Name | Number of supported studies | Average coverage | |
---|---|---|---|
plasmacytoid dendritic cell | 10 studies | 26% ± 7% | |
macrophage | 7 studies | 20% ± 7% | |
non-classical monocyte | 6 studies | 28% ± 10% | |
myeloid cell | 6 studies | 22% ± 4% | |
conventional dendritic cell | 5 studies | 32% ± 18% | |
dendritic cell | 5 studies | 32% ± 15% | |
microglial cell | 4 studies | 22% ± 5% | |
B cell | 4 studies | 18% ± 3% | |
glutamatergic neuron | 4 studies | 26% ± 8% | |
classical monocyte | 3 studies | 29% ± 6% | |
GABAergic neuron | 3 studies | 23% ± 5% | |
smooth muscle cell | 3 studies | 17% ± 1% | |
goblet cell | 3 studies | 23% ± 2% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 5 studies | 20% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
skin | 100% | 4555.57 | 1806 / 1809 | 99% | 63.91 | 469 / 472 |
bladder | 100% | 15472.57 | 21 / 21 | 98% | 26.74 | 495 / 504 |
prostate | 100% | 9253.96 | 244 / 245 | 99% | 25.04 | 495 / 502 |
lung | 100% | 10906.37 | 578 / 578 | 98% | 21.43 | 1129 / 1155 |
uterus | 100% | 8909.45 | 170 / 170 | 98% | 24.73 | 448 / 459 |
breast | 100% | 4075.70 | 457 / 459 | 97% | 19.73 | 1089 / 1118 |
esophagus | 98% | 3303.54 | 1418 / 1445 | 97% | 19.59 | 178 / 183 |
stomach | 95% | 3947.85 | 341 / 359 | 99% | 26.72 | 284 / 286 |
intestine | 94% | 6343.20 | 907 / 966 | 100% | 29.70 | 526 / 527 |
brain | 93% | 4107.44 | 2455 / 2642 | 100% | 40.05 | 704 / 705 |
kidney | 99% | 4600.19 | 88 / 89 | 93% | 20.94 | 840 / 901 |
thymus | 100% | 4235.49 | 650 / 653 | 92% | 16.40 | 557 / 605 |
ovary | 91% | 3595.88 | 163 / 180 | 66% | 7.02 | 285 / 430 |
adrenal gland | 72% | 1485.41 | 187 / 258 | 75% | 20.53 | 173 / 230 |
pancreas | 47% | 1001.30 | 153 / 328 | 99% | 30.69 | 176 / 178 |
lymph node | 0% | 0 | 0 / 0 | 100% | 75.12 | 29 / 29 |
spleen | 100% | 16459.66 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.65 | 1 / 1 |
blood vessel | 100% | 9896.29 | 1334 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 100% | 18215.70 | 928 / 929 | 0% | 0 | 0 / 0 |
adipose | 99% | 5201.20 | 1197 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 62.27 | 79 / 80 |
tonsil | 0% | 0 | 0 / 0 | 96% | 23.02 | 43 / 45 |
heart | 72% | 1575.99 | 623 / 861 | 0% | 0 | 0 / 0 |
liver | 19% | 416.21 | 43 / 226 | 48% | 7.06 | 196 / 406 |
muscle | 17% | 308.18 | 133 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0019417 | Biological process | sulfur oxidation |
GO_0030042 | Biological process | actin filament depolymerization |
GO_0007165 | Biological process | signal transduction |
GO_0007010 | Biological process | cytoskeleton organization |
GO_1903305 | Biological process | regulation of regulated secretory pathway |
GO_0051017 | Biological process | actin filament bundle assembly |
GO_0001933 | Biological process | negative regulation of protein phosphorylation |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_0030496 | Cellular component | midbody |
GO_0005886 | Cellular component | plasma membrane |
GO_1990026 | Cellular component | hippocampal mossy fiber expansion |
GO_0005884 | Cellular component | actin filament |
GO_0045171 | Cellular component | intercellular bridge |
GO_0005882 | Cellular component | intermediate filament |
GO_0015629 | Cellular component | actin cytoskeleton |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0010008 | Cellular component | endosome membrane |
GO_0016709 | Molecular function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
GO_0071949 | Molecular function | FAD binding |
GO_0106294 | Molecular function | NADPH oxidase H202-forming activity |
GO_0019901 | Molecular function | protein kinase binding |
GO_0051015 | Molecular function | actin filament binding |
GO_0031267 | Molecular function | small GTPase binding |
GO_0004497 | Molecular function | monooxygenase activity |
GO_0016174 | Molecular function | NAD(P)H oxidase H2O2-forming activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0005515 | Molecular function | protein binding |
GO_0003779 | Molecular function | actin binding |
GO_0017124 | Molecular function | SH3 domain binding |
Gene name | MICAL1 |
Protein name | Microtubule associated monooxygenase, calponin and LIM domain containing 1 [F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (EC 1.6.3.1) (Molecule interacting with CasL protein 1) (MICAL-1) (NEDD9-interacting protein with calponin homology and LIM domains) Molecule interacting with CasL protein 1 (EC 1.14.13.225) (EC 1.6.3.1) |
Synonyms | MICAL NICAL |
Description | FUNCTION: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization . In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) . Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export . . |
Accessions | ENST00000358807.8 [Q8TDZ2-1] ENST00000358577.7 [Q8TDZ2-2] ENST00000630715.2 [Q8TDZ2-4] ENST00000431946.1 ENST00000433205.1 Q8TDZ2 H0Y6Z4 A0A1S5UZH2 Q5TED7 |