GSTP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	43 studies	63% ± 22%	Explore
fibroblast	42 studies	66% ± 23%	Explore
B cell	41 studies	41% ± 19%	Explore
endothelial cell	41 studies	58% ± 21%	Explore
natural killer cell	40 studies	64% ± 18%	Explore
CD8-positive, alpha-beta T cell	35 studies	45% ± 19%	Explore
pericyte	34 studies	69% ± 21%	Explore
conventional dendritic cell	32 studies	84% ± 15%	Explore
T cell	31 studies	41% ± 19%	Explore
dendritic cell	29 studies	77% ± 20%	Explore
classical monocyte	29 studies	75% ± 20%	Explore
smooth muscle cell	28 studies	70% ± 23%	Explore
CD4-positive, alpha-beta T cell	27 studies	34% ± 18%	Explore
plasma cell	26 studies	64% ± 21%	Explore
non-classical monocyte	26 studies	78% ± 17%	Explore
epithelial cell	26 studies	79% ± 26%	Explore
plasmacytoid dendritic cell	25 studies	75% ± 10%	Explore
monocyte	23 studies	70% ± 20%	Explore
basal cell	23 studies	83% ± 18%	Explore
mature NK T cell	22 studies	50% ± 18%	Explore
regulatory T cell	22 studies	29% ± 14%	Explore
mast cell	21 studies	45% ± 20%	Explore
endothelial cell of lymphatic vessel	21 studies	72% ± 11%	Explore
ciliated cell	20 studies	83% ± 25%	Explore
gamma-delta T cell	20 studies	52% ± 16%	Explore
memory B cell	19 studies	32% ± 14%	Explore
connective tissue cell	19 studies	72% ± 19%	Explore
naive B cell	18 studies	37% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	65% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	66% ± 13%	Explore
capillary endothelial cell	16 studies	49% ± 19%	Explore
myeloid cell	15 studies	66% ± 26%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	29% ± 6%	Explore
myofibroblast cell	14 studies	75% ± 20%	Explore
endothelial cell of artery	14 studies	58% ± 21%	Explore
endothelial cell of vascular tree	13 studies	61% ± 19%	Explore
plasmablast	12 studies	68% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	51% ± 14%	Explore
secretory cell	12 studies	90% ± 13%	Explore
vein endothelial cell	12 studies	57% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	36% ± 11%	Explore
club cell	11 studies	77% ± 32%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	45% ± 6%	Explore
mucosal invariant T cell	11 studies	33% ± 7%	Explore
type I pneumocyte	10 studies	79% ± 25%	Explore
type II pneumocyte	10 studies	77% ± 28%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	47% ± 14%	Explore
progenitor cell	10 studies	85% ± 17%	Explore
abnormal cell	10 studies	64% ± 19%	Explore
goblet cell	10 studies	71% ± 16%	Explore
mesothelial cell	10 studies	80% ± 20%	Explore
innate lymphoid cell	9 studies	51% ± 17%	Explore
leukocyte	9 studies	56% ± 21%	Explore
neutrophil	9 studies	48% ± 20%	Explore
astrocyte	9 studies	42% ± 22%	Explore
enterocyte	9 studies	52% ± 23%	Explore
erythrocyte	9 studies	47% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	59% ± 22%	Explore
neuron	8 studies	59% ± 24%	Explore
IgG plasma cell	8 studies	51% ± 14%	Explore
retinal rod cell	8 studies	48% ± 26%	Explore
hematopoietic stem cell	8 studies	81% ± 25%	Explore
brush cell	8 studies	66% ± 27%	Explore
ionocyte	7 studies	82% ± 13%	Explore
respiratory goblet cell	7 studies	88% ± 14%	Explore
platelet	7 studies	30% ± 17%	Explore
mononuclear phagocyte	7 studies	67% ± 25%	Explore
epithelial cell of proximal tubule	7 studies	61% ± 18%	Explore
IgA plasma cell	7 studies	53% ± 11%	Explore
microglial cell	7 studies	56% ± 19%	Explore
alveolar macrophage	6 studies	74% ± 23%	Explore
hematopoietic precursor cell	6 studies	79% ± 19%	Explore
