TMBIM6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	47 studies	47% ± 15%	Explore
endothelial cell	45 studies	57% ± 18%	Explore
macrophage	43 studies	63% ± 19%	Explore
fibroblast	43 studies	54% ± 20%	Explore
natural killer cell	41 studies	55% ± 14%	Explore
T cell	40 studies	48% ± 18%	Explore
CD8-positive, alpha-beta T cell	36 studies	55% ± 16%	Explore
pericyte	35 studies	53% ± 19%	Explore
CD4-positive, alpha-beta T cell	31 studies	55% ± 16%	Explore
smooth muscle cell	29 studies	46% ± 14%	Explore
conventional dendritic cell	29 studies	65% ± 14%	Explore
classical monocyte	28 studies	60% ± 17%	Explore
plasmacytoid dendritic cell	26 studies	66% ± 19%	Explore
regulatory T cell	26 studies	60% ± 14%	Explore
epithelial cell	26 studies	64% ± 23%	Explore
dendritic cell	25 studies	57% ± 21%	Explore
plasma cell	25 studies	70% ± 17%	Explore
endothelial cell of lymphatic vessel	25 studies	61% ± 20%	Explore
non-classical monocyte	25 studies	66% ± 14%	Explore
monocyte	23 studies	54% ± 18%	Explore
mature NK T cell	22 studies	51% ± 15%	Explore
basal cell	22 studies	65% ± 19%	Explore
connective tissue cell	21 studies	54% ± 14%	Explore
mast cell	20 studies	46% ± 17%	Explore
ciliated cell	20 studies	77% ± 20%	Explore
gamma-delta T cell	20 studies	54% ± 18%	Explore
memory B cell	20 studies	52% ± 11%	Explore
naive B cell	19 studies	46% ± 12%	Explore
astrocyte	19 studies	41% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	48% ± 13%	Explore
mucosal invariant T cell	16 studies	51% ± 17%	Explore
capillary endothelial cell	16 studies	52% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	48% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	51% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	59% ± 12%	Explore
myofibroblast cell	15 studies	51% ± 16%	Explore
myeloid cell	15 studies	62% ± 22%	Explore
oligodendrocyte	14 studies	39% ± 13%	Explore
microglial cell	14 studies	38% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	58% ± 14%	Explore
endothelial cell of artery	13 studies	58% ± 18%	Explore
vein endothelial cell	13 studies	53% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	54% ± 18%	Explore
plasmablast	12 studies	73% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	55% ± 15%	Explore
secretory cell	12 studies	75% ± 8%	Explore
oligodendrocyte precursor cell	12 studies	38% ± 16%	Explore
endothelial cell of vascular tree	12 studies	56% ± 11%	Explore
neutrophil	11 studies	38% ± 10%	Explore
mesothelial cell	11 studies	53% ± 15%	Explore
type I pneumocyte	10 studies	68% ± 22%	Explore
type II pneumocyte	10 studies	69% ± 25%	Explore
club cell	10 studies	64% ± 26%	Explore
platelet	10 studies	37% ± 10%	Explore
leukocyte	10 studies	54% ± 11%	Explore
progenitor cell	10 studies	63% ± 16%	Explore
goblet cell	10 studies	63% ± 17%	Explore
glutamatergic neuron	10 studies	39% ± 19%	Explore
GABAergic neuron	9 studies	35% ± 15%	Explore
abnormal cell	9 studies	70% ± 16%	Explore
neuron	9 studies	44% ± 17%	Explore
IgG plasma cell	9 studies	49% ± 20%	Explore
alveolar macrophage	8 studies	62% ± 25%	Explore
innate lymphoid cell	8 studies	54% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	62% ± 19%	Explore
enterocyte	8 studies	63% ± 25%	Explore
IgA plasma cell	8 studies	50% ± 23%	Explore
T follicular helper cell	8 studies	51% ± 16%	Explore
ionocyte	7 studies	71% ± 8%	Explore
respiratory goblet cell	7 studies	65% ± 24%	Explore
mononuclear phagocyte	7 studies	56% ± 23%	Explore
epithelial cell of proximal tubule	7 studies	68% ± 12%	Explore
hematopoietic stem cell	7 studies	53% ± 12%	Explore
erythrocyte	7 studies	44% ± 19%	Explore
hematopoietic precursor cell	6 studies	59% ± 21%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	68% ± 18%	Explore
kidney loop of Henle epithelial cell	6 studies	61% ± 23%	Explore
renal alpha-intercalated cell	6 studies	77% ± 9%	Explore
megakaryocyte	6 studies	58% ± 23%	Explore
retinal rod cell	6 studies	31% ± 16%	Explore
precursor B cell	6 studies	55% ± 13%	Explore
adipocyte	6 studies	24% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	64% ± 16%	Explore
hepatocyte	6 studies	60% ± 29%	Explore
