TIMP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	48 studies	69% ± 25%	Explore
macrophage	42 studies	49% ± 20%	Explore
endothelial cell	42 studies	56% ± 23%	Explore
pericyte	37 studies	63% ± 23%	Explore
smooth muscle cell	30 studies	55% ± 23%	Explore
conventional dendritic cell	29 studies	62% ± 17%	Explore
monocyte	28 studies	60% ± 22%	Explore
classical monocyte	27 studies	76% ± 11%	Explore
endothelial cell of lymphatic vessel	25 studies	72% ± 21%	Explore
dendritic cell	24 studies	52% ± 20%	Explore
non-classical monocyte	24 studies	89% ± 9%	Explore
mast cell	23 studies	59% ± 17%	Explore
connective tissue cell	21 studies	70% ± 21%	Explore
CD4-positive, alpha-beta T cell	20 studies	27% ± 10%	Explore
natural killer cell	19 studies	21% ± 6%	Explore
basal cell	19 studies	49% ± 17%	Explore
epithelial cell	15 studies	46% ± 20%	Explore
regulatory T cell	15 studies	21% ± 7%	Explore
myofibroblast cell	14 studies	70% ± 18%	Explore
myeloid cell	14 studies	45% ± 22%	Explore
T cell	13 studies	28% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	22% ± 5%	Explore
mesothelial cell	13 studies	80% ± 12%	Explore
plasma cell	12 studies	37% ± 16%	Explore
endothelial cell of artery	12 studies	49% ± 15%	Explore
capillary endothelial cell	12 studies	50% ± 18%	Explore
vein endothelial cell	12 studies	66% ± 18%	Explore
endothelial cell of vascular tree	12 studies	56% ± 12%	Explore
platelet	10 studies	71% ± 11%	Explore
neutrophil	10 studies	55% ± 18%	Explore
secretory cell	10 studies	60% ± 14%	Explore
gamma-delta T cell	10 studies	24% ± 6%	Explore
innate lymphoid cell	9 studies	38% ± 23%	Explore
CD8-positive, alpha-beta T cell	9 studies	28% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	22% ± 4%	Explore
ciliated cell	9 studies	39% ± 18%	Explore
mature NK T cell	9 studies	24% ± 8%	Explore
leukocyte	8 studies	39% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	23% ± 8%	Explore
abnormal cell	8 studies	51% ± 17%	Explore
mucosal invariant T cell	8 studies	22% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	33% ± 14%	Explore
mononuclear phagocyte	7 studies	57% ± 21%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	20% ± 3%	Explore
alveolar macrophage	6 studies	36% ± 9%	Explore
club cell	6 studies	46% ± 11%	Explore
astrocyte	6 studies	33% ± 17%	Explore
megakaryocyte	6 studies	82% ± 14%	Explore
intermediate monocyte	6 studies	79% ± 14%	Explore
B cell	5 studies	24% ± 9%	Explore
respiratory goblet cell	5 studies	45% ± 23%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	22% ± 7%	Explore
monocyte-derived dendritic cell	5 studies	71% ± 18%	Explore
endothelial cell of sinusoid	5 studies	58% ± 27%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	22% ± 3%	Explore
neuroendocrine cell	5 studies	67% ± 21%	Explore
adventitial cell	5 studies	75% ± 30%	Explore
inflammatory macrophage	5 studies	51% ± 13%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	43% ± 17%	Explore
adipocyte	5 studies	29% ± 14%	Explore
granulocyte	5 studies	50% ± 20%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	41% ± 12%	Explore
hematopoietic stem cell	5 studies	37% ± 22%	Explore
CD4-positive helper T cell	4 studies	19% ± 4%	Explore
hematopoietic precursor cell	4 studies	37% ± 10%	Explore
plasmablast	4 studies	29% ± 10%	Explore
pancreatic A cell	4 studies	78% ± 11%	Explore
type B pancreatic cell	4 studies	74% ± 10%	Explore
oligodendrocyte precursor cell	4 studies	24% ± 7%	Explore
glomerular endothelial cell	4 studies	47% ± 7%	Explore
progenitor cell	4 studies	33% ± 17%	Explore
kidney loop of Henle epithelial cell	4 studies	28% ± 12%	Explore
lymphocyte	4 studies	36% ± 21%	Explore
mucus secreting cell	4 studies	76% ± 22%	Explore
glial cell	4 studies	38% ± 15%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	43% ± 7%	Explore
luminal cell of prostate epithelium	4 studies	56% ± 18%	Explore
erythrocyte	4 studies	26% ± 6%	Explore
enteroendocrine cell	4 studies	39% ± 14%	Explore
group 3 innate lymphoid cell	4 studies	39% ± 12%	Explore
Langerhans cell	3 studies	60% ± 11%	Explore
duct epithelial cell	3 studies	66% ± 15%	Explore
ionocyte	3 studies	23% ± 5%	Explore
pancreatic D cell	3 studies	86% ± 8%	Explore
hepatic stellate cell	3 studies	20% ± 5%	Explore
podocyte	3 studies	62% ± 5%	Explore
epithelial cell of proximal tubule	3 studies	30% ± 17%	Explore
neural crest cell	3 studies	24% ± 10%	Explore
extravillous trophoblast	3 studies	44% ± 17%	Explore
Schwann cell	3 studies	66% ± 4%	Explore
microglial cell	3 studies	28% ± 15%	Explore
serous secreting cell	3 studies	42% ± 0%	Explore
tissue-resident macrophage	3 studies	41% ± 13%	Explore
intraepithelial lymphocyte	3 studies	17% ± 1%	Explore
Mueller cell	3 studies	32% ± 6%	Explore
IgA plasma cell	3 studies	45% ± 12%	Explore
