API5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043066Biological processnegative regulation of apoptotic process
GO_0044346Biological processfibroblast apoptotic process
GO_2000270Biological processnegative regulation of fibroblast apoptotic process
GO_0016607Cellular componentnuclear speck
GO_0005681Cellular componentspliceosomal complex
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0017134Molecular functionfibroblast growth factor binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameAPI5
Protein nameApoptosis inhibitor 5 (API-5) (Antiapoptosis clone 11 protein) (AAC-11) (Cell migration-inducing gene 8 protein) (Fibroblast growth factor 2-interacting factor) (FIF) (Protein XAGL)
Apoptosis inhibitor 5
SynonymsMIG8
DescriptionFUNCTION: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. .

AccessionsE9PQK6
ENST00000420461.6 [Q9BZZ5-5]
Q9BZZ5
ENST00000531273.6 [Q9BZZ5-4]
ENST00000378852.7 [Q9BZZ5-2]
ENST00000455725.6 [Q9BZZ5-6]
H0YER7
ENST00000534600.5 [Q9BZZ5-1]
ENST00000526394.1
ENST00000534695.5