CBX4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0016925Biological processprotein sumoylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0031519Cellular componentPcG protein complex
GO_0035102Cellular componentPRC1 complex
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0019899Molecular functionenzyme binding
GO_0019789Molecular functionSUMO transferase activity
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0003682Molecular functionchromatin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0061665Molecular functionSUMO ligase activity
GO_0032183Molecular functionSUMO binding
GO_0051219Molecular functionphosphoprotein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCBX4
Protein nameChromobox-like protein 4 isoform 1
E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2)
Chromobox homolog 4 (Pc class homolog, Drosophila), isoform CRA_a (Chromobox-like protein 4 isoform 2)
Chromobox 4
SynonymshCG_28566
DescriptionFUNCTION: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I . Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 . .; FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development . PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility . Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). .

AccessionsI3L4F1
O00257
ENST00000495122.1
A0A0S2Z5B2
ENST00000269397.9 [O00257-1]
F8WCW6
A0A0S2Z4Q9
ENST00000448310.1