SMUG1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SMUG1 at tissue level.

III. Associated gene sets

GO_0006284Biological processbase-excision repair
GO_0045008Biological processdepyrimidination
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0001650Cellular componentfibrillar center
GO_0003677Molecular functionDNA binding
GO_0019104Molecular functionDNA N-glycosylase activity
GO_0017065Molecular functionsingle-strand selective uracil DNA N-glycosylase activity
GO_0005515Molecular functionprotein binding
GO_0000703Molecular functionoxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
GO_0004844Molecular functionuracil DNA N-glycosylase activity

IV. Literature review

[source]
Gene nameSMUG1
Protein nameSingle-strand-selective monofunctional uracil-DNA glycosylase 1 isoform 2
Single-strand-selective monofunctional uracil-DNA glycosylase 1
Single-strand selective monofunctional uracil DNA glycosylase (EC 3.2.2.-)
Single-strand-selective monofunctional uracil-DNA glycosylase 1 isoform 1
Synonyms
DescriptionFUNCTION: Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration. .

AccessionsENST00000506595.5 [Q53HV7-2]
ENST00000505128.5
ENST00000504797.1
A0A0U1RRE6
ENST00000514685.5 [Q53HV7-2]
D6RA25
ENST00000506169.5
A0A024RAZ8
D6RAS0
ENST00000503306.5
Q53HV7
ENST00000243112.9 [Q53HV7-2]
ENST00000401977.6 [Q53HV7-1]
D6RAI1
D6RIA4
ENST00000504338.5
ENST00000635546.1
ENST00000682136.1 [Q53HV7-1]
ENST00000513838.5 [Q53HV7-2]
ENST00000337581.7 [Q53HV7-1]
A0A0S2Z526
ENST00000508394.6 [Q53HV7-1]
D6RI04
D6RA78
H0YA95
D6RD88
ENST00000507904.5
ENST00000514196.5
ENST00000509864.5