TWIST2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032868Biological processresponse to insulin
GO_0014070Biological processresponse to organic cyclic compound
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030335Biological processpositive regulation of cell migration
GO_0030154Biological processcell differentiation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0032502Biological processdevelopmental process
GO_0045668Biological processnegative regulation of osteoblast differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTWIST2
Protein nameTwist-related protein 2 (Class A basic helix-loop-helix protein 39) (bHLHa39) (Dermis-expressed protein 1) (Dermo-1)
SynonymsBHLHA39
DERMO1
DescriptionFUNCTION: Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism (By similarity). Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. .

AccessionsENST00000710607.1
ENST00000448943.2
ENST00000710608.1
Q8WVJ9
ENST00000671947.1
ENST00000612363.2
ENST00000673387.1