ARHGAP10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0043066Biological processnegative regulation of apoptotic process
GO_0007010Biological processcytoskeleton organization
GO_0010008Cellular componentendosome membrane
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005515Molecular functionprotein binding
GO_0005096Molecular functionGTPase activator activity

IV. Literature review

[source]
Gene nameARHGAP10
Protein nameARHGAP10 (Rho GTPase activating protein 10, isoform CRA_a)
ARHGAP10 protein
Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (GRAF2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10)
Rho GTPase activating protein 10
SynonymsGRAF2
hCG_1811988
DescriptionFUNCTION: GTPase-activating protein that catalyzes the conversion of active GTP-bound Rho GTPases to their inactive GDP-bound form, thus suppressing various Rho GTPase-mediated cellular processes . Also converts Cdc42 to an inactive GDP-bound state . Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation with MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins . .

AccessionsQ86T21
H0Y8W5
A0A2X0SFB3
Q3KQX3
ENST00000336498.8
ENST00000507661.1
A1A4S6