I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| mesothelial cell | 9 studies | 53% ± 16% | |
| podocyte | 5 studies | 74% ± 8% | |
| connective tissue cell | 3 studies | 21% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| mesothelial cell | 9 studies | 53% ± 16% | |
| podocyte | 5 studies | 74% ± 8% | |
| connective tissue cell | 3 studies | 21% ± 6% |
Insufficient scRNA-seq data for expression of WT1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 6157.48 | 180 / 180 | 99% | 84.09 | 427 / 430 |
| uterus | 99% | 8051.36 | 169 / 170 | 26% | 2.91 | 119 / 459 |
| kidney | 96% | 1748.90 | 85 / 89 | 24% | 1.24 | 218 / 901 |
| spleen | 100% | 2624.80 | 241 / 241 | 0% | 0 | 0 / 0 |
| heart | 71% | 333.71 | 609 / 861 | 0% | 0 | 0 / 0 |
| adipose | 44% | 1598.33 | 528 / 1204 | 0% | 0 | 0 / 0 |
| prostate | 18% | 74.53 | 44 / 245 | 22% | 0.39 | 108 / 502 |
| pancreas | 1% | 1.21 | 2 / 328 | 37% | 1.00 | 66 / 178 |
| lung | 14% | 93.59 | 79 / 578 | 19% | 0.68 | 222 / 1155 |
| stomach | 3% | 25.15 | 12 / 359 | 29% | 0.77 | 84 / 286 |
| intestine | 8% | 30.14 | 74 / 966 | 24% | 0.65 | 124 / 527 |
| breast | 0% | 0 | 0 / 459 | 27% | 2.37 | 302 / 1118 |
| bladder | 5% | 18.48 | 1 / 21 | 14% | 0.46 | 73 / 504 |
| esophagus | 4% | 15.22 | 60 / 1445 | 7% | 0.14 | 13 / 183 |
| brain | 5% | 14.10 | 130 / 2642 | 6% | 0.19 | 41 / 705 |
| skin | 0% | 0.66 | 2 / 1809 | 9% | 0.35 | 42 / 472 |
| blood vessel | 7% | 40.28 | 99 / 1335 | 0% | 0 | 0 / 0 |
| liver | 0% | 1.65 | 1 / 226 | 6% | 0.16 | 24 / 406 |
| thymus | 1% | 1.61 | 4 / 653 | 5% | 0.13 | 28 / 605 |
| tonsil | 0% | 0 | 0 / 0 | 4% | 0.09 | 2 / 45 |
| adrenal gland | 0% | 0.98 | 1 / 258 | 3% | 0.05 | 6 / 230 |
| peripheral blood | 2% | 7.90 | 20 / 929 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.27 | 1 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0060231 | Biological process | mesenchymal to epithelial transition |
| GO_0001657 | Biological process | ureteric bud development |
| GO_0001658 | Biological process | branching involved in ureteric bud morphogenesis |
| GO_0008406 | Biological process | gonad development |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0035802 | Biological process | adrenal cortex formation |
| GO_0071371 | Biological process | cellular response to gonadotropin stimulus |
| GO_0072112 | Biological process | podocyte differentiation |
| GO_0061032 | Biological process | visceral serous pericardium development |
| GO_0009888 | Biological process | tissue development |
| GO_0030855 | Biological process | epithelial cell differentiation |
| GO_0007507 | Biological process | heart development |
| GO_0007356 | Biological process | thorax and anterior abdomen determination |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0003156 | Biological process | regulation of animal organ formation |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0072166 | Biological process | posterior mesonephric tubule development |
| GO_0072284 | Biological process | metanephric S-shaped body morphogenesis |
| GO_0001570 | Biological process | vasculogenesis |
| GO_0001822 | Biological process | kidney development |
| GO_0044027 | Biological process | negative regulation of gene expression via chromosomal CpG island methylation |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0032836 | Biological process | glomerular basement membrane development |
| GO_0060923 | Biological process | cardiac muscle cell fate commitment |
| GO_0060539 | Biological process | diaphragm development |
| GO_2001076 | Biological process | positive regulation of metanephric ureteric bud development |
| GO_0072207 | Biological process | metanephric epithelium development |
| GO_0072302 | Biological process | negative regulation of metanephric glomerular mesangial cell proliferation |
| GO_0060421 | Biological process | positive regulation of heart growth |
| GO_0071320 | Biological process | cellular response to cAMP |
| GO_0072075 | Biological process | metanephric mesenchyme development |
| GO_0008380 | Biological process | RNA splicing |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0007281 | Biological process | germ cell development |
| GO_0030539 | Biological process | male genitalia development |
| GO_0030325 | Biological process | adrenal gland development |
| GO_1902895 | Biological process | positive regulation of miRNA transcription |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_2000020 | Biological process | positive regulation of male gonad development |
| GO_0008584 | Biological process | male gonad development |
| GO_0032835 | Biological process | glomerulus development |
| GO_2000195 | Biological process | negative regulation of female gonad development |
| GO_0043010 | Biological process | camera-type eye development |
| GO_0007530 | Biological process | sex determination |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0030308 | Biological process | negative regulation of cell growth |
| GO_0005730 | Cellular component | nucleolus |
| GO_0016607 | Cellular component | nuclear speck |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_0043565 | Molecular function | sequence-specific DNA binding |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_0044729 | Molecular function | hemi-methylated DNA-binding |
| GO_0010385 | Molecular function | double-stranded methylated DNA binding |
| GO_0003700 | Molecular function | DNA-binding transcription factor activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0003723 | Molecular function | RNA binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0070742 | Molecular function | C2H2 zinc finger domain binding |
| Gene name | WT1 |
| Protein name | Wilms tumor 1 WT1 protein Truncated Wilm's tumor supressor protein Wilms tumor 1, isoform CRA_f (Wilms tumor protein isoform Ex4a(+)) WT1 transcription factor Wilms tumor protein Wilms' tumor gene Wilms tumor protein (WT33) |
| Synonyms | hCG_27321 |
| Description | FUNCTION: Transcription factor that plays an important role in cellular development and cell survival . Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' . Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors . Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing . Isoform 1 has lower affinity for DNA, and can bind RNA . . |
| Accessions | A0A494C0I9 A0A481V744 U5LSU3 A0A1W2PR07 A0FJ57 ENST00000530998.5 [P19544-9] ENST00000640146.2 ENST00000379079.8 [P19544-6] Q6LBI3 Q93046 J3KNN9 ENST00000448076.9 A8MN20 W5S707 H0Y3F0 A0A1W2PQQ0 P19544 ENST00000452863 H0YED9 A0A0H5AUY0 ENST00000452863.10 [P19544-7] V9GZX5 ENST00000379077.9 H0Y7K5 ENST00000332351.9 ENST00000639563.3 [P19544-8] ENST00000639563 Q6LD16 ENST00000527882.5 A0FJ58 A0A0A0MT54 ENST00000651459.1 Q6PI38 |
