Name | Number of supported studies | Average coverage | |
---|---|---|---|
smooth muscle cell | 25 studies | 36% ± 18% | |
pericyte | 24 studies | 39% ± 20% | |
fibroblast | 19 studies | 38% ± 17% | |
macrophage | 14 studies | 28% ± 11% | |
oligodendrocyte precursor cell | 10 studies | 41% ± 20% | |
endothelial cell | 8 studies | 31% ± 12% | |
adipocyte | 8 studies | 52% ± 10% | |
dendritic cell | 8 studies | 25% ± 10% | |
retinal rod cell | 7 studies | 39% ± 26% | |
epithelial cell | 6 studies | 31% ± 11% | |
myeloid cell | 6 studies | 35% ± 18% | |
astrocyte | 6 studies | 34% ± 17% | |
cardiac muscle cell | 5 studies | 57% ± 16% | |
retinal cone cell | 5 studies | 32% ± 17% | |
myofibroblast cell | 5 studies | 41% ± 17% | |
glutamatergic neuron | 5 studies | 37% ± 16% | |
connective tissue cell | 5 studies | 27% ± 11% | |
monocyte | 5 studies | 26% ± 12% | |
GABAergic neuron | 4 studies | 32% ± 10% | |
muscle cell | 4 studies | 42% ± 27% | |
alveolar macrophage | 4 studies | 51% ± 18% | |
hepatic stellate cell | 3 studies | 53% ± 5% | |
mesothelial cell | 3 studies | 30% ± 9% | |
lymphocyte | 3 studies | 28% ± 4% | |
retinal pigment epithelial cell | 3 studies | 47% ± 19% | |
group 3 innate lymphoid cell | 3 studies | 23% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 99% | 2658.16 | 649 / 653 | 100% | 8.18 | 605 / 605 |
esophagus | 100% | 9312.17 | 1445 / 1445 | 98% | 5.67 | 179 / 183 |
prostate | 98% | 3993.15 | 240 / 245 | 100% | 7.81 | 501 / 502 |
breast | 100% | 3570.29 | 459 / 459 | 97% | 4.74 | 1085 / 1118 |
skin | 100% | 2988.57 | 1807 / 1809 | 96% | 5.07 | 454 / 472 |
uterus | 99% | 3126.61 | 169 / 170 | 97% | 6.42 | 443 / 459 |
lung | 97% | 2328.47 | 562 / 578 | 97% | 5.13 | 1116 / 1155 |
bladder | 100% | 6661.48 | 21 / 21 | 94% | 6.94 | 472 / 504 |
adrenal gland | 94% | 1517.98 | 242 / 258 | 93% | 5.38 | 215 / 230 |
stomach | 95% | 3165.85 | 340 / 359 | 86% | 3.66 | 245 / 286 |
ovary | 100% | 4687.54 | 180 / 180 | 78% | 1.94 | 336 / 430 |
intestine | 93% | 4606.75 | 894 / 966 | 80% | 3.06 | 423 / 527 |
kidney | 62% | 956.70 | 55 / 89 | 93% | 5.75 | 837 / 901 |
pancreas | 30% | 343.66 | 100 / 328 | 98% | 5.53 | 175 / 178 |
adipose | 100% | 4643.25 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 8599.00 | 1335 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 7.52 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.17 | 1 / 1 |
muscle | 100% | 3246.24 | 800 / 803 | 0% | 0 | 0 / 0 |
brain | 2% | 23.43 | 51 / 2642 | 97% | 3.14 | 687 / 705 |
heart | 96% | 3125.91 | 828 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 94% | 3.73 | 75 / 80 |
lymph node | 0% | 0 | 0 / 0 | 79% | 2.08 | 23 / 29 |
liver | 23% | 283.46 | 52 / 226 | 54% | 1.42 | 221 / 406 |
spleen | 73% | 1211.67 | 175 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 19% | 460.94 | 174 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007165 | Biological process | signal transduction |
GO_0051056 | Biological process | regulation of small GTPase mediated signal transduction |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_0007010 | Biological process | cytoskeleton organization |
GO_0010008 | Cellular component | endosome membrane |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0005515 | Molecular function | protein binding |
GO_0005096 | Molecular function | GTPase activator activity |
Gene name | ARHGAP10 |
Protein name | ARHGAP10 (Rho GTPase activating protein 10, isoform CRA_a) ARHGAP10 protein Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (GRAF2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10) Rho GTPase activating protein 10 |
Synonyms | GRAF2 hCG_1811988 |
Description | FUNCTION: GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes . Also converts Cdc42 to an inactive GDP-bound state . Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins . . |
Accessions | Q86T21 H0Y8W5 A0A2X0SFB3 Q3KQX3 ENST00000336498.8 ENST00000507661.1 A1A4S6 |