CD4-positive helper T cell	5 studies	47% ± 16%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	51% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	55% ± 15%	Explore
exhausted T cell	5 studies	69% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	81% ± 6%	Explore
intestinal crypt stem cell	5 studies	47% ± 22%	Explore
transit amplifying cell	5 studies	59% ± 24%	Explore
amacrine cell	5 studies	41% ± 16%	Explore
retinal cone cell	5 studies	48% ± 25%	Explore
erythroblast	5 studies	52% ± 24%	Explore
pro-B cell	5 studies	47% ± 17%	Explore
brush cell	5 studies	39% ± 23%	Explore
neuroendocrine cell	5 studies	69% ± 19%	Explore
T-helper 17 cell	5 studies	61% ± 19%	Explore
group 3 innate lymphoid cell	5 studies	73% ± 9%	Explore
immature B cell	5 studies	52% ± 7%	Explore
mucus secreting cell	5 studies	57% ± 23%	Explore
glial cell	5 studies	40% ± 21%	Explore
Mueller cell	5 studies	51% ± 24%	Explore
double negative thymocyte	5 studies	68% ± 14%	Explore
intermediate monocyte	5 studies	70% ± 16%	Explore
granulocyte	5 studies	50% ± 10%	Explore
deuterosomal cell	4 studies	75% ± 12%	Explore
duct epithelial cell	4 studies	81% ± 7%	Explore
squamous epithelial cell	4 studies	67% ± 12%	Explore
pancreatic A cell	4 studies	90% ± 9%	Explore
type B pancreatic cell	4 studies	78% ± 17%	Explore
glomerular endothelial cell	4 studies	59% ± 12%	Explore
podocyte	4 studies	74% ± 7%	Explore
enteroendocrine cell	4 studies	66% ± 10%	Explore
OFF-bipolar cell	4 studies	37% ± 12%	Explore
ON-bipolar cell	4 studies	39% ± 13%	Explore
retinal ganglion cell	4 studies	68% ± 22%	Explore
lymphocyte	4 studies	56% ± 22%	Explore
retina horizontal cell	4 studies	50% ± 14%	Explore
retinal pigment epithelial cell	4 studies	54% ± 25%	Explore
adventitial cell	4 studies	68% ± 14%	Explore
inflammatory macrophage	4 studies	57% ± 7%	Explore
acinar cell	4 studies	62% ± 23%	Explore
endothelial cell of sinusoid	4 studies	40% ± 6%	Explore
muscle cell	4 studies	36% ± 20%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	87% ± 5%	Explore
luminal cell of prostate epithelium	4 studies	70% ± 16%	Explore
keratinocyte	4 studies	39% ± 14%	Explore
interneuron	4 studies	43% ± 16%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	65% ± 20%	Explore
hillock cell	3 studies	59% ± 18%	Explore
precursor cell	3 studies	66% ± 9%	Explore
pancreatic D cell	3 studies	89% ± 12%	Explore
monocyte-derived dendritic cell	3 studies	64% ± 15%	Explore
renal beta-intercalated cell	3 studies	81% ± 14%	Explore
kidney connecting tubule epithelial cell	3 studies	88% ± 5%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	57% ± 19%	Explore
neural crest cell	3 studies	42% ± 7%	Explore
retinal bipolar neuron	3 studies	55% ± 10%	Explore
renal principal cell	3 studies	88% ± 5%	Explore
thymocyte	3 studies	39% ± 17%	Explore
extravillous trophoblast	3 studies	92% ± 2%	Explore
placental villous trophoblast	3 studies	90% ± 4%	Explore
Schwann cell	3 studies	55% ± 20%	Explore
serous secreting cell	3 studies	64% ± 1%	Explore
tissue-resident macrophage	3 studies	64% ± 22%	Explore
intraepithelial lymphocyte	3 studies	62% ± 17%	Explore
rod bipolar cell	3 studies	41% ± 14%	Explore
germinal center B cell	3 studies	43% ± 7%	Explore
myoepithelial cell	3 studies	62% ± 6%	Explore
IgM plasma cell	3 studies	59% ± 7%	Explore
pancreatic ductal cell	3 studies	93% ± 5%	Explore
ependymal cell	3 studies	39% ± 19%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	75% ± 11%	Explore
melanocyte	3 studies	44% ± 13%	Explore
granule cell	3 studies	25% ± 6%	Explore
T-helper 1 cell	3 studies	75% ± 10%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	60% ± 16%	Explore
double-positive, alpha-beta thymocyte	3 studies	75% ± 10%	Explore
progenitor cell of mammary luminal epithelium	3 studies	72% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	55% ± 13%	Explore
lung	19 studies	64% ± 16%	Explore
brain	18 studies	42% ± 15%	Explore
intestine	11 studies	56% ± 15%	Explore
eye	10 studies	41% ± 18%	Explore
kidney	9 studies	64% ± 10%	Explore
liver	7 studies	57% ± 15%	Explore
lymph node	6 studies	56% ± 22%	Explore
bone marrow	6 studies	46% ± 15%	Explore
pancreas	5 studies	74% ± 24%	Explore
uterus	5 studies	67% ± 16%	Explore
prostate	5 studies	56% ± 14%	Explore
placenta	4 studies	72% ± 28%	Explore