IgG plasma cell	3 studies	33% ± 13%	Explore
myoepithelial cell	3 studies	55% ± 23%	Explore
neuron	3 studies	32% ± 10%	Explore
pancreatic ductal cell	3 studies	59% ± 3%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	61% ± 24%	Explore
brush cell	3 studies	30% ± 17%	Explore
hepatocyte	3 studies	23% ± 7%	Explore
T-helper 17 cell	3 studies	21% ± 1%	Explore
T-helper 1 cell	3 studies	33% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	24% ± 7%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	32% ± 10%	Explore
double negative thymocyte	3 studies	20% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	46% ± 17%	Explore
peripheral blood	18 studies	35% ± 9%	Explore
intestine	9 studies	43% ± 17%	Explore
kidney	7 studies	32% ± 14%	Explore
liver	7 studies	30% ± 8%	Explore
uterus	6 studies	56% ± 15%	Explore
prostate	5 studies	48% ± 18%	Explore
pancreas	4 studies	66% ± 17%	Explore
brain	4 studies	28% ± 6%	Explore
placenta	4 studies	36% ± 24%	Explore
heart	4 studies	27% ± 11%	Explore
adipose	4 studies	35% ± 11%	Explore
skin	4 studies	36% ± 17%	Explore
breast	4 studies	41% ± 6%	Explore
bone marrow	3 studies	34% ± 18%	Explore
ovary	3 studies	53% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	27557.79	180 / 180	98%	1096.08	423 / 430
lung	100%	42593.16	577 / 578	96%	985.86	1110 / 1155
adrenal gland	100%	29600.46	257 / 258	96%	1097.38	221 / 230
prostate	100%	26765.17	244 / 245	86%	460.33	434 / 502
bladder	95%	35122.48	20 / 21	90%	828.28	455 / 504
breast	88%	8851.75	404 / 459	97%	801.73	1081 / 1118
uterus	100%	12806.04	170 / 170	80%	768.25	369 / 459
thymus	92%	12443.78	603 / 653	84%	1447.79	511 / 605
intestine	69%	6530.78	669 / 966	97%	843.43	511 / 527
kidney	75%	12132.62	67 / 89	89%	839.61	802 / 901
skin	55%	24683.04	996 / 1809	99%	1655.48	465 / 472
esophagus	63%	6343.40	908 / 1445	90%	609.95	164 / 183
stomach	47%	5279.26	170 / 359	98%	1003.97	280 / 286
pancreas	26%	2260.71	86 / 328	96%	1889.11	170 / 178
liver	50%	8242.04	112 / 226	67%	754.01	273 / 406
ureter	0%	0	0 / 0	100%	317.22	1 / 1
blood vessel	100%	48859.64	1330 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	1600.14	27 / 29
adipose	92%	20850.77	1107 / 1204	0%	0	0 / 0
spleen	90%	7883.58	217 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	85%	354.87	68 / 80
peripheral blood	83%	15903.42	769 / 929	0%	0	0 / 0
heart	77%	16580.50	661 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	76%	265.98	34 / 45
brain	7%	622.85	192 / 2642	37%	404.28	258 / 705
muscle	5%	344.42	41 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043434	Biological process	response to peptide hormone
GO_0010951	Biological process	negative regulation of endopeptidase activity
GO_0002248	Biological process	connective tissue replacement involved in inflammatory response wound healing
GO_0034097	Biological process	response to cytokine
GO_2001044	Biological process	regulation of integrin-mediated signaling pathway
GO_0007165	Biological process	signal transduction
GO_1901164	Biological process	negative regulation of trophoblast cell migration
GO_0043086	Biological process	negative regulation of catalytic activity
GO_0009725	Biological process	response to hormone
GO_0051045	Biological process	negative regulation of membrane protein ectodomain proteolysis
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_1905049	Biological process	negative regulation of metallopeptidase activity
GO_0051216	Biological process	cartilage development
GO_0071492	Biological process	cellular response to UV-A
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0070062	Cellular component	extracellular exosome
GO_0031012	Cellular component	extracellular matrix
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0031093	Cellular component	platelet alpha granule lumen
GO_0005604	Cellular component	basement membrane
GO_0030414	Molecular function	peptidase inhibitor activity
GO_0008191	Molecular function	metalloendopeptidase inhibitor activity
GO_0008083	Molecular function	growth factor activity
GO_0002020	Molecular function	protease binding
GO_0008270	Molecular function	zinc ion binding
GO_0005515	Molecular function	protein binding
GO_0005125	Molecular function	cytokine activity

IV. Literature review

[source]

Gene name	TIMP1
Protein name	TIMP metallopeptidase inhibitor 1 Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1) Metalloproteinase inhibitor 1 (Tissue inhibitor of metalloproteinases 1)
Synonyms	TIMP CLGI hCG_29141
Description	FUNCTION: Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. .
Accessions	Q6FGX5 ENST00000456754.6 H0Y789 Q5H9B5 P01033 ENST00000377017.5 ENST00000445623.1 ENST00000441738.1 Q5H9A7 Q58P21 ENST00000218388.9 Q5H9B4

TIMP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review