kidney loop of Henle epithelial cell	6 studies	85% ± 9%	Explore
renal alpha-intercalated cell	6 studies	90% ± 3%	Explore
erythroblast	6 studies	55% ± 22%	Explore
transit amplifying cell	6 studies	72% ± 21%	Explore
T follicular helper cell	6 studies	23% ± 4%	Explore
intermediate monocyte	6 studies	77% ± 25%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	32% ± 14%	Explore
melanocyte	6 studies	70% ± 27%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	48% ± 17%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	41% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	51% ± 10%	Explore
exhausted T cell	5 studies	52% ± 18%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	88% ± 10%	Explore
oligodendrocyte	5 studies	37% ± 9%	Explore
intestinal crypt stem cell	5 studies	76% ± 29%	Explore
retinal ganglion cell	5 studies	70% ± 26%	Explore
OFF-bipolar cell	5 studies	47% ± 28%	Explore
ON-bipolar cell	5 studies	49% ± 28%	Explore
retinal cone cell	5 studies	49% ± 29%	Explore
neuroendocrine cell	5 studies	89% ± 13%	Explore
glial cell	5 studies	57% ± 15%	Explore
immature B cell	5 studies	51% ± 24%	Explore
precursor B cell	5 studies	50% ± 21%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	46% ± 17%	Explore
CD4-positive helper T cell	5 studies	27% ± 11%	Explore
granulocyte	5 studies	52% ± 15%	Explore
keratinocyte	5 studies	74% ± 26%	Explore
deuterosomal cell	4 studies	87% ± 13%	Explore
duct epithelial cell	4 studies	94% ± 3%	Explore
precursor cell	4 studies	76% ± 33%	Explore
squamous epithelial cell	4 studies	71% ± 17%	Explore
pancreatic A cell	4 studies	48% ± 19%	Explore
monocyte-derived dendritic cell	4 studies	79% ± 19%	Explore
glomerular endothelial cell	4 studies	56% ± 15%	Explore
podocyte	4 studies	84% ± 8%	Explore
enteroendocrine cell	4 studies	71% ± 16%	Explore
retinal bipolar neuron	4 studies	51% ± 30%	Explore
lymphocyte	4 studies	62% ± 28%	Explore
megakaryocyte	4 studies	47% ± 18%	Explore
pro-B cell	4 studies	64% ± 9%	Explore
Schwann cell	4 studies	57% ± 29%	Explore
amacrine cell	4 studies	45% ± 14%	Explore
retina horizontal cell	4 studies	48% ± 17%	Explore
retinal pigment epithelial cell	4 studies	67% ± 27%	Explore
adventitial cell	4 studies	79% ± 15%	Explore
mucus secreting cell	4 studies	80% ± 15%	Explore
Mueller cell	4 studies	54% ± 21%	Explore
acinar cell	4 studies	57% ± 11%	Explore
muscle cell	4 studies	48% ± 19%	Explore
germinal center B cell	4 studies	58% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	81% ± 8%	Explore
inflammatory macrophage	4 studies	51% ± 25%	Explore
glutamatergic neuron	4 studies	27% ± 12%	Explore
oligodendrocyte precursor cell	4 studies	56% ± 17%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	78% ± 31%	Explore
group 3 innate lymphoid cell	4 studies	57% ± 6%	Explore
T-helper 17 cell	4 studies	44% ± 25%	Explore
Langerhans cell	3 studies	66% ± 20%	Explore
hillock cell	3 studies	76% ± 32%	Explore
kidney connecting tubule epithelial cell	3 studies	84% ± 12%	Explore
renal beta-intercalated cell	3 studies	89% ± 4%	Explore
neural crest cell	3 studies	87% ± 6%	Explore
renal principal cell	3 studies	90% ± 6%	Explore
extravillous trophoblast	3 studies	92% ± 6%	Explore
placental villous trophoblast	3 studies	95% ± 5%	Explore
common myeloid progenitor	3 studies	68% ± 30%	Explore
serous secreting cell	3 studies	52% ± 20%	Explore
tissue-resident macrophage	3 studies	55% ± 28%	Explore
intraepithelial lymphocyte	3 studies	61% ± 15%	Explore
rod bipolar cell	3 studies	55% ± 21%	Explore
chondrocyte	3 studies	37% ± 6%	Explore
