oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

I. Literature review

[source]
Nameoxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
IDGO_0000703
collection_id

Molecular function

Alternative ID

GO:0019004

Exact synonym

oxidized pyrimidine base lesion DNA N-glycosylase activity

Description

Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.

Related synonym

endodeoxyribonuclease III, endonuclease III, endonuclease VIII activity, pyrimidine-specific oxidized base lesion DNA N-glycosylase activity

Comment

Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.

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Genes