INSL3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of INSL3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of INSL3 at tissue level.

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0007283Biological processspermatogenesis
GO_0007267Biological processcell-cell signaling
GO_0001556Biological processoocyte maturation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0007193Biological processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO_0043950Biological processpositive regulation of cAMP-mediated signaling
GO_0008584Biological processmale gonad development
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0010634Biological processpositive regulation of epithelial cell migration
GO_0090303Biological processpositive regulation of wound healing
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005158Molecular functioninsulin receptor binding
GO_0005179Molecular functionhormone activity
GO_0005102Molecular functionsignaling receptor binding
GO_0001664Molecular functionG protein-coupled receptor binding
GO_0002020Molecular functionprotease binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameINSL3
Protein nameInsulin like 3
Insulin-like 3 (Leydig insulin-like peptide) (Ley-I-L) (Relaxin-like factor) [Cleaved into: Insulin-like 3 B chain; Insulin-like 3 A chain]
SynonymsRLF
RLNL
DescriptionFUNCTION: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

AccessionsP51460
M0QXQ3
ENST00000598577.1
ENST00000317306.8 [P51460-1]
ENST00000379695.5 [P51460-2]