myoepithelial cell	3 studies	83% ± 14%	Explore
luminal cell of prostate epithelium	3 studies	40% ± 8%	Explore
IgM plasma cell	3 studies	52% ± 18%	Explore
pancreatic ductal cell	3 studies	84% ± 13%	Explore
granulocyte monocyte progenitor cell	3 studies	81% ± 17%	Explore
interneuron	3 studies	42% ± 29%	Explore
T-helper 1 cell	3 studies	45% ± 13%	Explore
double negative thymocyte	3 studies	67% ± 12%	Explore
progenitor cell of mammary luminal epithelium	3 studies	76% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	55% ± 11%	Explore
lung	19 studies	65% ± 21%	Explore
intestine	12 studies	59% ± 20%	Explore
eye	10 studies	51% ± 21%	Explore
kidney	9 studies	64% ± 14%	Explore
brain	9 studies	34% ± 13%	Explore
bone marrow	7 studies	46% ± 23%	Explore
lymph node	7 studies	44% ± 27%	Explore
liver	6 studies	44% ± 14%	Explore
pancreas	5 studies	47% ± 13%	Explore
uterus	5 studies	75% ± 24%	Explore
placenta	4 studies	76% ± 19%	Explore
esophagus	4 studies	74% ± 16%	Explore
prostate	4 studies	66% ± 29%	Explore
skin	4 studies	64% ± 14%	Explore
breast	4 studies	66% ± 8%	Explore
heart	3 studies	40% ± 15%	Explore
adipose	3 studies	32% ± 17%	Explore
adrenal gland	3 studies	52% ± 5%	Explore
thymus	3 studies	69% ± 22%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	12078.70	180 / 180	100%	1180.04	429 / 430
thymus	100%	25791.90	653 / 653	100%	1068.72	603 / 605
esophagus	100%	35126.29	1445 / 1445	99%	1346.63	182 / 183
uterus	100%	14775.86	170 / 170	99%	1886.41	455 / 459
intestine	100%	12043.63	966 / 966	98%	1161.61	518 / 527
lung	100%	20069.43	577 / 578	98%	1442.96	1132 / 1155
bladder	100%	16673.29	21 / 21	97%	1354.59	488 / 504
skin	100%	24026.03	1809 / 1809	96%	1349.43	451 / 472
stomach	100%	12118.32	358 / 359	95%	925.08	273 / 286
brain	98%	6663.29	2590 / 2642	96%	440.94	676 / 705
pancreas	99%	7723.87	324 / 328	93%	1051.15	166 / 178
kidney	100%	17186.79	89 / 89	86%	613.25	778 / 901
adrenal gland	100%	10755.21	258 / 258	74%	288.76	170 / 230
breast	100%	12072.25	459 / 459	49%	320.02	547 / 1118
prostate	100%	12621.43	245 / 245	27%	100.33	138 / 502
lymph node	0%	0	0 / 0	100%	1078.12	29 / 29
spleen	100%	10429.61	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	2384.76	45 / 45
ureter	0%	0	0 / 0	100%	421.18	1 / 1
adipose	100%	11528.24	1202 / 1204	0%	0	0 / 0
blood vessel	100%	15662.36	1329 / 1335	0%	0	0 / 0
muscle	98%	8262.60	784 / 803	0%	0	0 / 0
heart	97%	9368.13	831 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	1427.75	76 / 80
peripheral blood	88%	9640.49	818 / 929	0%	0	0 / 0
liver	3%	136.88	6 / 226	12%	100.56	47 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051122	Biological process	hepoxilin biosynthetic process
GO_0006469	Biological process	negative regulation of protein kinase activity
GO_0006805	Biological process	xenobiotic metabolic process
GO_0043651	Biological process	linoleic acid metabolic process
GO_0098869	Biological process	cellular oxidant detoxification
GO_0048147	Biological process	negative regulation of fibroblast proliferation
GO_0070372	Biological process	regulation of ERK1 and ERK2 cascade
GO_0070373	Biological process	negative regulation of ERK1 and ERK2 cascade
GO_2001237	Biological process	negative regulation of extrinsic apoptotic signaling pathway
GO_0071638	Biological process	negative regulation of monocyte chemotactic protein-1 production
GO_0002674	Biological process	negative regulation of acute inflammatory response
GO_0051771	Biological process	negative regulation of nitric-oxide synthase biosynthetic process