heart	4 studies	28% ± 8%	Explore
adipose	4 studies	38% ± 10%	Explore
esophagus	4 studies	49% ± 26%	Explore
breast	4 studies	69% ± 6%	Explore
adrenal gland	3 studies	57% ± 7%	Explore
skin	3 studies	44% ± 8%	Explore
thymus	3 studies	61% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	33152.70	459 / 459	100%	720.04	1118 / 1118
esophagus	100%	28772.04	1445 / 1445	100%	506.30	183 / 183
intestine	100%	32469.88	966 / 966	100%	542.52	527 / 527
kidney	100%	40483.46	89 / 89	100%	700.42	901 / 901
liver	100%	58775.12	226 / 226	100%	606.51	406 / 406
lung	100%	37006.97	578 / 578	100%	529.60	1155 / 1155
ovary	100%	25174.68	180 / 180	100%	524.63	430 / 430
pancreas	100%	21974.14	328 / 328	100%	470.60	178 / 178
prostate	100%	27644.25	245 / 245	100%	663.83	502 / 502
stomach	100%	35782.87	359 / 359	100%	528.60	286 / 286
uterus	100%	24812.47	170 / 170	100%	437.12	459 / 459
brain	100%	25769.34	2641 / 2642	100%	570.79	704 / 705
thymus	100%	41034.68	653 / 653	100%	643.11	603 / 605
bladder	100%	29765.38	21 / 21	100%	508.13	502 / 504
skin	100%	30485.60	1809 / 1809	100%	352.55	470 / 472
adrenal gland	100%	45734.74	258 / 258	99%	372.81	227 / 230
adipose	100%	32266.33	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	317.40	29 / 29
spleen	100%	25793.00	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	403.90	45 / 45
ureter	0%	0	0 / 0	100%	197.03	1 / 1
blood vessel	100%	25659.27	1334 / 1335	0%	0	0 / 0
muscle	100%	16499.87	801 / 803	0%	0	0 / 0
peripheral blood	99%	33184.77	919 / 929	0%	0	0 / 0
heart	98%	15191.84	846 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	98%	248.65	78 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0033119	Biological process	negative regulation of RNA splicing
GO_0034620	Biological process	cellular response to unfolded protein
GO_1902236	Biological process	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO_0036483	Biological process	neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0002638	Biological process	negative regulation of immunoglobulin production
GO_0043066	Biological process	negative regulation of apoptotic process
GO_2001234	Biological process	negative regulation of apoptotic signaling pathway
GO_0060702	Biological process	negative regulation of endoribonuclease activity
GO_0006914	Biological process	autophagy
GO_0032091	Biological process	negative regulation of protein binding
GO_1903298	Biological process	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
GO_1902065	Biological process	response to L-glutamate
GO_0032469	Biological process	endoplasmic reticulum calcium ion homeostasis
GO_0010523	Biological process	negative regulation of calcium ion transport into cytosol
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0031966	Cellular component	mitochondrial membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0019899	Molecular function	enzyme binding
GO_0060698	Molecular function	endoribonuclease inhibitor activity
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TMBIM6
Protein name	Bax inhibitor 1 (Testis-enhanced gene transcript protein) (Transmembrane BAX inhibitor motif-containing protein 6) Transmembrane BAX inhibitor motif containing 6 Bax inhibitor 1 (BI-1) (Testis-enhanced gene transcript protein) (Transmembrane BAX inhibitor motif-containing protein 6)
Synonyms	TEGT BI1
Description	FUNCTION: Suppressor of apoptosis . Modulates unfolded protein response signaling . Modulates ER calcium homeostasis by acting as a calcium-leak channel . Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity). .
Accessions	F8W1V3 ENST00000267115.10 [P55061-1] ENST00000550951.5 F8VQW0 ENST00000551154.5 ENST00000548809.5 F8VQQ5 ENST00000548894.5 ENST00000552635.5 A0A0G2JKZ4 ENST00000549445.5 F8VVJ4 ENST00000549966.5 F8W201 ENST00000552370.5 [P55061-1] ENST00000549385.5 [P55061-1] ENST00000548201.5 ENST00000550445.5 ENST00000546796.5 ENST00000423828.5 [P55061-2] ENST00000395006.8 [P55061-1] F8W086 ENST00000549130.5 ENST00000547832.5 F8VPI1 ENST00000548713.5 ENST00000547187.5 F8W1G3 ENST00000546914.5 ENST00000552699.5 [P55061-2] P55061 F8VSI7 F8VR05 F8VX73 F8VY06 ENST00000547798.1

TMBIM6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review