Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| B cell | 4 studies | 20% ± 5% | |
| GABAergic neuron | 4 studies | 21% ± 3% | |
| glutamatergic neuron | 4 studies | 29% ± 8% | |
| germinal center B cell | 3 studies | 27% ± 2% | |
| neuron | 3 studies | 24% ± 4% | |
| astrocyte | 3 studies | 21% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 973.16 | 2642 / 2642 | 100% | 11.23 | 705 / 705 |
| ovary | 100% | 1726.24 | 180 / 180 | 100% | 7.74 | 430 / 430 |
| prostate | 100% | 1352.30 | 245 / 245 | 100% | 7.80 | 501 / 502 |
| thymus | 100% | 1171.96 | 653 / 653 | 100% | 8.82 | 603 / 605 |
| stomach | 100% | 786.85 | 359 / 359 | 100% | 6.85 | 285 / 286 |
| breast | 100% | 1109.75 | 459 / 459 | 99% | 7.01 | 1110 / 1118 |
| intestine | 100% | 1215.11 | 966 / 966 | 99% | 7.13 | 523 / 527 |
| skin | 100% | 914.41 | 1808 / 1809 | 99% | 6.99 | 466 / 472 |
| kidney | 100% | 2003.79 | 89 / 89 | 98% | 8.15 | 887 / 901 |
| lung | 100% | 929.31 | 578 / 578 | 98% | 5.07 | 1137 / 1155 |
| bladder | 100% | 1241.90 | 21 / 21 | 98% | 6.65 | 493 / 504 |
| liver | 100% | 853.29 | 226 / 226 | 98% | 6.39 | 397 / 406 |
| uterus | 100% | 1703.59 | 170 / 170 | 97% | 6.25 | 447 / 459 |
| pancreas | 99% | 464.58 | 324 / 328 | 97% | 5.21 | 173 / 178 |
| esophagus | 100% | 957.58 | 1445 / 1445 | 96% | 4.50 | 175 / 183 |
| adrenal gland | 100% | 1066.79 | 257 / 258 | 90% | 4.33 | 207 / 230 |
| blood vessel | 100% | 1035.90 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 19.88 | 29 / 29 |
| spleen | 100% | 1207.74 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.24 | 1 / 1 |
| adipose | 100% | 1031.73 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| heart | 99% | 573.06 | 851 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 97% | 788.63 | 905 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 5.84 | 43 / 45 |
| muscle | 93% | 338.93 | 749 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 78% | 2.77 | 62 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0032355 | Biological process | response to estradiol |
| GO_0034614 | Biological process | cellular response to reactive oxygen species |
| GO_0045007 | Biological process | depurination |
| GO_0009314 | Biological process | response to radiation |
| GO_0006289 | Biological process | nucleotide-excision repair |
| GO_0006285 | Biological process | base-excision repair, AP site formation |
| GO_0006974 | Biological process | DNA damage response |
| GO_0071276 | Biological process | cellular response to cadmium ion |
| GO_0045471 | Biological process | response to ethanol |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0045008 | Biological process | depyrimidination |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0051593 | Biological process | response to folic acid |
| GO_0009416 | Biological process | response to light stimulus |
| GO_1901291 | Biological process | negative regulation of double-strand break repair via single-strand annealing |
| GO_0009410 | Biological process | response to xenobiotic stimulus |
| GO_0006284 | Biological process | base-excision repair |
| GO_0006979 | Biological process | response to oxidative stress |
| GO_0044029 | Biological process | positive regulation of gene expression via chromosomal CpG island demethylation |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0016607 | Cellular component | nuclear speck |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0016363 | Cellular component | nuclear matrix |
| GO_0005829 | Cellular component | cytosol |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005634 | Cellular component | nucleus |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0034039 | Molecular function | 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity |
| GO_0140078 | Molecular function | class I DNA-(apurinic or apyrimidinic site) endonuclease activity |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0004519 | Molecular function | endonuclease activity |
| GO_0008534 | Molecular function | oxidized purine nucleobase lesion DNA N-glycosylase activity |
| GO_0008017 | Molecular function | microtubule binding |
| GO_0032357 | Molecular function | oxidized purine DNA binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0003684 | Molecular function | damaged DNA binding |
| Gene name | OGG1 |
| Protein name | 8-oxoguanine DNA glycosylase, isoform CRA_g (OGG1 type 1g) OGG1 type 1e DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (AP lyase) (EC 4.2.99.18)] OGG1 type 1d (OGG1 type 1h) 8-oxoguanine DNA glycosylase, isoform CRA_i (OGG1 type 1f) 8-oxoguanine DNA glycosylase, isoform CRA_e (N-glycosylase/DNA lyase) 8-oxoguanine DNA glycosylase |
| Synonyms | 1e 1h 1f type 1g OGH1 hCG_20369 1d MUTM MMH |
| Description | FUNCTION: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. FUNCTION: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. . FUNCTION: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. . FUNCTION: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. . FUNCTION: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. . FUNCTION: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. . FUNCTION: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. . |
| Accessions | Q9HCR7 ENST00000352937.6 ENST00000425665.1 H7C1V7 H7BZM3 A0A9L9PXU1 ENST00000429146.5 H7C0A1 ENST00000344629.12 [O15527-1] ENST00000302036.12 [O15527-4] E5KPN1 ENST00000339511.9 [O15527-2] ENST00000707074.1 E5KPM6 Q9GZT7 F8WCZ9 E5KPM7 E5KPM5 ENST00000383826.9 [O15527-6] ENST00000426518.5 ENST00000416333.1 ENST00000449570.6 [O15527-8] Q9HCR6 E5KPN0 E5KPM9 ENST00000302008.12 [O15527-7] ENST00000302003.11 [O15527-3] ENST00000441094.5 H7BXZ1 H7C1D7 O15527 Q9HCR8 E5KPM8 ENST00000352937.6 [O15527-5] |