GO_0032691	Biological process	negative regulation of interleukin-1 beta production
GO_0032872	Biological process	regulation of stress-activated MAPK cascade
GO_0043508	Biological process	negative regulation of JUN kinase activity
GO_0009890	Biological process	negative regulation of biosynthetic process
GO_0032873	Biological process	negative regulation of stress-activated MAPK cascade
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0070664	Biological process	negative regulation of leukocyte proliferation
GO_0035726	Biological process	common myeloid progenitor cell proliferation
GO_0006693	Biological process	prostaglandin metabolic process
GO_0000302	Biological process	response to reactive oxygen species
GO_0007417	Biological process	central nervous system development
GO_1901687	Biological process	glutathione derivative biosynthetic process
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0043409	Biological process	negative regulation of MAPK cascade
GO_0032930	Biological process	positive regulation of superoxide anion generation
GO_0035732	Biological process	nitric oxide storage
GO_0043407	Biological process	negative regulation of MAP kinase activity
GO_0032720	Biological process	negative regulation of tumor necrosis factor production
GO_0010804	Biological process	negative regulation of tumor necrosis factor-mediated signaling pathway
GO_0043124	Biological process	negative regulation of canonical NF-kappaB signal transduction
GO_0006749	Biological process	glutathione metabolic process
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005739	Cellular component	mitochondrion
GO_0070062	Cellular component	extracellular exosome
GO_0034774	Cellular component	secretory granule lumen
GO_1904813	Cellular component	ficolin-1-rich granule lumen
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0097057	Cellular component	TRAF2-GSTP1 complex
GO_0031982	Cellular component	vesicle
GO_0005634	Cellular component	nucleus
GO_0035730	Molecular function	S-nitrosoglutathione binding
GO_0008432	Molecular function	JUN kinase binding
GO_0070026	Molecular function	nitric oxide binding
GO_0004602	Molecular function	glutathione peroxidase activity
GO_0005504	Molecular function	fatty acid binding
GO_0004364	Molecular function	glutathione transferase activity
GO_0019207	Molecular function	kinase regulator activity
GO_0035731	Molecular function	dinitrosyl-iron complex binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	GSTP1
Protein name	Glutathione S-transferase P (EC 2.5.1.18) (GST class-pi) (GSTP1-1) glutathione transferase (EC 2.5.1.18) (GST class-pi) Glutathione S-transferase pi Glutathione S-transferase P Glutathione S-transferase pi 1 Glutathione S-transferase (EC 2.5.1.18) (GST class-pi) Mutant GSTP1 glutathione transferase (EC 2.5.1.18)
Synonyms	HEL-S-22 GST3 hCG_21055 FAEES3
Description	FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) . Participates in the formation of novel hepoxilin regioisomers . Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. . FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. . FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. . FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. .
Accessions	ENST00000498765.5 ENST00000398606.10 ENST00000646888.1 P09211 V9HWE9 B2C310 A0A087X2E9 C7DJS2 A0A3B6XSH2 C7DJS1 A0A2R8Y5E5 A0A2P1FDF0 ENST00000398603.6 A8MX94 ENST00000495996.1 A0A087X243 A0A0M4UT83 A0A0M5MRY8 Q5D6A5

GSTP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review