Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell of proximal tubule | 8 studies | 34% ± 12% | |
| type II pneumocyte | 7 studies | 21% ± 6% | |
| hepatocyte | 6 studies | 69% ± 24% | |
| epithelial cell | 6 studies | 41% ± 13% | |
| kidney loop of Henle epithelial cell | 4 studies | 26% ± 10% | |
| kidney distal convoluted tubule epithelial cell | 4 studies | 35% ± 16% | |
| oligodendrocyte | 4 studies | 21% ± 2% | |
| endothelial cell | 3 studies | 23% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 38755.48 | 226 / 226 | 97% | 312.96 | 395 / 406 |
| kidney | 100% | 14519.61 | 89 / 89 | 95% | 141.31 | 859 / 901 |
| prostate | 87% | 1512.06 | 213 / 245 | 98% | 251.31 | 494 / 502 |
| thymus | 100% | 2066.18 | 652 / 653 | 76% | 77.10 | 457 / 605 |
| breast | 69% | 646.54 | 316 / 459 | 69% | 43.37 | 777 / 1118 |
| lung | 91% | 1194.31 | 527 / 578 | 40% | 25.91 | 461 / 1155 |
| pancreas | 100% | 12215.46 | 328 / 328 | 28% | 14.14 | 49 / 178 |
| muscle | 97% | 1176.98 | 778 / 803 | 0% | 0 | 0 / 0 |
| ovary | 20% | 67.48 | 36 / 180 | 68% | 54.53 | 293 / 430 |
| stomach | 77% | 3327.70 | 277 / 359 | 8% | 3.60 | 24 / 286 |
| spleen | 69% | 241.10 | 167 / 241 | 0% | 0 | 0 / 0 |
| heart | 68% | 246.25 | 586 / 861 | 0% | 0 | 0 / 0 |
| brain | 59% | 227.67 | 1560 / 2642 | 0% | 0.11 | 3 / 705 |
| uterus | 16% | 96.15 | 27 / 170 | 13% | 7.12 | 59 / 459 |
| adipose | 26% | 76.49 | 309 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 15% | 3.78 | 12 / 80 |
| intestine | 4% | 14.40 | 39 / 966 | 9% | 3.98 | 46 / 527 |
| esophagus | 3% | 9.97 | 41 / 1445 | 9% | 3.89 | 16 / 183 |
| skin | 3% | 12.53 | 52 / 1809 | 5% | 1.28 | 22 / 472 |
| adrenal gland | 7% | 17.78 | 18 / 258 | 0% | 0.60 | 1 / 230 |
| peripheral blood | 7% | 24.38 | 68 / 929 | 0% | 0 | 0 / 0 |
| bladder | 0% | 0 | 0 / 21 | 6% | 4.12 | 31 / 504 |
| blood vessel | 1% | 4.25 | 12 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_2000347 | Biological process | positive regulation of hepatocyte proliferation |
| GO_2000611 | Biological process | positive regulation of thyroid hormone generation |
| GO_0010756 | Biological process | positive regulation of plasminogen activation |
| GO_0097066 | Biological process | response to thyroid hormone |
| GO_0030307 | Biological process | positive regulation of cell growth |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0097195 | Biological process | pilomotor reflex |
| GO_0090103 | Biological process | cochlea morphogenesis |
| GO_0050680 | Biological process | negative regulation of epithelial cell proliferation |
| GO_0071805 | Biological process | potassium ion transmembrane transport |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0010719 | Biological process | negative regulation of epithelial to mesenchymal transition |
| GO_0043923 | Biological process | positive regulation by host of viral transcription |
| GO_0006508 | Biological process | proteolysis |
| GO_0034769 | Biological process | basement membrane disassembly |
| GO_0008360 | Biological process | regulation of cell shape |
| GO_0050910 | Biological process | detection of mechanical stimulus involved in sensory perception of sound |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0005911 | Cellular component | cell-cell junction |
| GO_0009986 | Cellular component | cell surface |
| GO_0031965 | Cellular component | nuclear membrane |
| GO_0008233 | Molecular function | peptidase activity |
| GO_0070008 | Molecular function | serine-type exopeptidase activity |
| GO_0008236 | Molecular function | serine-type peptidase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0004252 | Molecular function | serine-type endopeptidase activity |
| Gene name | HPN |
| Protein name | Serine protease hepsin (EC 3.4.21.106) (Transmembrane protease serine 1) [Cleaved into: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain] Hepsin Alternative protein HPN |
| Synonyms | TMPRSS1 |
| Description | FUNCTION: Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL . Plays a role in cell growth and maintenance of cell morphology . Plays a role in the proteolytic processing of ACE2 . Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization . . |
| Accessions | M0QZ63 ENST00000673426.1 L8E9T7 ENST00000597419.1 ENST00000672452.2 M0R244 ENST00000262626.6 P05981 ENST00000600390.1 ENST00000392226.5 |
