Name | oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity |
ID | GO_0000703 |
collection_id | Molecular function |
Alternative ID | GO:0019004 |
Exact synonym | oxidized pyrimidine base lesion DNA N-glycosylase activity |
Description | Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site. |
Related synonym | endodeoxyribonuclease III, endonuclease III, endonuclease VIII activity, pyrimidine-specific oxidized base lesion DNA N-glycosylase activity |
Comment | Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'. |
External URL | |
Genes |