NTHL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006289Biological processnucleotide-excision repair
GO_0006285Biological processbase-excision repair, AP site formation
GO_0045008Biological processdepyrimidination
GO_0005654Cellular componentnucleoplasm
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0003906Molecular functionDNA-(apurinic or apyrimidinic site) endonuclease activity
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0004519Molecular functionendonuclease activity
GO_0140078Molecular functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO_0008534Molecular functionoxidized purine nucleobase lesion DNA N-glycosylase activity
GO_0019104Molecular functionDNA N-glycosylase activity
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding
GO_0051539Molecular function4 iron, 4 sulfur cluster binding
GO_0000703Molecular functionoxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameNTHL1
Protein nameNth like DNA glycosylase 1
Endonuclease III-like protein 1 (hNTH1) (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase)
DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18)
Endonuclease III-like protein 1 (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase)
SynonymshCG_1989994
NTH1
OCTS3
DescriptionFUNCTION: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage . The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption. .

FUNCTION: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. .

AccessionsENST00000651570.2 [P78549-2]
ENST00000561841.1
A0A494BZZ6
E5KTI5
P78549
ENST00000651583.1
ENST00000651522.1
ENST00000566380.5
H3BPD5
A0A494C106
ENST00000219066.5 [P78549-1]
H3BUV2
ENST00000568513.5
H3BRL9