| Name | oxidized purine nucleobase lesion DNA N-glycosylase activity |
| ID | GO_0008534 |
| collection_id | Molecular function |
| Alternative ID | GO:0003907 |
| Exact synonym | oxidized purine base lesion DNA N-glycosylase activity |
| Description | Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. |
| Related synonym | 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity, 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity, DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing], DNA-formamidopyrimidine glycosylase activity, Fapy-DNA glycosylase activity, Fpg protein, deoxyribonucleate glycosidase activity, formamidopyrimidine-DNA glycosylase activity, purine-specific oxidized base lesion DNA N-glycosylase activity |
| Comment | Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'. |
| External URL | |
| Genes |