MICAL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019417Biological processsulfur oxidation
GO_0030042Biological processactin filament depolymerization
GO_0007165Biological processsignal transduction
GO_0007010Biological processcytoskeleton organization
GO_1903305Biological processregulation of regulated secretory pathway
GO_0051017Biological processactin filament bundle assembly
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_1990026Cellular componenthippocampal mossy fiber expansion
GO_0005884Cellular componentactin filament
GO_0045171Cellular componentintercellular bridge
GO_0005882Cellular componentintermediate filament
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0016709Molecular functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO_0071949Molecular functionFAD binding
GO_0106294Molecular functionNADPH oxidase H202-forming activity
GO_0019901Molecular functionprotein kinase binding
GO_0051015Molecular functionactin filament binding
GO_0031267Molecular functionsmall GTPase binding
GO_0004497Molecular functionmonooxygenase activity
GO_0016174Molecular functionNAD(P)H oxidase H2O2-forming activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameMICAL1
Protein nameMicrotubule associated monooxygenase, calponin and LIM domain containing 1
[F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (EC 1.6.3.1) (Molecule interacting with CasL protein 1) (MICAL-1) (NEDD9-interacting protein with calponin homology and LIM domains)
Molecule interacting with CasL protein 1 (EC 1.14.13.225) (EC 1.6.3.1)
SynonymsMICAL
NICAL
DescriptionFUNCTION: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization . In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) . Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export . .

AccessionsENST00000358807.8 [Q8TDZ2-1]
ENST00000358577.7 [Q8TDZ2-2]
ENST00000630715.2 [Q8TDZ2-4]
ENST00000431946.1
ENST00000433205.1
Q8TDZ2
H0Y6Z4
A0A1S5UZH2
Q5TED7