PLK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0007265Biological processRas protein signal transduction
GO_0007052Biological processmitotic spindle organization
GO_0002862Biological processnegative regulation of inflammatory response to antigenic stimulus
GO_0060292Biological processlong-term synaptic depression
GO_0046599Biological processregulation of centriole replication
GO_0060291Biological processlong-term synaptic potentiation
GO_0016525Biological processnegative regulation of angiogenesis
GO_0090050Biological processpositive regulation of cell migration involved in sprouting angiogenesis
GO_0032486Biological processRap protein signal transduction
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0048167Biological processregulation of synaptic plasticity
GO_0043066Biological processnegative regulation of apoptotic process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0010508Biological processpositive regulation of autophagy
GO_0006977Biological processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO_0071866Biological processnegative regulation of apoptotic process in bone marrow cell
GO_0007613Biological processmemory
GO_0006468Biological processprotein phosphorylation
GO_2000773Biological processnegative regulation of cellular senescence
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0000922Cellular componentspindle pole
GO_0005813Cellular componentcentrosome
GO_0000776Cellular componentkinetochore
GO_0005814Cellular componentcentriole
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0043008Molecular functionATP-dependent protein binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLK2
Protein nameSerine/threonine-protein kinase PLK (EC 2.7.11.21) (Polo-like kinase)
Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 2) (PLK-2) (hPlk2) (Serine/threonine-protein kinase SNK) (hSNK) (Serum-inducible kinase)
SynonymsSNK
DescriptionFUNCTION: Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress. .

AccessionsENST00000617412.1
Q9NYY3
ENST00000274289.8
A0A087WUH9