adipose	100%	4530.07	1203 / 1204	0%	0	0 / 0
heart	98%	2247.52	841 / 861	0%	0	0 / 0
peripheral blood	84%	3153.91	783 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	64%	5.69	51 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0022604	Biological process	regulation of cell morphogenesis
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0008360	Biological process	regulation of cell shape
GO_2001237	Biological process	negative regulation of extrinsic apoptotic signaling pathway
GO_0008286	Biological process	insulin receptor signaling pathway
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0001932	Biological process	regulation of protein phosphorylation
GO_0007010	Biological process	cytoskeleton organization
GO_0043568	Biological process	positive regulation of insulin-like growth factor receptor signaling pathway
GO_0045840	Biological process	positive regulation of mitotic nuclear division
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0005634	Cellular component	nucleus
GO_0070577	Molecular function	lysine-acetylated histone binding
GO_0005158	Molecular function	insulin receptor binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PHIP
Protein name	PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11) Pleckstrin homology domain interacting protein
Synonyms	DCAF14 WDR11
Description	FUNCTION: Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. .
Accessions	ENST00000700114.1 ENST00000275034.5 ENST00000700013.1 A0A8V8TQM4 ENST00000700115.1 A0A8V8TPV5 A0A8V8TPK0 ENST00000700119.1 A0A8V8TP75 ENST00000700012.1 ENST00000700171.1 A0A8V8TQP5 A0A8V8TQZ3 ENST00000700118.1 Q8WWQ0 A0A8V8TPB8

PHIP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review